Abstract

DNMT3A mutations in patients with polycythemia vera were heterogeneous and not enriched in interferon alfa–treated patients. DNMT3A mutations had no detectable impact on the hematologic response, molecular response, or survival outcomes.

1.
Usart
M
,
Stetka
J
,
Luque Paz
D
, et al
.
Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2-V617F–positive myeloproliferative neoplasms
.
Blood
.
2024
;
143
(
24
):
2490
-
2503
.
2.
Knudsen
TA
,
Skov
V
,
Stevenson
K
, et al
.
Genomic profiling of a randomized trial of interferon-α vs hydroxyurea in MPN reveals mutation-specific responses
.
Blood Adv
.
2022
;
6
(
7
):
2107
-
2119
.
3.
Abu-Zeinah
G
,
Krichevsky
S
,
Cruz
T
, et al
.
Interferon-alpha for treating polycythemia vera yields improved myelofibrosis-free and overall survival
.
Leukemia
.
2021
;
35
(
9
):
2592
-
2601
.
4.
Gisslinger
H
,
Klade
C
,
Georgiev
P
, et al
.
Event-free survival in patients with polycythemia vera treated with ropeginterferon alfa-2b versus best available treatment
.
Leukemia
.
2023
;
37
(
10
):
2129
-
2132
.
5.
Silver
RT
.
Recombinant interferon-alpha for treatment of polycythaemia vera
.
Lancet
.
1988
;
2
(
8607
):
403
.
6.
Barosi
G
,
Mesa
R
,
Finazzi
G
, et al
.
Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project
.
Blood
.
2013
;
121
(
23
):
4778
-
4781
.
7.
Cerami
E
,
Gao
J
,
Dogrusoz
U
, et al
.
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
.
Cancer Discov
.
2012
;
2
(
5
):
401
-
404
.
8.
Tefferi
A
,
Guglielmelli
P
,
Lasho
TL
, et al
.
Mutation-enhanced international prognostic systems for essential thrombocythaemia and polycythaemia vera
.
Br J Haematol
.
2020
;
189
(
2
):
291
-
302
.
9.
Gisslinger
H
,
Klade
C
,
Georgiev
P
, et al
.
Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study
.
Lancet Haematol
.
2020
;
7
(
3
):
e196
-
e208
.
10.
Barosi
G
,
Birgegard
G
,
Finazzi
G
, et al
.
Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference
.
Blood
.
2009
;
113
(
20
):
4829
-
4833
.
11.
Williams
N
,
Lee
J
,
Mitchell
E
, et al
.
Life histories of myeloproliferative neoplasms inferred from phylogenies
.
Nature
.
2022
;
602
(
7895
):
162
-
168
.
12.
Constantinescu
SN
,
Vainchenker
W
.
DNMT3A gates IFN-induced MPN HSC exhaustion
.
Blood
.
2024
;
143
(
24
):
2445
-
2446
.
13.
Xavier Raj
I
,
Koh
WK
,
Harrison
J
, et al
.
Dnmt3a controls hematopoietic stem cells via DNA methylation-independent regulation of telomeres [abstract]
.
Blood
.
2024
;
144
(
suppl 1
):
25
.
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