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Journal Articles

Intrinsic and Extrinsic Factors Driving Hematopoietic Stem Cell Aging and Bone Marrow Failure

Jennifer J. Trowbridge, PhD

Blood (2019) 134 (Supplement_1): SCI-35.

https://doi.org/10.1182/blood-2019-121044

Published: 2019

Journal Articles

Pivotal Role of OCL-Derived IGF1 in Drug Resistance and Bone Destruction in MM

Jumpei Teramachi, Kazuaki Miyagawa, DDS, PhD, Delgado-Calle Jesus, PhD, Jolene Windle, PhD, Noriyoshi Kurihara, DDS, PhD, G David Roodman, MD PhD

Blood (2019) 134 (Supplement_1): 4336.

https://doi.org/10.1182/blood-2019-126959

Published: 2019

Journal Articles

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Virginia Campos Silvestrini, BSc, MSc, Eduardo M Rego, MD PhD, Vitor Marcel Faca, PhD, João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 2689.

https://doi.org/10.1182/blood-2019-132129

Published: 2019

Journal Articles

Inducible SBDS Deficiency Impairs Bone Marrow Niche Function to Engraft Donor Hematopoietic Stem Cell after Transplantation

Ji Zha, PhD BS, Lori Kunselman, Hongbo Michael Xie, PhD, Brian Ennis, Jian-Meng Fan, Timothy S. Olson, MD PhD

Blood (2019) 134 (Supplement_1): 3199.

https://doi.org/10.1182/blood-2019-121763

Published: 2019

Journal Articles

The mTOR Component, Rictor, Is Regulated By the Microenvironment to Control Dormancy and Proliferative States in Myeloma Cells

Syed J. Mehdi, PhD, Sarah K Johnson, PhD, Tarun K. Garg, PhD, Cody Ashby, PhD, Maurizio Zangari, MD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Joshua Epstein, DSc, Brian A Walker, PhD, Frits van Rhee, MD PhD, Shmuel Yaccoby, PhD

Blood (2019) 134 (Supplement_1): 4412.

https://doi.org/10.1182/blood-2019-127382

Published: 2019

Journal Articles

Targeting Sirt6 with OSS_128167 Displays Anti-Tumor Activities in Diffuse Large B-Cell Lymphoma through Down-Regulation of PI3K Signaling

Juan Yang, MM, Xiangxiang Zhou, MD, Ying Li, MD, Ya Zhang, MD, Xiaosheng Fang, MD, Na Chen, MD, Xin Wang, MD PhD

Blood (2019) 134 (Supplement_1): 5065.

https://doi.org/10.1182/blood-2019-127926

Published: 2019

Journal Articles

Clonal Hematopoiesis and Genetic Mutations in Individual Patients with Acquired Bone Marrow Failure Diseases

Baixin Ye, Xinhua Du, Li Yan, Qingping Gao, Chunrui Li, MD PhD, Jianfeng Zhou, Xin Yi, Fankai Meng

Blood (2019) 134 (Supplement_1): 937.

https://doi.org/10.1182/blood-2019-125357

Published: 2019

Journal Articles

Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway

Alireza Paikari, MD, Yankai Zhang, PhD, Alicia Chang, MD, Ankush Goyal, MA, Evadnie Rampersaud, PhD, Jonathan M. Flanagan, PhD, Mitchell J. Weiss, MD, PhD, Vivien A. Sheehan, MD PhD

Blood (2019) 134 (Supplement_1): 811.

https://doi.org/10.1182/blood-2019-131313

Published: 2019

Journal Articles

Decline in Insulin-like Growth Factor-1 (IGF1) from Aged Mesenchymal Stromal Cells Is a Targetable Mechanism to Rescue Hematopoietic Stem Cell Aging

Kira Young, PhD, Elizabeth Eudy, BS, Matthew Loberg, BA, Rebecca Bell, BA, Jennifer Trowbridge, PhD

Blood (2019) 134 (Supplement_1): 526.

https://doi.org/10.1182/blood-2019-124534

Published: 2019

Journal Articles

Seven Cases of JAK2 Mutation Negative Chronic Polycythemia Patients with Elevated IGF-1R

Guanfang Shi, PhD, Rewais Morcus, MD, Maksim Liaukovich, MD, Ching Wong, MD, Vladimir Gotlieb, Jen-Chin Wang, MD

Blood (2019) 134 (Supplement_1): 5389.

https://doi.org/10.1182/blood-2019-123006

Published: 2019

Journal Articles

The Role of Hypoxia on ABL Tyrosine Kinase Inhibitor Resistant Chronic Myeloid Leukemia Cells

Seiichi Okabe, MD PhD, Yuko Tanaka, MD PhD, Mitsuru Moriyama, Akihiko Gotoh, MD PhD

Blood (2019) 134 (Supplement_1): 5369.

https://doi.org/10.1182/blood-2019-129768

Published: 2019

Journal Articles

Insulin-like Growth Factor-1-Induced Epithelial-Mesenchymal Transition Promotes Multiple Myeloma Progression

Yue Peng, Xiaman Wang, Ying Shen, MD, Fangmei Li, PhD, Ru Zhang, MD, Yachun Jia, Aili He

Blood (2019) 134 (Supplement_1): 5541.

https://doi.org/10.1182/blood-2019-127714

Published: 2019

Journal Articles

Immunosuppressive Diversity of Umbilical Cord-Derived Mesenchymal Stromal Cells

Tokiko Nagamura-Inoue, MD PhD, Atsuko Takahashi, MT., Yuki Yamamoto, MT, Akiko Hori, Yuta Miharu, MT, Kazuo Ogami, MT, Miwako Narita, MD PhD, Fumitaka Nagamura, MD PhD, Arinobu Tojo, MD PhD

Blood (2019) 134 (Supplement_1): 3584.

https://doi.org/10.1182/blood-2019-128627

Published: 2019

Journal Articles

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Mykel D Green, Mitchell Schaffler, PhD, Gilda A Barabino, PhD

Blood (2019) 134 (Supplement_1): 3561.

https://doi.org/10.1182/blood-2019-128950

Published: 2019

Journal Articles

Transcriptional and Spatial Heterogeneity of Mouse Megakaryocytes at Single-Cell Resolution

Shu Sun, BS, Chen Jin, PhD, Yueying Li, MD, Jia Si, Yueli Cui, Matthew T. Rondina, MD, Fuchou Tang, PhD, Qian-fei Wang, PhD

Blood (2019) 134 (Supplement_1): 275.

https://doi.org/10.1182/blood-2019-129471

Published: 2019

Journal Articles

The Middle-Aged Bone Marrow Microenvironment Drives Hematopoietic Stem Cell Aging through Altered Production of Insulin-like Growth Factor-1 (IGF1)

Kira Young, PhD, Matthew Loberg, BA, Elizabeth Eudy, BS, Rebecca Bell, BA, Jennifer J. Trowbridge, PhD

Blood (2018) 132 (Supplement 1): 5091.

https://doi.org/10.1182/blood-2018-99-111055

Published: 2018

Journal Articles

Single Cell Analysis of Acquired Pomalidomide-Resistance in Multiple Myeloma Cell Lines Reveals Distinct Subclonal Cereblon Mutations and Gene Expression Heterogeneity

Sarah Gooding, Chad C. Bjorklund, Michael Amatangelo, Yan Ren, Mathieu Marella, Suzana Couto, Christopher Park, Sneh Lata, Reshma Nibhani, Fadi Towfic, PhD, Udo Oppermann, Karthik Ramasamy, William E. Pierceall, Paresh Vyas, Anjan Thakurta, PhD

Blood (2018) 132 (Supplement 1): 2648.

https://doi.org/10.1182/blood-2018-99-112644

Published: 2018

Journal Articles

Mesenchymal Stem Cells Gene Signature in High-Risk Myeloma Bone Marrow Linked to Suppression of Distinct IGFBP2-Expressing Small Adipocytes

Syed J. Mehdi, PhD, Sarah K Johnson, PhD, Joshua Epstein, DSc, Maurizio Zangari, MD, Pingping Qu, Antje Hoering, PhD, Frits van Rhee, MD PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Faith E. Davies, MD, Gareth Morgan, MD, Shmuel Yaccoby, PhD

Blood (2018) 132 (Supplement 1): 4448.

https://doi.org/10.1182/blood-2018-99-115244

Published: 2018

Journal Articles

FOXM1 and the NPM-ALK/STAT3 Axis Form a Novel Positive Feedback Loop in Promoting the Oncogenesis of ALK-Positive Anaplastic Large Cell Lymphoma

Peng Wang, MD PhD, Moinul Haque, Jing Li, Yung-Hsing Huang, Meaad Almowaled, Carter Bargar, Adam Karpf, Will Chen, Suzanne Turner, Raymond Lai, PhD MD

Blood (2018) 132 (Supplement 1): 3921.

https://doi.org/10.1182/blood-2018-99-115743

Published: 2018

Journal Articles

Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells

Noortje Van Gils, MSc, Han J.M.P. Verhagen, MSc, Arjo Rutten, Renee X. Menezes, Mei-Ling Tsui, Esmee Dekens, Fedor Denkers, E Vermue, Jeroen J. W. M. Janssen, MD PhD, Gert J. Ossenkoppele, MD PhD, Linda Smit, PhD

Blood (2018) 132 (Supplement 1): 3937.

https://doi.org/10.1182/blood-2018-99-115858

Published: 2018

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Intrinsic and Extrinsic Factors Driving Hematopoietic Stem Cell Aging and Bone Marrow Failure

Pivotal Role of OCL-Derived IGF1 in Drug Resistance and Bone Destruction in MM

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Inducible SBDS Deficiency Impairs Bone Marrow Niche Function to Engraft Donor Hematopoietic Stem Cell after Transplantation

The mTOR Component, Rictor, Is Regulated By the Microenvironment to Control Dormancy and Proliferative States in Myeloma Cells

Targeting Sirt6 with OSS_128167 Displays Anti-Tumor Activities in Diffuse Large B-Cell Lymphoma through Down-Regulation of PI3K Signaling

Clonal Hematopoiesis and Genetic Mutations in Individual Patients with Acquired Bone Marrow Failure Diseases

Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway

Decline in Insulin-like Growth Factor-1 (IGF1) from Aged Mesenchymal Stromal Cells Is a Targetable Mechanism to Rescue Hematopoietic Stem Cell Aging

Seven Cases of JAK2 Mutation Negative Chronic Polycythemia Patients with Elevated IGF-1R

The Role of Hypoxia on ABL Tyrosine Kinase Inhibitor Resistant Chronic Myeloid Leukemia Cells

Insulin-like Growth Factor-1-Induced Epithelial-Mesenchymal Transition Promotes Multiple Myeloma Progression

Immunosuppressive Diversity of Umbilical Cord-Derived Mesenchymal Stromal Cells

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Transcriptional and Spatial Heterogeneity of Mouse Megakaryocytes at Single-Cell Resolution

The Middle-Aged Bone Marrow Microenvironment Drives Hematopoietic Stem Cell Aging through Altered Production of Insulin-like Growth Factor-1 (IGF1)

Single Cell Analysis of Acquired Pomalidomide-Resistance in Multiple Myeloma Cell Lines Reveals Distinct Subclonal Cereblon Mutations and Gene Expression Heterogeneity

Mesenchymal Stem Cells Gene Signature in High-Risk Myeloma Bone Marrow Linked to Suppression of Distinct IGFBP2-Expressing Small Adipocytes

FOXM1 and the NPM-ALK/STAT3 Axis Form a Novel Positive Feedback Loop in Promoting the Oncogenesis of ALK-Positive Anaplastic Large Cell Lymphoma

Insulin-like Growth Factor Binding Protein 7 Activates the Retinoid Acid Differentiation Pathway in Acute Myeloid Leukemia Cells

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