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Journal Articles

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Free
Brian Estevez, Sara Borst, Danuta Jarocha, Varun Sudunagunta, Michael Gonzalez, James Garifallou, Hakon Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy Speck, Deborah L. French, Paul Gadue, Mortimer Poncz
Journal: Blood
Blood (2021) 137 (19): 2662–2675.
https://doi.org/10.1182/blood.2020006389
Published: 2021
Includes: Supplemental data
Journal Articles

Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL

Free
Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Rogers, Madhu M. Ouseph, Monica Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Leili Niu, Tiffaney Vincent, Guangwu Guo, Julia Frede, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, David T. Teachey, Andrew A. Lane, Daniel J. DeAngelo, Jon C. Aster, Bradley E. Bernstein, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 137 (18): 2463–2480.
https://doi.org/10.1182/blood.2019004547
Published: 2021
Includes: Supplemental data
Journal Articles

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Free
Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan
Journal: Blood
Blood (2020) 136 (7): 845–856.
https://doi.org/10.1182/blood.2020004801
Published: 2020
Includes: Supplemental data
Journal Articles

Single Cell Transcriptomics Predicts Relapse in Infants with Acute Lymphoblastic Leukemia

Free
Tito Candelli, PhD, Pauline Schneider, Patricia Garrido Castro, PhD, Luke A Jones, PhD, Rob Pieters, MDPhDMSc, Thanasis Margaritis, PhD, Ronald W. Stam, PhD, Frank C.P. Holstege, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3951.
https://doi.org/10.1182/blood-2019-123052
Published: 2019
Journal Articles

Analysis of Deficiency of Adenosine Deaminase 2 Pathogenesis Based on Single Cell RNA Sequencing of Monocytes

Free
Naoki Watanabe, Shouguo Gao, PhD, Sachiko Kajigaya, Carrie Diamond, MD, Lemlem Alemu, BS, Amanda Ombrello, MD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2317.
https://doi.org/10.1182/blood-2019-123859
Published: 2019
Journal Articles

A Unique Crosstalk between Tumor Cells and Hematopoietic Stem Cells Reveals a Myeloid Differentiation Pattern Signature Contributing to Metastasis

Free
Ksenia Magidey, PhD, Ksenya Kveler, PhD, Rachelly Normand, PhD, Tongwu Zhang, PhD, Michael Timaner, PhD, Ziv Raviv, PhD, Brian James, PhD, Roi Gazit, PhD, Ze'ev Ronai, PhD, Shai Shen-Orr, PhD, Yuval Shaked, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2465.
https://doi.org/10.1182/blood-2019-128126
Published: 2019
Journal Articles

VISTA Is a Novel Regulator of Macrophage Biology

Free
Parth Shah, MD, Mohamed Eltanbouly, BSc, Nicole Smits, Aurelien Sarde, Randolph Noelle, Rodwell Mabaera, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2320.
https://doi.org/10.1182/blood-2019-131310
Published: 2019
Journal Articles

Transcriptomic Heterogeneity and Clonal Evolution Associated with Therapeutic Resistance in Mantle Cell Lymphoma Revealed By Single Cell RNA-Seq

Free
Changying Jiang, PhD, Shaojun Zhang, PhD, Yuanxin Wang, Rongjia Zhang, Yang Liu, MD, Joseph Mitchell McIntosh, Guangchun Han, PhD, Ruiping Wang, PhD, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Hun Ju Lee, Raphael E Steiner, MD, Jorge Enrique Romaguera, MD, Preetesh Jain, MBBS, MDDM, PhD, Krystle Nomie, PhD, Andy Futreal, PhD, Linghua Wang, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5217.
https://doi.org/10.1182/blood-2019-129134
Published: 2019
Journal Articles

Single-Cell Transcriptomic and Proteomic Diversity in Multiple Myeloma

Free
Reyka G Jayasinghe, PhD, Yige Wu, BS, Ying Zhu, PhD, Ruiyang Liu, BS, Mark A. Fiala, BS, Daniel R. Kohnen, MBA, Chia-Feng Tsai, PhD, Smrithi Mani, BS, Justin King, BS, Michael P. Rettig, PhD, Julie O'Neal, PhD, Tianjiao Wang, BA, Steven M. Foltz, BS, MS, Lijun Yao, MS, Hua Sun, PhD, Catrina Fronick, BS, Scott R. Goldsmith, MD, John F. DiPersio, MD PhD, Ravi Vij, MBBS, Liu Tao, BS, PhD, Li Ding, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5531.
https://doi.org/10.1182/blood-2019-131005
Published: 2019
Journal Articles

Nascent Transcript and Single Cell Rnaseq Analysis Defines the Mechanism of Action of the LSD1 Inhibitor INCB059872 in Myeloid Leukemia

Free
Gretchen Johnston, Haley E. Ramsey, PhDMSc, Kristy Stengel, PhD, Shilpa Sampathi, PhD, Pankaj Acharya, PhD, Maria Arrate, MSc, Matthew C. Stubbs, PhD, Timothy Burn, PhD, Scott Hiebert, PhD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2509.
https://doi.org/10.1182/blood-2019-130458
Published: 2019
Journal Articles

Single Cell Profiling of DNMT3A-Mutant Progenitors Reveals LY86 As a Novel Pre-Leukemia Marker and Potential Therapeutic Target

Free
Mira Jeong, PhD, Sangbae Kim, PhD, Yumei Li, PhD, Rui Chen, PhD, Premal Lulla, MBBS, Margaret Goodell, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2724.
https://doi.org/10.1182/blood-2019-123597
Published: 2019
Journal Articles

Transcriptome Based Projection of Single Cells to Uncover Development and Heterogeneity of Abnormal Hematopoietic Cells

Free
Parashar Dhapola, MSc, Mikael Sommarin, Mohamed Eldeeb, MSc, Amol Ugale, PhD, David Bryder, PhD, Göran Karlsson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2520.
https://doi.org/10.1182/blood-2019-130587
Published: 2019
Journal Articles

Development of a Novel Deep Transfer Learning Framework to Characterize Inter- and Intra-Tumor Heterogeneity in Myeloma Patients

Free
Travis S Johnson, MS, Christina Y Yu, BSc, Chuanpeng Dong, MS, Tongxin Wang, BS, Mohammad Issam Abu Zaid, MBBS, Rafat Abonour, MD, G. David Roodman, MD PhD, Yunlong Liu, PhD, Kun Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3075.
https://doi.org/10.1182/blood-2019-130452
Published: 2019
Journal Articles

T-Cell Clonal Expansion and Activation Associated with Durable Clinical Response to Dual BTK and CDK4/6 Inhibitor Therapy in Mantle Cell Lymphoma

Free
Christina Y. Lee, MD, Maurizio Di Liberto, PhD, Yang Hu, PhD, Xiangao Huang, PhD, Nancy L Bartlett, MD, Kami J. Maddocks, MD, John P. Leonard, MD, Nils-Petter Rudqvist, PhD, Lorenzo Galluzzi, PhD, Peter Martin, FRCPC, MD MS, Olivier Elemento, PhD, Selina Chen-Kiang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3973.
https://doi.org/10.1182/blood-2019-122322
Published: 2019
Journal Articles

Mutations and Copy Number Gains of the BCL2 Family Members Mediate Resistance to Venetoclax in Multiple Myeloma (MM) Patients

Free
Paola Neri, MD PhD, Ranjan Maity, PhD, Jean-Baptiste Alberge, Sarthak Sinha, BSc, Justin Donovan, Madison Kong, Fajer Hasan, Arzina Jaffer, Lawrence H. Boise, PhD, Nizar Bahlis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 572.
https://doi.org/10.1182/blood-2019-127593
Published: 2019
Journal Articles

The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)

Free
Sara Rodríguez, PhD, Noemi Puig, MD PhD, Katerina Gemenetzi, Ibai Goicoechea, PhD, Cirino Botta, MD, Andreas Agathangelidis, PhD, Rafael Valdés-Mas, Juan José Garcés, María Teresa Cedena, José J Pérez, Leire Burgos, Maria Jose Calasanz, PhD BSc, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Irene Aires, Idoia Rodriguez, Sarvide Sarai, Felipe Prosper, MD PhD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Juan-José Lahuerta, MD PhD, Laura Rosinol Dachs, Joan Bladé, MD, Maria-Victoria Mateos, Anastasia Hadzidimitriou, PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 509.
https://doi.org/10.1182/blood-2019-128049
Published: 2019
Journal Articles

A Comprehensive Analysis of Single-Cell Chromatin Accessibility and Gene Expression Identifies Intra-Tumor Heterogeneity and Molecular Treatment Responses in Relapsed/Refractory Multiple Myeloma

Free
Alexandra M Poos, PhD, Jan-Philipp Mallm, PhD, Stephan M Tirier, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Katharina Bauer, Anja Baumann, Lukas John, MD, Isabelle Lander, BSc, Jing Xu, PhD, Moritz Przybilla, BSc, Anja Kunze, PhD, Carsten Mueller-Tidow, MD, Benedikt Brors, PhD, Oliver Stegle, PhD, Hartmut Goldschmidt, MD, Karsten Rippe, PhD, Marc S Raab, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 575.
https://doi.org/10.1182/blood-2019-130051
Published: 2019
Journal Articles

Single Cell Transcriptome Analysis Reveals Disease-Defining T Cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Free
Tomohiro Aoki, MD PhD, Lauren C. Chong, MSc, Katsuyoshi Takata, MD PhD, Katy Milne, Monirath Hav, PhD, Anthony Colombo, MS, Elizabeth Chavez, BSc, Cg RT, Tomoko Miyata-Takata, Vivian Lam, Chanel Ghesquiere, Daniel Kos, Talia Goodyear, Allen W. Zhang, Xuehai Wang, PhD, Saeed Saberi, Jiarui W. Ding, Pedro Farinha, MD PhD, Andrew P. Weng, MD PhD, Kerry J Savage, BSc, MD MSc, David W. Scott, MBChB, PhD, Gerald Krystal, PhD, Brad H. Nelson, Anja Mottok, MD PhD, Akil Merchant, MD, Sohrab P Shah, Christian Steidl, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 547.
https://doi.org/10.1182/blood-2019-121584
Published: 2019
Journal Articles

Cxcl8 Expands Hematopoietic Stem and Progenitor Cells and Alters Their Interaction with the Endothelial Niche

Free
Donn L Calkins, BS, Jami L Shaffer, B.S., Emily M Teets, B.S., Alex M Belardo, Serine Avagyan, MD PhD, Leonard I Zon, MD, Bradley W Blaser, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 527.
https://doi.org/10.1182/blood-2019-126151
Published: 2019
Journal Articles

Alterations in Sphingomyelin Metabolism Influences Tissue Factor Procoagulant Activity and the Release of TF-Positive Microvesicles

Free
Jue Wang, PhD, Usha Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1103.
https://doi.org/10.1182/blood-2019-125933
Published: 2019