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Immunobiology and Immunotherapy
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Journal Articles

Patient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states

Open Access
Diego Butera, Aster E. Pijning, Nathan G. Avery, Carmen H. Coxon, Clive Metcalfe, Angelina Mimoun, Sébastien Lacroix-Desmazes, Paul Clint Spiegel, Jr., Philip J. Hogg
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3706–3715.
https://doi.org/10.1182/bloodadvances.2025016474
Published: 2025
Includes: Supplemental data
Journal Articles

T-cell dysfunction during blinatumomab therapy in pediatric acute lymphoblastic leukemia

Open Access
Julie Ma, Annie Luong, Andrew Doan, Tsen Yin Lin, Lingyun Ji, Cassandra P. Wang, Seon-Jae Yoon, Teresa Rushing, Anh Duong, Miguel Villa, Chintan Parekh
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3689–3693.
https://doi.org/10.1182/bloodadvances.2025015894
Published: 2025
Includes: Supplemental data
Journal Articles

HLA-E[pHLA-G] Complex Specific Monoclonal Antibody Enhancing NK Activity in Multiple Myeloma

Open Access
Muhammad Abu Ahmad, Olga Radinsky, Bar Kaufman, Kamran Waidha, Eman Gharra, Sharon Dim, Dinesh Babu Manikandan, Noa Ofir, Dirk Jäger, Marten Meyer, Moshe Elkabets, Kerry S. Campbell, Miri Zektser, Roi Gazit, Ory Rouvio, Frank Momburg, Angel Porgador
Journal: Blood Advances
Blood Adv bloodadvances.2025016276.
https://doi.org/10.1182/bloodadvances.2025016276
Published: 2025
Includes: Supplemental data
Journal Articles

Characterization and prediction of hematotoxicity in pediatric patients receiving tisagenlecuecel

Open Access
Swati Naik, Subodh Selukar, Aimee C Talleur, Samira Deshpande, Gabriela Llaurador Caraballo, Vanessa A. Fabrizio, Rayne H Rouce, Xiaopei Lily Zeng, Anant Vatsayan, Jenna Rossoff, Holly L Pacenta, Samuel John, Christine L. Phillips, Julie-An M. Talano, Amy Moskop, Michael R Verneris, Gary Douglas Myers, Erin M. Hall, Nicole A. Karras, Challice L Bonifant, Muna Qayed, Emily Bakinowski, Amy Keating, Susanne H.C. Baumeister, Emily Tomilson, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Vasant Chinnabhandar, Heather E Stefanski, Emily Egeler, Kevin J. Curran, Theodore W. Laetsch, Crystal L. Mackall, Snehit Prabhu, Khanh Nguyen, Christina Baggott, Liora M. Schultz, Kevin O. McNerney
Journal: Blood Advances
Blood Adv bloodadvances.2025016824.
https://doi.org/10.1182/bloodadvances.2025016824
Published: 2025
Includes: Supplemental data
Journal Articles

Interferon gamma rebalances immunopathological signatures in Chronic Granulomatous Disease through metabolic rewiring

Open Access
Mariolina Bruno, Charlotte Kröger, Anaísa V. Ferreira, Bowen Zhang, Rutger J. Röring, Ruiqi Liu, Caspar I. van der Made, Norman van Rhijn, Lazslo Groh, Viola Klück, Nico A.F. Janssen, Wenchao Li, Diletta Rosati, Ahmed Alaswad, Helin Tercan, Jorge Saiz, Carolina Gonzalez-Riano, Martina van Uelft, Orsi Gaal, Sophie Müller, Humberto J. Ferreira, Stefanie Warnat-Herresthal, Matthias Becker, Lisa Holsten, Michael Kraut, Jonas Schulte-Schrepping, Lorenzo Bonaguro, Kristian Händler, Cristina Cunha, Manfred Schmolz, Joachim L Schultze, Leo Joosten, Coral Barbas, Mihai G Netea, Yang Li, Anna C. Aschenbrenner, Agostinho Carvalho, Frank L. van de Veerdonk
Journal: Blood Advances
Blood Adv bloodadvances.2025016213.
https://doi.org/10.1182/bloodadvances.2025016213
Published: 2025
Includes: Supplemental data
Journal Articles

Population-based validation of the CAR-HEMATOTOX for hematotoxicity, infections and survival after CART in R/R LBCL

Open Access
Janneke W de Boer, Kylie Keijzer, Suzanne van Dorp, Pim G.N.J. Mutsaers, Anne GH Niezink, Jaap A van Doesum, Yasmina IM Serroukh, Louise W Muntendam, Astrid E Pulles, Esther J Kret, Aniko Sijs-Szabo, Jesse Oomen, Astrid MP Demandt, Wendy BC Stevens, Maria T Kuipers, Elise RA Pennings, Anne Mea Spanjaart, Marie José Kersten, Margot Jak, Lisanne Vania van Dijk, Marjolein WM van der Poel, Joost SP Vermaat, Tom van van Meerten
Journal: Blood Advances
Blood Adv bloodadvances.2025016689.
https://doi.org/10.1182/bloodadvances.2025016689
Published: 2025
Includes: Supplemental data
Journal Articles

Intrathecal chemotherapy for ciltacabtagene autoleucel–associated movement and neurocognitive toxicity

Open Access
Kaitlin Kelly, Jennifer H. Cooperrider, Michael R. Bishop, Satyajit Kosuri, Andrzej Jakubowiak, Benjamin A. Derman
Journal: Blood Advances
Blood Adv (2025) 9 (14): 3613–3616.
https://doi.org/10.1182/bloodadvances.2024015721
Published: 2025
Includes: Supplemental data
Journal Articles

Transplant outcomes using older matched sibling donors compared with young alternative donors: a CIBMTR analysis

Open Access
Karthik Nath, Mei-Jie Zhang, Matthew Bye, Muhammad Bilal Abid, Cara Benjamin, Brian Betts, Neel S. Bhatt, Esteban Arrieta Bolaños, Yung-Tsi Bolon, Shahinaz M. Gadalla, Michael R. Grunwald, Maxwell M. Krem, Stephanie J. Lee, Steven G. E. Marsh, Rodrigo Martino, Parinda A. Mehta, Filippo Milano, Timothy Prestidge, Jennifer N. Saultz, Bronwen E. Shaw, Stephen R. Spellman, Hannah Choe, Brian C. Shaffer
Journal: Blood Advances
Blood Adv (2025) 9 (14): 3469–3478.
https://doi.org/10.1182/bloodadvances.2024014858
Published: 2025
Includes: Supplemental data
Journal Articles

Antibiotic use: impact on the microbiome and cellular therapy outcomes

Open Access
Alicia Darwin, Jiayi Xie, Melody Smith
Journal: Blood Advances
Blood Adv (2025) 9 (13): 3356–3367.
https://doi.org/10.1182/bloodadvances.2024013809
Published: 2025
Journal Articles

Nivolumab plus relatlimab for patients with relapsed or progressed B-cell malignancies in RELATIVITY-022

Open Access
Clinical Trials & Observations
Ajay K. Gopal, Philippe Armand, Sattva S. Neelapu, Nancy L. Bartlett, Stephen E. Spurgeon, John Kuruvilla, Kerry J. Savage, John P. Leonard, Arnold B. Gelb, Nasir Ahmed, Shiqi Dong, Sai Praneeth Bathena, Rasika Suryawanshi, Jenny Qun Wu, Sheen Wang, Douglas E. Gladstone
Journal: Blood Advances
Blood Adv (2025) 9 (13): 3383–3394.
https://doi.org/10.1182/bloodadvances.2024015086
Published: 2025
Includes: Supplemental data
Journal Articles

Throwing the microbiome out with the bathwater

Open Access
Marcus Geer, Mary Riwes
Journal: Blood Advances
Blood Adv (2025) 9 (13): 3368–3369.
https://doi.org/10.1182/bloodadvances.2025016205
Published: 2025
Journal Articles

Mature megakaryocytes acquire immune characteristics in a mouse model of aplastic anemia

Open Access
Ashvind Prabahran, Liangliang Wu, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Hiroki Mizumaki, Valentina Baena, Zulfeqhar Syed, Christian A. Combs, Jichun Chen, Xingmin Feng, Neal S. Young
Journal: Blood Advances
Blood Adv (2025) 9 (13): 3315–3330.
https://doi.org/10.1182/bloodadvances.2024015621
Published: 2025
Includes: Supplemental data
Journal Articles

Expression and treatment of ROR1 + cells with bispecific T-cell engagers in pediatric acute lymphoblastic leukemia

Open Access
Paraskevi Diamanti, Bethan K. Bailey, Obinna E. Iheanacho, John P. Moppett, Amit C. Nathwani, Allison Blair
Journal: Blood Advances
Blood Adv (2025) 9 (13): 3190–3201.
https://doi.org/10.1182/bloodadvances.2024013814
Published: 2025
Includes: Supplemental data
Journal Articles

Immunological consequences of CAR T-cell therapy: an analysis of infectious complications and immune reconstitution

Open Access
Clinical Trials & Observations
Andreas Riedel, Laurent Phely, Stefan Hug, Philipp Faustmann, Jan Christian Schroeder, Britta Besemer, Anna M. Paczulla Stanger, Christoph Faul, Claudia Lengerke, Jan Frederic Weller, Wolfgang Bethge
Journal: Blood Advances
Blood Adv (2025) 9 (13): 3149–3158.
https://doi.org/10.1182/bloodadvances.2024015346
Published: 2025
Includes: Supplemental data
Journal Articles

Invasive fungal disease is rare in patients with relapsed/refractory multiple myeloma treated with BCMA CAR T-cell therapy

Open Access
Jessica S. Little, Angelica Medina Pena, E. Bridget Kim, Andrew J. Yee, Omar Nadeem, Shonali Midha, Adam S. Sperling, Nikhil C. Munshi, Noopur S. Raje, Matthew J. Frigault, Diana D. Cirstea, Sarah P Hammond
Journal: Blood Advances
Blood Adv bloodadvances.2025016748.
https://doi.org/10.1182/bloodadvances.2025016748
Published: 2025
Includes: Supplemental data
Journal Articles

Point-of-care fresh CAR T cells for pediatric or young adult BCP-ALL that is relapsed/refractory or in very-high-risk first relapse

Open Access
Francesca Del Bufalo, Marco Becilli, Chiara Rosignoli, Pietro Merli, Mattia Algeri, Daria Pagliara, Federica Galaverna, Michele Massa, Valeria Paganelli, Maria Giuseppina Cefalo, Linda Hanssens, Valentina Bertaina, Giuseppina Li Pira, Giovanna Leone, Dr, Matilde Sinibaldi, Stefano Di Cecca, Laura Iaffaldano, Valentina Fustaino, Biagio De Angelis, Concetta Quintarelli, Franco Locatelli
Journal: Blood Advances
Blood Adv bloodadvances.2025016181.
https://doi.org/10.1182/bloodadvances.2025016181
Published: 2025
Includes: Supplemental data
Journal Articles

Current developments in T-cell receptor therapy for acute myeloid leukemia

Open Access
Sayali Gore, Emily Blyth, Marie Bleakley, Koon Lee, Kenneth Micklethwaite, Kavitha Gowrishankar
Journal: Blood Advances
Blood Adv (2025) 9 (12): 3069–3089.
https://doi.org/10.1182/bloodadvances.2024014105
Published: 2025
Journal Articles

The impact of CMV reactivation on mortality after chimeric antigen receptor T-cell therapy

Open Access
Clinical Trials & Observations
Eleftheria Kampouri, Patrick Flaherty, Hu Xie, Mandeep K. Sekhon, Clementine Chalal, Terry L. Stevens-Ayers, Damian J. Green, Jordan Gauthier, Mazyar Shadman, Ailyn C. Pérez-Osorio, Keith R. Jerome, Wendy M. Leisenring, Michael J. Boeckh, Joshua A. Hill
Journal: Blood Advances
Blood Adv (2025) 9 (12): 2997–3001.
https://doi.org/10.1182/bloodadvances.2024015164
Published: 2025
Includes: Supplemental data
Journal Articles

Extracellular vesicles for CAR T-cell therapy immunomonitoring

Open Access
Marion Klea Pinheiro, Benoît Vingert
Journal: Blood Advances
Blood Adv (2025) 9 (12): 2920–2921.
https://doi.org/10.1182/bloodadvances.2025015988
Published: 2025
Journal Articles

AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling

Open Access
Alexander Zähringer, Inês Morgado, Daniel Erny, Florian Ingelfinger, Jana Gawron, Sangya Chatterjee, Valentin Wenger, Dominik Schmidt, Lennard Schwöbel, Rachael C. Adams, Marlene Langenbach, Alina Hartmann, Natascha Osswald, Julian Wolf, Günther Schlunck, Priscilla S. Briquez, Kathleen Grueter, Dietrich A. Ruess, Ian Frew, Ann-Cathrin Burk, Verena Holzmüller, Bodo Grimbacher, David Michonneau, Geoffroy Andrieux, Gérard Socié, Julia Kolter, Melanie Boerries, Marie Follo, Franziska Blaeschke, Lisa Sevenich, Marco Prinz, Robert Zeiser, Janaki Manoja Vinnakota
Journal: Blood Advances
Blood Adv (2025) 9 (12): 2935–2952.
https://doi.org/10.1182/bloodadvances.2024015000
Published: 2025
Includes: Supplemental data