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Issue Archive

Volume 117, Issue 23
June 9 2011
Blood Cover Image for Volume 117, Issue 23

Table of Contents

Inside Blood

CLINICAL TRIALS
Autografting CLL: the game is over!
Emili Montserrat,John G. Gribben
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THROMBOSIS & HEMOSTASIS
A knockout for knockin
Laurent O. Mosnier
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THROMBOSIS & HEMOSTASIS
FVIII, CD4, and liaisons dangereuses
Margaret V. Ragni
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TRANSPLANTATION
T-cell depletion in GVHD: less is more?
Joseph H. Antin
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Perspectives

International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation
Clinical Trials & Observations
Michele Cavo,S. Vincent Rajkumar,Antonio Palumbo,Philippe Moreau,Robert Orlowski,Joan Bladé,Orhan Sezer,Heinz Ludwig,Meletios A. Dimopoulos,Michel Attal,Pieter Sonneveld,Mario Boccadoro,Kenneth C. Anderson,Paul G. Richardson,William Bensinger,Hans E. Johnsen,Nicolaus Kroeger,Gösta Gahrton,P. Leif Bergsagel,David H. Vesole,Hermann Einsele,Sundar Jagannath,Ruben Niesvizky,Brian G. M. Durie,Jesus San Miguel,Sagar Lonial,on behalf of the International Myeloma Working Group
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Review Articles

Synthetic lethality: exploiting the addiction of cancer to DNA repair
Clinical Trials & Observations
Montaser Shaheen,Christopher Allen,Jac A. Nickoloff,Robert Hromas
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How I Treat

How I treat warfarin-associated coagulopathy in patients with intracerebral hemorrhage
Clinical Trials & Observations
Lawrence Tim Goodnough,Aryeh Shander
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Hematopoiesis and Stem Cells

Ex vivo expansion of human hematopoietic stem and progenitor cells
Ann Dahlberg,Colleen Delaney,Irwin D. Bernstein
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Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters
Brief Report
Tomomasa Yokomizo,Cherry Ee Lin Ng,Motomi Osato,Elaine Dzierzak
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Supplemental data
STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis
Brief Report
Mark H. Kaplan,Nicole L. Glosson,Gretta L. Stritesky,Norman Yeh,John Kinzfogl,Sara L. Rohrabaugh,Ritobrata Goswami,Duy Pham,David E. Levy,Randy R. Brutkiewicz,Janice S. Blum,Scott Cooper,Giao Hangoc,Hal E. Broxmeyer
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Immunobiology

CDK6 kinase activity is required for thymocyte development
Miaofen G. Hu,Amit Deshpande,Nicolette Schlichting,Elisabeth A. Hinds,Changchuin Mao,Marei Dose,Guo-fu Hu,Richard A. Van Etten,Fotini Gounari,Philip W. Hinds
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Supplemental data
Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets
Michael Kasperkiewicz,Ralf Müller,Rudolf Manz,Moritz Magens,Christoph M. Hammers,Csaba Somlai,Jürgen Westermann,Enno Schmidt,Detlef Zillikens,Ralf J. Ludwig,Antal Orosz
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Insights into the regulatory mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies
Dhohyung Kim,Devra Huey,Michael Oglesbee,Stefan Niewiesk
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Advanced glycation end products of human β2 glycoprotein I modulate the maturation and function of DCs
Brigitta Buttari,Elisabetta Profumo,Antonella Capozzi,Francesco Facchiano,Luciano Saso,Maurizio Sorice,Rachele Riganò
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Supplemental data
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival
Rogier M. Reijmers,Richard W. J. Groen,Annemieke Kuil,Kees Weijer,Fiona C. Kimberley,Jan Paul Medema,Toin H. van Kuppevelt,Jin-Ping Li,Marcel Spaargaren,Steven T. Pals
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Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality
Yaping Sun,Sooryanarayana Varambally,Christopher A. Maher,Qi Cao,Peter Chockley,Tomomi Toubai,Chelsea Malter,Evelyn Nieves,Isao Tawara,Yongqing Wang,Peter A. Ward,Arul Chinnaiyan,Pavan Reddy
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Supplemental data
Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2−/−γ C−/− mice in vivo
Liguo Zhang,Qi Jiang,Guangming Li,Jerry Jeffrey,Grigoriy I. Kovalev,Lishan Su
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Supplemental data
NFIL3/E4BP4 is a key transcription factor for CD8α+ dendritic cell development
Brief Report
Masaki Kashiwada,Nhat-Long L. Pham,Lecia L. Pewe,John T. Harty,Paul B. Rothman
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Supplemental data

Lymphoid Neoplasia

HIV-1–related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence and evolution of CD4+ T-cell lymphocytes
Clinical Trials & Observations
Julia Bohlius,Kurt Schmidlin,François Boué,Gerd Fätkenheuer,Margaret May,Ana Maria Caro-Murillo,Amanda Mocroft,Fabrice Bonnet,Gary Clifford,Vassilios Paparizos,Jose M. Miro,Niels Obel,Maria Prins,Geneviève Chêne,Matthias Egger,Collaboration of Observational HIV Epidemiological Research Europe
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Supplemental data
Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC
Clinical Trials & Observations
Laurent Sutton,Sylvie Chevret,Olivier Tournilhac,Marine Diviné,Véronique Leblond,Bernadette Corront,Stéphane Leprêtre,Houchingue Eghbali,Eric Van Den Neste,Mauricette Michallet,Frédéric Maloisel,Krimo Bouabdallah,Didier Decaudin,Christian Berthou,Pauline Brice,Hugo Gonzalez,Elise Chapiro,Isabelle Radford-Weiss,Nathalie Leporrier,Karim Maloum,Florence Nguyen-Khac,Frédéric Davi,Julie Lejeune,Hélène Merle-Béral,Michel Leporrier,for the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and Groupe Français d'étude de la Leucémie Lymphoïde Chronique (GFLLC)
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Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion
Paola Neri,Li Ren,Abdel Kareem Azab,Matthew Brentnall,Kathy Gratton,Alexander C. Klimowicz,Charles Lin,Peter Duggan,Pierfrancesco Tassone,Adnan Mansoor,Douglas A. Stewart,Lawrence H. Boise,Irene M. Ghobrial,Nizar J. Bahlis
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Supplemental data
The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity
Rathiga Velaithan,Jia Kang,Jayshree L. Hirpara,Thomas Loh,Boon Cher Goh,Morgane Le Bras,Catherine Brenner,Marie-Veronique Clement,Shazib Pervaiz
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Supplemental data
Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1
Vanessa J. Craig,Sergio B. Cogliatti,Jochen Imig,Christoph Renner,Stefan Neuenschwander,Hubert Rehrauer,Ralph Schlapbach,Stephan Dirnhofer,Alexander Tzankov,Anne Müller
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Supplemental data
Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNFα/NFκB pathway
Hanan Armanious,Pascal Gelebart,Mona Anand,Andrew Belch,Raymond Lai
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Supplemental data
Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia
Frederik W. van Delft,Sharon Horsley,Sue Colman,Kristina Anderson,Caroline Bateman,Helena Kempski,Jan Zuna,Cornelia Eckert,Vaskar Saha,Lyndal Kearney,Anthony Ford,Mel Greaves
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Supplemental data
Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway
María J. Bueno,Marta Gómez de Cedrón,Gonzalo Gómez-López,Ignacio Pérez de Castro,Lorena Di Lisio,Santiago Montes-Moreno,Nerea Martínez,Manuel Guerrero,Ruth Sánchez-Martínez,Javier Santos,David G. Pisano,Miguel Angel Piris,José Fernández-Piqueras,Marcos Malumbres
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Supplemental data
New markers for minimal residual disease detection in acute lymphoblastic leukemia
Elaine Coustan-Smith,Guangchun Song,Christopher Clark,Laura Key,Peixin Liu,Mohammad Mehrpooya,Patricia Stow,Xiaoping Su,Sheila Shurtleff,Ching-Hon Pui,James R. Downing,Dario Campana
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Supplemental data
Circulating human B lymphocytes are deficient in nucleotide excision repair and accumulate mutations upon proliferation
Nevila Hyka-Nouspikel,Kimon Lemonidis,Wei-Ting Lu,Thierry Nouspikel
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Supplemental data
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
Sarah E. M. Herman,Amber L. Gordon,Erin Hertlein,Asha Ramanunni,Xiaoli Zhang,Samantha Jaglowski,Joseph Flynn,Jeffrey Jones,Kristie A. Blum,Joseph J. Buggy,Ahmed Hamdy,Amy J. Johnson,John C. Byrd
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Bortezomib induction of C/EBPβ mediates Epstein-Barr virus lytic activation in Burkitt lymphoma
Courtney M. Shirley,Jianmeng Chen,Meir Shamay,Huili Li,Cynthia A. Zahnow,S. Diane Hayward,Richard F. Ambinder
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Myeloid Neoplasia

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells
Shunya Arai,Akihide Yoshimi,Munetake Shimabe,Motoshi Ichikawa,Masahiro Nakagawa,Yoichi Imai,Susumu Goyama,Mineo Kurokawa
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Supplemental data
Long-term risk for subsequent leukemia after treatment for childhood cancer: a report from the Childhood Cancer Survivor Study
Brief Report
Kerri Nottage,Jennifer Lanctot,Zhenghong Li,Joseph P. Neglia,Smita Bhatia,Sue Hammond,Wendy Leisenring,Anna Meadows,Deokumar Srivastava,Leslie L. Robison,Gregory T. Armstrong
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Platelets and Thrombopoiesis

Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms
Arunima Ghosh,Gurunathan Murugesan,Kan Chen,Li Zhang,Qing Wang,Maria Febbraio,Rita Marie Anselmo,Kandice Marchant,John Barnard,Roy L. Silverstein
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Supplemental data

Red Cells, Iron, and Erythropoiesis

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis
Wenjie Chen,Franklin W. Huang,Tomasa Barrientos de Renshaw,Nancy C. Andrews
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Supplemental data
Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II
Matthew Ndonwi,Oname O. Burlingame,Aaron S. Miller,Douglas M. Tollefsen,George J. Broze, Jr,Daniel E. Goldberg
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Supplemental data
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
e-blood
Johannes Schödel,Spyros Oikonomopoulos,Jiannis Ragoussis,Christopher W. Pugh,Peter J. Ratcliffe,David R. Mole
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Supplemental data

Thrombosis and Hemostasis

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A
Matthew J. Flick,Anil K. Chauhan,Malinda Frederick,Kathryn E. Talmage,Keith W. Kombrinck,Whitney Miller,Eric S. Mullins,Joseph S. Palumbo,Xunzhen Zheng,Naomi L. Esmon,Charles T. Esmon,Sherry Thornton,Ann Becker,Leslie A. Pelc,Enrico Di Cera,Denisa D. Wagner,Jay L. Degen
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Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain
Reto A. Schuepbach,Kara Velez,Matthias Riewald
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Supplemental data
Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom
Brief Report
Charles R.M. Hay,Ben Palmer,Elizabeth Chalmers,Ri Liesner,Rhona Maclean,Savita Rangarajan,Michael Williams,Peter W. Collins,on behalf of United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO)
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The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking
Brief Report
Steven R. Fraser,Nuala A. Booth,Nicola J. Mutch
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Transplantation

Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti–T-cell globulin ATG-Fresenius
Clinical Trials & Observations
Gérard Socié,Claudia Schmoor,Wolfgang A. Bethge,Hellmut D. Ottinger,Matthias Stelljes,Axel R. Zander,Liisa Volin,Tapani Ruutu,Dominik A. Heim,Rainer Schwerdtfeger,Karin Kolbe,Jiri Mayer,Johan A. Maertens,Werner Linkesch,Ernst Holler,Vladimir Koza,Martin Bornhäuser,Hermann Einsele,Hans-Jochem Kolb,Hartmut Bertz,Matthias Egger,Olga Grishina,Jürgen Finke,for the ATG-Fresenius Trial Group
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Supplemental data

Vascular Biology

Endothelial cell activation by antiphospholipid antibodies is modulated by Krüppel-like transcription factors
Kristi L. Allen,Anne Hamik,Mukesh K. Jain,Keith R. McCrae
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Supplemental data
Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways
Yang Chen,Shan Wang,Xinan Lu,Haoran Zhang,Yan Fu,Yongzhang Luo
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Supplemental data
  • Cover Image

    Cover Image

    issue cover

    The cover image shows how maternal IgG antibodies inhibit B-cell responses by cross-linking the B-cell receptor (BCR; membrane-bound Ig in green in the center) with the inhibitory Fc receptor (FcγRIIB; in brown on the left) through a measles vaccine virus–IgG complex. This inhibition can be partially overcome by cross-linking the B-cell receptor with the stimulatory complement receptor 2 (CD21/CD19/CD81/Leu-13; in green and blue to the right) through a measles vaccine virus–IgM (pentameter in purple)–complement C3d protein (orange) complex. (Illustration by Tim Vojt, Medical Illustrator, The Ohio State University.) See the full article by Kim et al on page 6143.

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