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Volume 115, Issue 4

January 28 2010

Blood Cover Image for Volume 115, Issue 4

In this Issue

INSIDE BLOOD
EDITORIALS
PLENARY PAPERS
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
VASCULAR BIOLOGY
CORRESPONDENCE
OTHER DEPARTMENTS

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS

Scl and stem cell quiescence

Brian P. Sorrentino

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CLINICAL TRIALS

PET positive, PET negative, or PET peeve?

Jonathan W. Friedberg

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THROMBOSIS & HEMOSTASIS

Platelet factor V to the rescue

Rodney M. Camire

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TRANSPLANTATION

UCB and atmospheric noise

Michael R. Verneris,John E. Wagner

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EDITORIALS

Keeping up with Blood: introducing our CME program

Georgia B. Vogelsang,Cynthia E. Dunbar, MD

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PLENARY PAPERS

Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8⁺ T-cell response against the nonengrafted unit

Jonathan A. Gutman,Cameron J. Turtle,Thomas J. Manley,Shelly Heimfeld,Irwin D. Bernstein,Stanley R. Riddell,Colleen Delaney

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REVIEW ARTICLES

Dysregulation of bone remodeling by imatinib mesylate

Kate Vandyke,Stephen Fitter,Andrea L. Dewar,Timothy P. Hughes,Andrew C. W. Zannettino

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CLINICAL TRIALS AND OBSERVATIONS

Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study
CME

Sandra J. Horning,Malik E. Juweid,Heiko Schöder,Gregory Wiseman,Alex McMillan,Lode J. Swinnen,Ranjana Advani,Randy Gascoyne,Andrew Quon

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Thrombosis in primary myelofibrosis: incidence and risk factors
Clinical Trials & Observations

Tiziano Barbui,Alessandra Carobbio,Francisco Cervantes,Alessandro M. Vannucchi,Paola Guglielmelli,Elisabetta Antonioli,Alberto Alvarez-Larrán,Alessandro Rambaldi,Guido Finazzi,Giovanni Barosi

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GENE THERAPY

Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils

Elizabeth M. Kang,Uimook Choi,Narda Theobald,Gilda Linton,Debra A. Long Priel,Doug Kuhns,Harry L. Malech

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Supplemental data

HEMATOPOIESIS AND STEM CELLS

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

Julie Lacombe,Sabine Herblot,Shanti Rojas-Sutterlin,André Haman,Stéphane Barakat,Norman N. Iscove,Guy Sauvageau,Trang Hoang

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Supplemental data

IMMUNOBIOLOGY

Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners

Yukihiko Ebisuno,Koko Katagiri,Tomoya Katakai,Yoshihiro Ueda,Tomomi Nemoto,Hiroyuki Inada,Junichi Nabekura,Takaharu Okada,Reiji Kannagi,Toshiyuki Tanaka,Masayuki Miyasaka,Nancy Hogg,Tatsuo Kinashi

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Supplemental data

LYMPHOID NEOPLASIA

Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit model

Rashade A. H. Haynes, II,Evan Ware,Christopher Premanandan,Bevin Zimmerman,Lianbo Yu,Andrew J. Phipps,Michael D. Lairmore

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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

Ying-Wei Lin,Zanna M. Beharry,Elizabeth G. Hill,Jin H. Song,Wenxue Wang,Zuping Xia,Zhenhua Zhang,Peter D. Aplan,Jon C. Aster,Charles D. Smith,Andrew S. Kraft

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Supplemental data

Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma

Dharminder Chauhan,Ajita V. Singh,Bryan Ciccarelli,Paul G. Richardson,Michael A. Palladino,Kenneth C. Anderson

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Supplemental data

VEGF/VEGFR2 interaction down-regulates matrix metalloproteinase–9 via STAT1 activation and inhibits B chronic lymphocytic leukemia cell migration
Brief Report

Estefanía Ugarte-Berzal,Javier Redondo-Muñoz,Pilar Eroles,Mercedes Hernández del Cerro,José A. García-Marco,María José Terol,Angeles García-Pardo

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Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Tumor necrosis factor–related apoptosis-inducing ligand 1 (TRAIL1) enhances the transition of red blood cells from the larval to adult type during metamorphosis in Xenopus

Kei Tamura,Shuuji Mawaribuchi,Shin Yoshimoto,Tadayoshi Shiba,Nobuhiko Takamatsu,Michihiko Ito

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Supplemental data

Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery

Daniel R. Crooks,Manik C. Ghosh,Ronald G. Haller,Wing-Hang Tong,Tracey A. Rouault

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THROMBOSIS AND HEMOSTASIS

Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants

Katrien Devreese,Kathelijne Peerlinck,Marc F. Hoylaerts

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Supplemental data

Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms

Connie Duckers,Paolo Simioni,Luca Spiezia,Claudia Radu,Paolo Dabrilli,Sabrina Gavasso,Jan Rosing,Elisabetta Castoldi

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VASCULAR BIOLOGY

KSHV-induced notch components render endothelial and mural cell characteristics and cell survival

Ren Liu,Xiuqing Li,Anil Tulpule,Yue Zhou,Jeffrey S. Scehnet,Shaobing Zhang,Jong-Soo Lee,Preet M. Chaudhary,Jae Jung,Parkash S. Gill

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Supplemental data

Induction of nitric oxide by erythropoietin is mediated by the β common receptor and requires interaction with VEGF receptor 2

Larysa Sautina,Yuri Sautin,Elaine Beem,Zhuo Zhou,Anna Schuler,Jennafer Brennan,Sergey I. Zharikov,YanPeng Diao,Jorg Bungert,Mark S. Segal

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Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
Brief Report

Camilla Norrmén,Wouter Vandevelde,Annelii Ny,Pipsa Saharinen,Massimiliano Gentile,Guttorm Haraldsen,Pauli Puolakkainen,Eugene Lukanidin,Mieke Dewerchin,Kari Alitalo,Tatiana V. Petrova

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Supplemental data

CORRESPONDENCE

G-CSF–induced aneuploidy does not affect CD34⁺ cells and does not require cell division

Caroline Marmier-Savet,Fabrice Larosa,Faezeh Legrand,Brigitte Witz,Mauricette Michallet,Dana Ranta,Pascale Louvat,Marc Puyraveau,Nicole Raus,Maribel Tavernier,Suzanne Mathieu-Nafissi,Olivier Hequet,Jean-René Pallandre,Franck Vitte,Marie-Agnès Collonge-Rame,Fabienne Pouthier,Jean-Luc Bresson,Eric Deconinck,Pierre Tiberghien,Eric Robinet

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Friday leukemia: myth or reality?

Stefan Wilop,Oliver Galm,Laura Thompson,Rainhardt Osieka,Tim H. Brummendorf,Edgar Jost

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Mutational analysis of SHOC2, a novel gene for Noonan-like syndrome, in JMML

Christian Flotho,Christiane Batz,Henrik Hasle,Eva Bergsträsser,Marry M. van den Heuvel-Eibrink,Marco Zecca,Charlotte M. Niemeyer,Martin Zenker

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A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia

Renhao Li

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Successful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib

Kenneth R. Carson,Lee G. Beckwith,Jayesh Mehta

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Plerixafor-moblized stem cells alone are capable of inducing early engraftment across the MHC-haploidentical canine barrier

Monica S. Thakar,Erlinda B. Santos,Simon Fricker,Gary Bridger,Rainer Storb,Brenda M. Sandmaier

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OTHER DEPARTMENTS

Continuing Medical Education (CME) questions: PET scans in B-cell lymphoma
CME

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Cover Image

Cover Image

Hypothetical schema for the effects of the tyrosine kinase inhibitor imatinib on bone metabolism. Imatinib causes increased bone volume by inhibiting osteoclast (OC) formation and activity and increasing osteoblast (OB) activity. The inhibitory effects of imatinib on signaling through c-fms and, potentially, c-kit, CAII, and PDGFR decreases the formation and activity of bone-resorbing OC. Additionally, inhibition of PDGFR by imatinib inhibits OB proliferation but also relieves the inhibitory effects of PDGF on OB bone formation. See the article by Vandyke et al on page 766.
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