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Journal Articles

Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma

Shirong Li, Jing Fu, Jun Yang, Huihui Ma, Divaya Bhutani, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch

Blood (2021) 137 (13): 1754–1764.

https://doi.org/10.1182/blood.2020006334

Published: 2021

Includes: Supplemental data

Journal Articles

Protein Cysteine Sulfenylation By CD36-Dependent Reactive Oxygen Species Signaling Promotes Platelet Activation

Moua Yang, PhD, Calvin Harberg, Wenjing Chen, Sarah L. Wynia-Smith, PhD, Kate S. Carroll, PhD, Jacek Zielonka, PhD, Roy L. Silverstein, MD, Brian C. Smith, PhD

Blood (2019) 134 (Supplement_1): 2338.

https://doi.org/10.1182/blood-2019-122465

Published: 2019

Journal Articles

Effects of Actr2 gene Variants on Mouse Viability, Gene Expression, and Cytoskeletal Dynamics

Linzi M Hobbs, BS, Amy E Siebert, PhD, Alexander J Johnston, BS, Marisa A Brake, BSc, Vakharia Paras, PharmD, MD, Cleuren Audrey, PhD, Guojing Zhu, MD, Randal J Westrick, PhD

Blood (2019) 134 (Supplement_1): 2340.

https://doi.org/10.1182/blood-2019-131004

Published: 2019

Journal Articles

A Novel Chemical Compound Inhibiting Hematopoietic Cell Kinase (iHCK) Has a Synergic Effect with Azacytidine (Aza) or Cytarabine (Ara-C) for Acute Myeloid Leukemia Treatment

Fernanda Marconi Roversi, Maura Lima Pereira Bueno, undergraduate, Cristiane Okuda Torello, PhD, Fernanda I Della Via, MSc, Renata Giardini Rosa, PhD, Juares Ednaldo Romero Bianco, PhD, Adriana Silva Santos Duarte, PhD, Eduardo M Rego, MD PhD, Alessio Molinari, Maurizio Botta, Sara T Olalla Saad, PhD

Blood (2019) 134 (Supplement_1): 4650.

https://doi.org/10.1182/blood-2019-128959

Published: 2019

Journal Articles

Investigation of New Therapeutic Compounds for Juvenile Myelomonocytic Leukemia Using Induced Pluripotent Stem Cells with Stably Activated Ras Pathway

Lisa Maria Kuhn, Cyrill Schipp, PhD, Daniel Hein, PhD, Bianca Killing, Nan Qin, PhD, Vera H Jepsen, M.Sc., Heinz Ahlert, MSc, BSc, Jasmin Bartl, PhD, Viktoria Marquardt, M.Sc., David Pauck, Kai Völtzke, M.Sc., Jonathan Lim, PhD, Gabriel Leprivier, PhD, Marc Remke, MD, Sanil Bhatia, PhD, Thorsten Rosenbaum, MD, Arndt Borkhardt, MD, Ute Fischer, PhD

Blood (2019) 134 (Supplement_1): 4651.

https://doi.org/10.1182/blood-2019-131406

Published: 2019

Journal Articles

The Anti-Leukemia Effect of Natural Killer-Derived Exosomes

Michael Anbar, PhD, Galit Granot, PhD, Pia Raanani, MD, Uri Rozovski, MD

Blood (2019) 134 (Supplement_1): 4652.

https://doi.org/10.1182/blood-2019-129986

Published: 2019

Journal Articles

Novel CD33 Antibodies Unravel Localization, Biology, and Therapeutic Implications of CD33 Isoforms

Mohammed Gbadamosi, BS, Tiffany A. Hylkema, BS, Soheil Meshinchi, MD PhD, Jatinder K Lamba, M.Sc., PhD

Blood (2019) 134 (Supplement_1): 908.

https://doi.org/10.1182/blood-2019-122596

Published: 2019

Journal Articles

A New Role of Glutathion Peroxydase 4 in Human Erythroblast Enucleation

Hakim Ouled-Haddou, Kahia Messaoudi, Roggiero Lopes Dos Santos, Candice Carola, MD, Yohann Demont, Alexis Caulier, Pascal Vong, Nicolas Jankovsky, Delphine Lebon, MD, Jessica Platon, Julien Demagny, Nicolas Guillaume, Jean-Pierre Marolleau, MD PhD, Jacques Rochette, MB, DSc, Loïc Garçon

Blood (2019) 134 (Supplement_1): 938.

https://doi.org/10.1182/blood-2019-122161

Published: 2019

Journal Articles

Knockdown of HNF4A Gene Increases Fetal Hemoglobin Synthesis in Hudep-2

Ingrid Grazielle Sousa, BSc, MSc, Priscila Keiko Matsumoto Martin, PhD, Dulcinéia Martins de Albuquerque, BSc, PhD, Carolina Lanaro, BSc, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Fernando Ferreira Costa, MD PhD

Blood (2019) 134 (Supplement_1): 968.

https://doi.org/10.1182/blood-2019-130920

Published: 2019

Journal Articles

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Gregory Lazarian, PharmD, Shanye Yin, PhD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, MSc,PhD, Alba Font-tello, PhD, Heather Joyal, Elizabeth Witten, Mei Zheng, Christopher J. Ott, PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD

Blood (2019) 134 (Supplement_1): 848.

https://doi.org/10.1182/blood-2019-123963

Published: 2019

Journal Articles

The Multidrug Transporter MRP4/ABCC4 Involved in the Leukemia Clinical Course Specifies the Novel PEL Human Blood Group System

Blood (2019) 134 (Supplement_1): 715.

https://doi.org/10.1182/blood-2019-124082

Published: 2019

Journal Articles

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy McGraw, PhD, Amy F McLemore, M.S., Nghi B Lam, M.S., Hsin-An Hou, Benjamin S. Meyer, Alan F. List, MD

Blood (2019) 134 (Supplement_1): 774.

https://doi.org/10.1182/blood-2019-122358

Published: 2019

Journal Articles

Sickle Cell Disease Promotes Dysregulation of Hepatic Iron Homeostasis By Regulating Hepcidin Expression

Tirthadipa Pradhan, Prithu Sundd, PhD, Satdarshan Pal Monga, Mark T Gladwin, MD, Gregory J Kato, MD

Blood (2019) 134 (Supplement_1): 958.

https://doi.org/10.1182/blood-2019-131921

Published: 2019

Journal Articles

Characterizing the Anti-Apoptotic Dependencies of T-Cell Prolymphocytic Leukemia Identifies HDAC and JAK/STAT Pathway Inhibitors As Promising Combination Partners to Augment Bcl-2 Targeted Killing By Venetoclax

Blood (2019) 134 (Supplement_1): 807.

https://doi.org/10.1182/blood-2019-126773

Published: 2019

Journal Articles

Post-Translational Mechanisms of NT5C2 Activation As Non-Genetic Drivers of Chemotherapy Resistance in Relapsed Acute Lymphoblastic Leukemia

Clara Reglero, PhD, Dieck L. Chelsea, PhD, Jui Wan Loh, Hossein Khiabanian, PhD, Adolfo Ferrando, MD, PhD

Blood (2019) 134 (Supplement_1): 728.

https://doi.org/10.1182/blood-2019-128615

Published: 2019

Journal Articles

Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway

Alireza Paikari, MD, Yankai Zhang, PhD, Alicia Chang, MD, Ankush Goyal, MA, Evadnie Rampersaud, PhD, Jonathan M. Flanagan, PhD, Mitchell J. Weiss, MD, PhD, Vivien A. Sheehan, MD PhD

Blood (2019) 134 (Supplement_1): 811.

https://doi.org/10.1182/blood-2019-131313

Published: 2019

Journal Articles

Mutation of the CD28 Co-Stimulatory Domain Confers Enhanced CAR T Cell Function

Justin C. Boucher, PhD, Gongbo Li, PhD MBBS, Hiroshi Kotani, MD PhD, Maria Cabral, Dylan Morrissey, Sae Bom Lee, Kristen Spitler, Nolan Beatty, Bishwas Shrestha, PhD, Bin Yu, Aslamuzzaman Kazi, Xuefeng Wang, PhD, Said Sebti, PhD, Marco L. Davila, MD PhD

Blood (2019) 134 (Supplement_1): 248.

https://doi.org/10.1182/blood-2019-122954

Published: 2019

Journal Articles

KIFC1 Mediates Centrosome Clustering Prior to Proplatelet Formation from Megakaryocytes

Adrian R. Wilkie, PhD, Leila J. Noetzli, PhD, Genevieve Couldwell, Anthony R. Sciaudone, Anjana Ray, PhD, Kellie R. Machlus, PhD, Joseph E. Italiano, Jr., BS, PhD

Blood (2019) 134 (Supplement_1): 721.

https://doi.org/10.1182/blood-2019-130803

Published: 2019

Journal Articles

Addition of the PARP Inhibitor, Talazoparib, to Gemtuzumab Ozogamicin Significantly Enhances Anti-Leukemic Activity in Human CD33+ Acute Myeloid Leukemia

Scott M. Portwood, MBA, MS, Marianna C Cantella, BE, Tara L. Cronin, BA, Eunice S. Wang, MD

Blood (2019) 134 (Supplement_1): 1371.

https://doi.org/10.1182/blood-2019-130427

Published: 2019

Journal Articles

Pipeline for Discovering Neoepitopes Generated By Alternative Splicing in B-ALL

Sisi Zheng, MD, Ammar S. Naqvi, PhD, Elisabeth Bolton-Gillespie, Mukta Asnani, Katharina Hayer, Yoseph Barash, PhD, Andrei Thomas-Tikhonenko, PhD

Blood (2019) 134 (Supplement_1): 1342.

https://doi.org/10.1182/blood-2019-131277

Published: 2019

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Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma

Protein Cysteine Sulfenylation By CD36-Dependent Reactive Oxygen Species Signaling Promotes Platelet Activation

Effects of Actr2 gene Variants on Mouse Viability, Gene Expression, and Cytoskeletal Dynamics

A Novel Chemical Compound Inhibiting Hematopoietic Cell Kinase (iHCK) Has a Synergic Effect with Azacytidine (Aza) or Cytarabine (Ara-C) for Acute Myeloid Leukemia Treatment

Investigation of New Therapeutic Compounds for Juvenile Myelomonocytic Leukemia Using Induced Pluripotent Stem Cells with Stably Activated Ras Pathway

The Anti-Leukemia Effect of Natural Killer-Derived Exosomes

Novel CD33 Antibodies Unravel Localization, Biology, and Therapeutic Implications of CD33 Isoforms

A New Role of Glutathion Peroxydase 4 in Human Erythroblast Enucleation

Knockdown of HNF4A Gene Increases Fetal Hemoglobin Synthesis in Hudep-2

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

The Multidrug Transporter MRP4/ABCC4 Involved in the Leukemia Clinical Course Specifies the Novel PEL Human Blood Group System

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Sickle Cell Disease Promotes Dysregulation of Hepatic Iron Homeostasis By Regulating Hepcidin Expression

Characterizing the Anti-Apoptotic Dependencies of T-Cell Prolymphocytic Leukemia Identifies HDAC and JAK/STAT Pathway Inhibitors As Promising Combination Partners to Augment Bcl-2 Targeted Killing By Venetoclax

Post-Translational Mechanisms of NT5C2 Activation As Non-Genetic Drivers of Chemotherapy Resistance in Relapsed Acute Lymphoblastic Leukemia

Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway

Mutation of the CD28 Co-Stimulatory Domain Confers Enhanced CAR T Cell Function

KIFC1 Mediates Centrosome Clustering Prior to Proplatelet Formation from Megakaryocytes

Addition of the PARP Inhibitor, Talazoparib, to Gemtuzumab Ozogamicin Significantly Enhances Anti-Leukemic Activity in Human CD33+ Acute Myeloid Leukemia

Pipeline for Discovering Neoepitopes Generated By Alternative Splicing in B-ALL

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