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Journal Articles

Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models

Free
Andrea Iannello, Nicoletta Vitale, Silvia Coma, Francesca Arruga, Amy Chadburn, Arianna Di Napoli, Carlo Laudanna, John N. Allan, Richard R. Furman, Jonathan A. Pachter, Silvia Deaglio, Tiziana Vaisitti
Journal: Blood
Blood (2021) 137 (24): 3378–3389.
https://doi.org/10.1182/blood.2020010187
Published: 2021
Includes: Supplemental data
Journal Articles

Molecular determinants of the factor VIII/von Willebrand factor complex revealed by BIVV001 cryo-electron microscopy

Free
James R. Fuller, Kevin E. Knockenhauer, Nina C. Leksa, Robert T. Peters, Joseph D. Batchelor
Journal: Blood
Blood (2021) 137 (21): 2970–2980.
https://doi.org/10.1182/blood.2020009197
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

TLR8 gain of function: a tall surprise

Free
Bertrand Boisson, Jean-Laurent Casanova
Journal: Blood
Blood (2021) 137 (18): 2420–2422.
https://doi.org/10.1182/blood.2020010463
Published: 2021
Journal Articles

Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL

Free
Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Rogers, Madhu M. Ouseph, Monica Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Leili Niu, Tiffaney Vincent, Guangwu Guo, Julia Frede, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, David T. Teachey, Andrew A. Lane, Daniel J. DeAngelo, Jon C. Aster, Bradley E. Bernstein, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 137 (18): 2463–2480.
https://doi.org/10.1182/blood.2019004547
Published: 2021
Includes: Supplemental data
Journal Articles

Requirement for antiapoptotic MCL-1 during early erythropoiesis

Free
Meghan E. Turnis, Ewa Kaminska, Kaitlyn H. Smith, Brittany J. Kartchner, Peter Vogel, Jonathan D. Laxton, Richard A. Ashmun, Paul A. Ney, Joseph T. Opferman
Journal: Blood
Blood (2021) 137 (14): 1945–1958.
https://doi.org/10.1182/blood.2020006916
Published: 2021
Includes: Supplemental data
Journal Articles

Rapid single-molecule digital detection of protein biomarkers for continuous monitoring of systemic immune disorders

Free
Yujing Song, Erin Sandford, Yuzi Tian, Qingtian Yin, Andrew G. Kozminski, Shiuan-Haur Su, Tao Cai, Yuxuan Ye, Meng Ting Chung, Ryan Lindstrom, Annika Goicochea, Jenny Barabas, Mary Olesnavich, Michelle Rozwadowski, Yongqing Li, Hasan B. Alam, Benjamin H. Singer, Monalisa Ghosh, Sung Won Choi, Muneesh Tewari, Katsuo Kurabayashi
Journal: Blood
Blood (2021) 137 (12): 1591–1602.
https://doi.org/10.1182/blood.2019004399
Published: 2021
Includes: Supplemental data
Journal Articles

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy

Free
Semjon Willier, Paula Rothämel, Maximilian Hastreiter, Jonas Wilhelm, Dana Stenger, Franziska Blaeschke, Meino Rohlfs, Theresa Kaeuferle, Irene Schmid, Michael H. Albert, Vera Binder, Marion Subklewe, Christoph Klein, Tobias Feuchtinger
Journal: Blood
Blood (2021) 137 (8): 1037–1049.
https://doi.org/10.1182/blood.2020006921
Published: 2021
Includes: Supplemental data
Journal Articles

The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells

Free
Lijian Shao, Adedamola Elujoba-Bridenstine, Katherine E. Zink, Laura M. Sanchez, Brian J. Cox, Karen E. Pollok, Anthony L. Sinn, Barbara J. Bailey, Emily C. Sims, Scott H. Cooper, Hal E. Broxmeyer, Kostandin V. Pajcini, Owen J. Tamplin
Journal: Blood
Blood (2021) 137 (6): 775–787.
https://doi.org/10.1182/blood.2019004415
Published: 2021
Includes: Supplemental data
Journal Articles

DARTs point the way forward in AML

Free
Clinical Trials & Observations
Saar Gill
Journal: Blood
Blood (2021) 137 (6): 720–721.
https://doi.org/10.1182/blood.2020009020
Published: 2021
Journal Articles

Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia

Free
Clinical Trials & Observations
Geoffrey L. Uy, Ibrahim Aldoss, Matthew C. Foster, Peter H. Sayre, Matthew J. Wieduwilt, Anjali S. Advani, John E. Godwin, Martha L. Arellano, Kendra L. Sweet, Ashkan Emadi, Farhad Ravandi, Harry P. Erba, Michael Byrne, Laura Michaelis, Max S. Topp, Norbert Vey, Fabio Ciceri, Matteo Giovanni Carrabba, Stefania Paolini, Gerwin A. Huls, Mojca Jongen-Lavrencic, Martin Wermke, Patrice Chevallier, Emmanuel Gyan, Christian Récher, Patrick J. Stiff, Kristen M. Pettit, Bob Löwenberg, Sarah E. Church, Erica Anderson, Jayakumar Vadakekolathu, Marianne Santaguida, Michael P. Rettig, John Muth, Teia Curtis, Erin Fehr, Kuo Guo, Jian Zhao, Ouiam Bakkacha, Kenneth Jacobs, Kathy Tran, Patrick Kaminker, Maya Kostova, Ezio Bonvini, Roland B. Walter, Jan K. Davidson-Moncada, Sergio Rutella, John F. DiPersio
Journal: Blood
Blood (2021) 137 (6): 751–762.
https://doi.org/10.1182/blood.2020007732
Published: 2021
Includes: Supplemental data
Journal Articles

Cytokines and costimulation in acute graft-versus-host disease

Free
Geoffrey R. Hill, Motoko Koyama
Journal: Blood
Blood (2020) 136 (4): 418–428.
https://doi.org/10.1182/blood.2019000952
Published: 2020
Journal Articles

HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR

Free
Kazuya Sakai, Masataka Kuwana, Hidenori Tanaka, Kazuyoshi Hosomichi, Atsushi Hasegawa, Hiroki Uyama, Kenji Nishio, Takashi Omae, Masakatsu Hishizawa, Masashi Matsui, Koji Iwato, Akinao Okamoto, Kazuki Okuhiro, Yukiko Yamashita, Masataka Itoh, Hanae Kumekawa, Naoki Takezako, Noriaki Kawano, Toshihiro Matsukawa, Haruna Sano, Kazuiku Ohshiro, Kunio Hayashi, Yasunori Ueda, Toshiki Mushino, Yoshiyuki Ogawa, Yuji Yamada, Mitsuru Murata, Masanori Matsumoto
Journal: Blood
Blood (2020) 135 (26): 2413–2419.
https://doi.org/10.1182/blood.2020005395
Published: 2020
Includes: Supplemental data
Journal Articles

A master erythroid regulator gets its own GPS

Free
Lily Jun-shen Huang, James J. Bieker
Journal: Blood
Blood (2020) 135 (25): 2209–2210.
https://doi.org/10.1182/blood.2020005882
Published: 2020
Journal Articles

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Free
Lanzhu Yue, Vasundhara Sharma, Nathan P. Horvat, Afua A. Akuffo, Matthew S. Beatty, Cem Murdun, Christelle Colin, Julia M. R. Billington, William E. Goodheart, Eva Sahakian, Ling Zhang, John J. Powers, Narmin E. Amin, Que T. Lambert-Showers, Lancia N. Darville, Javier Pinilla-Ibarz, Gary W. Reuther, Kenneth L. Wright, Chiara Conti, Jennifer Y. Lee, Xiaozhang Zheng, Pui Yee Ng, Matthew W. Martin, C. Gary Marshall, John M. Koomen, Ross L. Levine, Amit Verma, H. Leighton Grimes, Eduardo M. Sotomayor, Zonghong Shao, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2020) 135 (3): 191–207.
https://doi.org/10.1182/blood.2019895326
Published: 2020
Includes: Supplemental data
Journal Articles

FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

Free
Chiawei Chang, Sjoukje Van Der Stegen, PhD, Mandal Mili, PhD, Raedun Clarke, PhD, Yi-Shin Lai, PhD, Alec Witty, PhD, Pieter Lindenbergh, Bi-Huei Yang, PhD, Mushtaq Husain, PhD, Helena Shaked, PhD, Brian Groff, Laurel Stokely, Ramzey Abujarour, PhD, Tom Lee, PhD, Hui-Yi Chu, PhD, Mochtar Pribadi, PhD, Jason ORourke, PhD, Alma Gutierrez, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4434.
https://doi.org/10.1182/blood-2019-130584
Published: 2019
Journal Articles

Preclinical Characterization of an ANTI-CD38/CD3 T CELL-Redirecting Bispecific Antibody

Free
Xiao He, PhD, Yanliang Zhang, PhD, Yun Wei Lai, MSc, Stephanie Baguley, MSc, Yan Li, PhD, Xia Cao, MSc, Ying Yan, PhD, Ken Takeshita, MD, Jerome B. Zeldis, MD PhD, Henry Ji, PhD, Gunnar F. Kaufmann, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4463.
https://doi.org/10.1182/blood-2019-131540
Published: 2019
Journal Articles

CYT-0853, a Novel RAD51 Inhibitor, Modulates Immunoregulatory B-Lymphocytes

Free
Tamar Aprahamian, PhD, ED Keniston, Jane Branca, Muneer G Hasham, PhD, Melinda Day, PhD, Kevin Mills, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2330.
https://doi.org/10.1182/blood-2019-131311
Published: 2019
Journal Articles

Characterization of Clonal Dynamics after Hematopoietic Cell Transplantation Using Ultra-Sensitive Duplex Sequencing

Free
Jacob Higgins, PhD, Gabriel Pratt, PhD, Charles C. Valentine, MS, Lindsey N. Williams, PhD, Masumi Ueda, MD, Rainer Storb, MD, Jerald P. Radich, MD, Jesse J. Salk, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2483.
https://doi.org/10.1182/blood-2019-122490
Published: 2019
Journal Articles

Gpibα Engagement Induces Activation of Human Platelet TF and Association with Constitutively Platelet Surface-Bound FVIIa

Free
Olga Panes, Biochemist, M. Francisca Becerra, Biochemist, Roger Valle, Biochemist, Claudia G Sáez, PhD, Patricia Hidalgo, MT, Jaime Pereira, MD, Jennifer Royce, Wolfram Ruf, MD, PhD, Diego Mezzano, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2337.
https://doi.org/10.1182/blood-2019-126359
Published: 2019
Journal Articles

iPLA2β Contributes to Activation of Human and Mouse Platelets Via ITAM Receptors Fcγ RIIA and GPVI

Free
Shaji Abraham, PhD, Pravin Patel, BA, Ulhas P. Naik, PhD, Steven Edward McKenzie, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2339.
https://doi.org/10.1182/blood-2019-128426
Published: 2019