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Journal Articles

Archiving of Somatic Novel Mutations Using Whole-Exome Sequencing in Pakistani Myeloid Leukemic Patients

Abdul Rehman Khalil, MBBS, M.Phil, Arshi Naz, Ikramdin Ujjan, PhD MBBS, Tahir S. Shamsi, MBBS,FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 5167.
https://doi.org/10.1182/blood-2019-131688
Published: 2019
Journal Articles

Clonal and Single Cell Dynamics of Resistance to Graft-Versus-Leukemia (GvL) in Chronic Lymphocytic Leukemia (CLL)

Pavan Bachireddy, MD, Nikolaos Barkas, PhD, Sachet A Shukla, PhD, Samuel Freeman, Liudmila Elagina, PhD, Vinhkhang N Nguyen, Kendell Clement, PhD, Ignaty Leshchiner, PhD, Jennifer R. Brown, MD PhD, Donna S Neuberg, ScD, Vincent T. Ho, MD, Robert J. Soiffer, MD, Jerome Ritz, MD PhD, Gad Getz, PhD, Edwin P. Alyea, III, MD, Peter Kharchenko, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 820.
https://doi.org/10.1182/blood-2018-99-116681
Published: 2018
Journal Articles

Pharmacologic Inhibition of PI3Kδ Prolongs Survival of Mutant Shp2 E76K -Expressing Mice

Lisa Deng, Elizabeth L Virts, PhD, Rebecca J Chan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1240.
https://doi.org/10.1182/blood.V130.Suppl_1.1240.1240
Published: 2017
Journal Articles

Felipe Samaniego

Neeraj Jain, PhD, Lalit Sehgal, PhD, R. Eric Davis, MD, Stephen Joseph Shuttleworth, PhD, Felipe Samaniego, MD
Journal: Blood
Blood (2016) 128 (22): 5145.
https://doi.org/10.1182/blood.V128.22.5145.5145
Published: 2016
Journal Articles

Rituximab-Induced CD20-Mediated Signals and Suppression of PI3K-AKT Pathway Cooperates to Inhibit B-Cell Lymphoma Growth By Down-Regulation of Myc.

Tsuyoshi Nakamaki, MD, Yuta Baba, MD, Maasa Abe, MD, Sou Murai, MD, Megumi Watanuki, MD, Nobuyuki Kabasawa, MD, Kouji Yanagisawa, MD, Norimichi Hattori, MD, Yukiko Kawaguchi, MD, Nana Arai, MD, Shun Fujiwara, MD, Bungo Saito, MD
Journal: Blood
Blood (2016) 128 (22): 5312.
https://doi.org/10.1182/blood.V128.22.5312.5312
Published: 2016
Journal Articles

Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1 T315I mutant Cells

Renata Scopim-Ribeiro, M.Sc., João Agostinho Machado-Neto, PhD, Christopher A. Eide, Paula de Melo Campos, PhD, Priscila Santos Scheucher, PhD, Sara Teresinha Olalla Saad, MD PhD, Eduardo Magalhães Rego, MD, PhD, Cristina E. Tognon, Brian J. Druker, MD, Fabiola Traina, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 1886.
https://doi.org/10.1182/blood.V128.22.1886.1886
Published: 2016
Journal Articles

INPP4B is a Biomarker of Poor Prognosis in AML Which is Associated with EVI1 Overexpression and a LSC Signature

Irakli Dzneladze, BSc, John F Woolley, PhD, Youqi Han, PhD, Mark Sharobim, BSc, Ayesha Rashid, MSc, Michael D Jain, PhD MD, Mark D. Minden, MD PhD, Leonardo Salmena, PhD
Journal: Blood
Blood (2016) 128 (22): 3929.
https://doi.org/10.1182/blood.V128.22.3929.3929
Published: 2016
Journal Articles

Frequent Genetic Alterations of PI3K-AKT Pathway and Their Clinical Significance in Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma

Daisuke Ennishi, Ali Bashashati, Saeed Saberi, Anja Mottok, Barbara Meissner, Merrill Boyle, Susana Ben-Neriah, Robert Kridel, David Dominguez-Sola, MD PhD, Kerry J Savage, MD, Laurie H Sehn, MD, Joseph M. Connors, Ryan D. Morin, Marco A. Marra, PhD, Sohrab P. Shah, Christian Steidl, MD, David W. Scott, Randy D Gascoyne, MD
Journal: Blood
Blood (2016) 128 (22): 607.
https://doi.org/10.1182/blood.V128.22.607.607
Published: 2016
Journal Articles

PDK1 Controls the Differentiation of Hematopoietic Stem Cells Via Modulating ROS Levels

Tianyuan Hu, PhD, Cong Li, Le Wang, Yingchi Zhang, Luyun Peng, Weili Wang, Xiaomin Wang, Yajing Chu, Yingdai Gao, Bing Liu, Zhenyu Ju, Tao Cheng, MD, Weiping Yuan, PhDMD
Journal: Blood
Blood (2015) 126 (23): 896.
https://doi.org/10.1182/blood.V126.23.896.896
Published: 2015
Journal Articles

The Genomic Landscape of Childhood T-Lineage Acute Lymphoblastic Leukemia

Yu Liu, PhD, John Easton, PhD, Ying Shao, Mark Wilkinson, Michael Edmonson, PhD, Xiaotu Ma, PhD, Malcolm A. Smith, MD PhD, Michael Rusch, BA, Jaime Guidry Auvil, Daniela S. Gerhard, PhD, Mary V. Relling, PharmD, Naomi J. Winick, MD, Elizabeth Raetz, MD, Meenakshi Devidas, PhD, Cheryl L. Willman, MD, Richard C. Harvey, PhD, William L. Carroll, MD, Kimberly P. Dunsmore, MD, Stuart S. Winter, MD, Brent L Wood, MD PhD, James R. Downing, MD, Mignon L. Loh, MD, Stephen P Hunger, MD, Jinghui Zhang, PhD, Charles G. Mullighan, MBBS, MSc, MD
Journal: Blood
Blood (2015) 126 (23): 691.
https://doi.org/10.1182/blood.V126.23.691.691
Published: 2015
Journal Articles

PP2A Is Required for B Cell Survival and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

Xiao Gang, PhD, Huimin Geng, PhD, Lai N Chan, PhD, Zhengshan Chen, MDPhD, Xiaoyan Jiang, MDPhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 902.
https://doi.org/10.1182/blood.V126.23.902.902
Published: 2015
Journal Articles

IFITM3 (CD225) Links the B Cell Antigen CD19 to PI3K-AKT Signaling in Human ALL Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Eugene PARK, PhD, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1325.
https://doi.org/10.1182/blood.V126.23.1325.1325
Published: 2015
Journal Articles

T-Cell Acute Lymphoblastic Leukemia Patients with Mutations in IL7Ra or Downstream RAS-MEK or PI3K-AKT Can be Collectively Targeted By Combination of RAS and AKT Inhibitors

Kirsten Canté-Barrett, PhD, Jill AP Spijkers-Hagelstein, Jessica GCAM Buijs-Gladdines, Wilco K Smits, Rogier C Buijsman, PhD, Guido JR Zaman, PhD, Rob Pieters, MD PhD, Jules PP Meijerink, PhD
Journal: Blood
Blood (2015) 126 (23): 445.
https://doi.org/10.1182/blood.V126.23.445.445
Published: 2015
Journal Articles

Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling

Clinical Trials & Observations
Julie R. McMullen, Esther J. H. Boey, Jenny Y. Y. Ooi, John F. Seymour, Michael J. Keating, Constantine S. Tam
Journal: Blood
Blood (2014) 124 (25): 3829–3830.
https://doi.org/10.1182/blood-2014-10-604272
Published: 2014
Includes: Supplemental data
Journal Articles

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Christian Hurtz, PhD, Dirk Baumjohann, PhD, Zhengshan Chen, MD PhD, Wei-Yi Chen, PhD, Erica Ballabio, PhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Anne Deucher, MDPhD, Zhongxia Qi, PhD, Chuanxin Huang, PhD, Rahul Nahar, PhD, Soo-mi Kweon, PhD, Seyedmehdi Shojaee, PhD, Lai N Chan, PhD, Jingwei Yu, PhD, Jeffrey W. Tyner, PhD, Bill H Chang, MD PhD, Steven M. Kornblau, MD, Janetta Jacoba Bijl, PhD, B. Hilda Ye, PhD, Elisabeth Paietta, PhD, Ari Melnick, MD, Robert Roeder, PhD, Stephen Hunger, MD, Mignon Loh, MD, Thomas Milne, PhD, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 284.
https://doi.org/10.1182/blood.V124.21.284.284
Published: 2014
Journal Articles

Improved Hematopoietic Differentiation of Primate Embryonic Stem Cells

Takenobu Nii, PhD, Tomotoshi Marumoto, MD PhD, Saori Yamaguchi, Hirotaka Kawano, Yoshie Kametani, PhD, Kenzaburo Tani, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2918.
https://doi.org/10.1182/blood.V124.21.2918.2918
Published: 2014
Journal Articles

Chronic Myeloid Leukemia Stem Cells (LSCs) and Leukemia Progenitor Cells (LPCs) Display Overlapping and Unique Mechanisms of Genomic Instability: The Role of PI3k-AKT and PI3k-Rac2-PAK Pathways

Margaret Nieborowska-Skorska, MD PhD, Sylwia Flis, PhD, Tomasz Skorski, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1791.
https://doi.org/10.1182/blood.V124.21.1791.1791
Published: 2014
Journal Articles

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells

Seyedmehdi Shojaee, PhD, Valeria Cazzaniga, Hilde Schjerven, PhD, Maike Buchner, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Andreas Hochhaus, MD, Giovanni Cazzaniga, PhD, Ari M Melnick, MD, Steven M. Kornblau, MD, Thomas G Graeber, PhD, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 262.
https://doi.org/10.1182/blood.V124.21.262.262
Published: 2014
Journal Articles

Oncogenic Insult In Bone Marrow Endothelial Cells Causes Hematopoietic Abnormalities

Yuxin Feng, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2013) 122 (21): 2461.
https://doi.org/10.1182/blood.V122.21.2461.2461
Published: 2013
Journal Articles

Classification Of Acute Myelogenous Leukemia (AML) Based On Functionally Related Proteins Groups

Steven M. Kornblau, MD, Chenyu W Hu, Suk Young Yoo, PhD, Yihua Qiu, MD, Nianxiang Zhang, PhD, Gautam Borthakur, MD, Naval G. Daver, MD, Amina A Qutub, PhD, Kevin R. Coombes, PhD
Journal: Blood
Blood (2013) 122 (21): 492.
https://doi.org/10.1182/blood.V122.21.492.492
Published: 2013