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Journal Articles

Spliceosome mutations: 1 plus 1 does not always equal 2

Andrea Pellagatti, Jacqueline Boultwood
Journal: Blood
Blood (2020) 136 (13): 1471–1472.
https://doi.org/10.1182/blood.2020008215
Published: 2020
Journal Articles

UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells

Samantha A. Swenson, Tyler J. Gilbreath, Heather Vahle, R. Willow Hynes-Smith, Jared H. Graham, Henry C.-H. Law, Catalina Amador, Nicholas T. Woods, Michael R. Green, Shannon M. Buckley
Journal: Blood
Blood (2020) 136 (3): 299–312.
https://doi.org/10.1182/blood.2019002102
Published: 2020
Includes: Supplemental data
Journal Articles

The U1 Spliceosomal RNA: A Novel Non-Coding Hotspot Driver Mutation Independently Associated with Clinical Outcome in Chronic Lymphocytic Leukemia

Ferran Nadeu, Shimin Shuai, Ander Diaz-Navarro, Irene López, Silvia Martín, Hiromichi Suzuki, Romina Royo, Guillem Clot, Julio Delgado, Tycho Baumann, Junyan Lu, PhD, Alba Navarro, Marta Kulis, Sachin A Kumar, Ana Gutierrez-Fernandez, Miguel Alcoceba, Marcos González, Enrique Colado, Angel Ramirez Payer, Cristina Capdevila, Miguel Osuna, Marta Aymerich, Rosó Mares, Monica Lopez-Guerra, Laura Magnano, Pablo Mozas, Alfredo Rivas-Delgado, Maria Jose Terol, Anna Enjuanes, Wolfgang Huber, PhD, Armando Lopez-Guillermo, Sílvia Beà, José I. Martin-Subero, Thorsten Zenz, MD, Michael D Taylor, Dolors Colomer, PhD, Xose S Puente, Lincoln D Stein, Elias Campo
Journal: Blood
Blood (2019) 134 (Supplement_1): 847.
https://doi.org/10.1182/blood-2019-130052
Published: 2019
Journal Articles

Mutant U2AF1 S34F and U2AF1 Q157P Induce Distinct RNA Splicing and Hematopoietic Phenotypes In Vivo

Michael O. Alberti, MD PhD, Meng'ou Zhu, BS, Sridhar Nonavinkere Srivatsan, MS, Tanzir Ahmed, PhD, Jin J. Shao, Brian Wadugu, BA, Cara Lunn Shirai, PhD, Matthew J. Walter, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 770.
https://doi.org/10.1182/blood-2019-123892
Published: 2019
Journal Articles

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Acute Myeloid Leukemia Models

Heekyung Chung, PhD, Emily Creger, Lauren Sitts, Kevin Chiu, Chi-Ching Mak, PhD, Sunil KC, PhD, Betty Tam, PhD, Gail Bucci, Josh Stewart, Timothy Phalen, PhD, Steven Cha, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1377.
https://doi.org/10.1182/blood-2019-130500
Published: 2019
Journal Articles

Identification of Novel Therapeutic Targets in Atm-Deficient Lymphomas Using a Whole Genome CRISPR/CAS-9 Screen

Tatjana Stankovic, MD PhD, Nicholas Davies, PhD, Louise J Tee, Andrew D Beggs, Malcolm Taylor, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1504.
https://doi.org/10.1182/blood-2019-129974
Published: 2019
Journal Articles

Use of Machine Learning in 2074 Cases of Acute Myeloid Leukemia for Genetic Risk Profiling

Shaun Fleming, MBBS,, Cheng-Hong Tsai, MD MSc, Hartmut Döhner, MD, Konstanze Döhner, Elli Papaemmanuil, PhD, Hwei-Fang Tien, MD, PhD, John Reynolds, PhD, Andrew H. Wei, PhD FRACP, FRCPA, MBBS, Hsin-An Hou
Journal: Blood
Blood (2019) 134 (Supplement_1): 1392.
https://doi.org/10.1182/blood-2019-128243
Published: 2019
Journal Articles

Results of a Clinical Trial of H3B-8800, a Splicing Modulator, in Patients with Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML)

David P. Steensma, MD, Martin Wermke, MD, Virginia M. Klimek, MD, Peter L Greenberg, MD, Patricia Font, Rami S. Komrokji, MD, Jay Yang, MD, Andrew M. Brunner, MD, Hetty E. Carraway, MD MBA, Lionel Ades, MD PhD, Aref Al-Kali, MD, Juan Manuel Alonso Dominguez, MD PhD MSc, Ana Alonso, MD, Catherine C. Coombs, MD, H. Joachim Deeg, MD, William B. Donnellan, MD, James M. Foran, MD, Guillermo Garcia-Manero, MD, Michael B. Maris, MD, Malgorzata McMasters, MD, Jean-Baptiste Micol, MD, Jaime Perez De Oteyza, MD PhD, Felicitas Thol, MD, Eunice S. Wang, MD, Justin M. Watts, MD, Silvia Buonamici, PhD, Amy Kim, MSPh PhD, Vikram Gourineni, MS, PharmD, Alyssa J Marino, Nathalie Rioux, MSc, PhD, Joanne Schindler, MD, Sherri Smith, MS, Huilan Yao, PhD, Xiaobin Yuan, Kun Yu, PhD, Uwe Platzbecker
Journal: Blood
Blood (2019) 134 (Supplement_1): 673.
https://doi.org/10.1182/blood-2019-123854
Published: 2019
Journal Articles

Critical Requirement of U2AF1 in the Maintenance and Function of Hematopoietic Stem Cells

Avik Dutta, PhD, Yue Yang, PhD, Bao Le, Golam Mohi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1195.
https://doi.org/10.1182/blood-2019-132007
Published: 2019
Journal Articles

Interactome Analysis of APOBEC3B in Multiple Myeloma

Yasuhiro Kazuma, MD, Kotaro Shirakawa, MD PhD, Anamaria Daniela Sarca, MD, Yoshihito Horisawa, MD, Hirofumi Fukuda, MD, Hiroyuki Matsui, MD, Hiroyuki Yamazaki, MD, Tadahiko Matsumoto, MD, Fumiko Tanabe, Ryo Morishita, PhD, Shinji Ito, PhD, Akifumi Takaori-Kondo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1259.
https://doi.org/10.1182/blood-2019-126856
Published: 2019
Journal Articles

The Splicing Factor RBM17 Supports Leukemia Stem Cell Self-Renewal

Lina Liu, Ana Vujovic, Joshua Xu, Kristin Hope, PhD, Yu Lu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1238.
https://doi.org/10.1182/blood-2019-126287
Published: 2019
Journal Articles

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Thomas P Loughran, Jr., MD, Brian Barth, PhD MS, BS
Journal: Blood
Blood (2019) 134 (Supplement_1): 1245.
https://doi.org/10.1182/blood-2019-130964
Published: 2019
Journal Articles

Role of Ubiquitin E3 Ligase UBR5 in B-Cell Development and Lymphoma

Tyler Gilbreath, B.S., Samantha Swenson, PhD, Shannon M. Buckley, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2794.
https://doi.org/10.1182/blood-2019-128747
Published: 2019
Journal Articles

A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Justin M. Watts, MD, Terrence J Bradley, MD, Amber Thomassen, Andrew M. Brunner, MD, Mark D. Minden, MD PhD, Nikolaos Papadantonakis, MDPhDMSc, Sameem Abedin, MD, Amanda J Baines, Olena Barbash, PhD, Shelby Gorman, Brandon E Kremer, MD PhD, Gautam M. Borthakur, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2656.
https://doi.org/10.1182/blood-2019-130337
Published: 2019
Journal Articles

Epigenomic Determinants of Transcriptional Activity in ASXL1 -Mutant Chronic Myelomonocytic Leukemia

Moritz Binder, MDMPH, Alexandre Gaspar Maia, PhD, Ryan M. Carr, MD PhD, Christopher Pin, PhD, Kurt Berger, Bonnie Alver, PhD, Keith Robertson, PhD, David Marks, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2987.
https://doi.org/10.1182/blood-2019-123191
Published: 2019
Journal Articles

Hotspot U2AF1 Mutations Determine Missplicing Selectivity: Novel Mechanisms Altering Splicing Factors

Vera Adema, PhD, Courtney E Hershberger, BS, Wencke Walter, PhD, Cassandra M Kerr, MS, Stephan Hutter, PhD, Yasunobu Nagata, MD PhD, Hassan Awada, Sunisa Kongkiatkamon, Christina Snider, Milo Co, Manja Meggendorfer, PhD, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Francesc Sole, PhD, Richard A Padgett, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2985.
https://doi.org/10.1182/blood-2019-129367
Published: 2019
Journal Articles

Marrow Ring Sideroblasts Are Highly Predictive for TP53 Mutation in MDS with Excess Blasts

David M Swoboda, MD, Jung-Hoon Lee, MD, Onyee Chan, MD, Rami S. Komrokji, MD, Najla Al Ali, M.Sc, Eric Padron, MD, Alan F. List, MD, Mohammad O Hussaini, MD, Jinming Song, MD PhD, David A Sallman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4244.
https://doi.org/10.1182/blood-2019-124772
Published: 2019
Journal Articles

Genomic Profiling of a Phase III Clinical Trial of Interferon Versus Hydroxyurea in MPN Patients Reveals Mutation-Specific and Treatment-Specific Patterns of Response

Trine Alma Knudsen, MD, Vibe Skov, PhD, Lillian Werner, MS, William Duke, Christopher J. Gibson, MD, Anwesha Nag, PhD, Aaron R. Thorner, PhD, Bruce Wollison, MS, Dennis Lund Hansen, MD, Thomas Stauffer Larsen, MD PhD, Christina Ellervik, MD PhD, Daniel El Fassi, MD, Karin de Stricker, MD, Lukas Frans Ocias, MD, Mette Brabrand, Ole Weis Bjerrum, MD PhD, Ulrik Malthe Overgaard, MD, Mikael Frederiksen, MD, Thomas Kielsgaard Kristensen, Torben A Kruse, Mads Thomassen, PhD, Torben Mourits-Andersen, MD, Marianne Tang Severinsen, MD PhD, Jesper Stentoft, MD, Joern Starklint, Peter Møller, MD, Donna S Neuberg, ScD, Lasse Kjær, PhD, Hans Hasselbalch, MD, R. Coleman Lindsley, MD PhD, Ann Mullally, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4202.
https://doi.org/10.1182/blood-2019-126164
Published: 2019
Journal Articles

Probing Aberrant Splicing in a Novel Model of SF3B1-Mutant Myelodysplastic Syndromes

Courtnee Clough, Stephanie Busch, B.S., Joey Pangallo, B.S., Robert K. Bradley, PhD, Sergei Doulatov, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1706.
https://doi.org/10.1182/blood-2019-129176
Published: 2019
Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2979.
https://doi.org/10.1182/blood-2019-126346
Published: 2019