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Journal Articles

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Eric R. Henry, Belhu Metaferia, Quan Li, Julia Harper, Robert B. Best, Kristen E. Glass, Troy Cellmer, Emily B. Dunkelberger, Anna Conrey, Swee Lay Thein, H. Franklin Bunn, William A. Eaton

Blood (2021) 138 (13): 1172–1181.

https://doi.org/10.1182/blood.2021012070

Published: 2021

Includes: Supplemental data

Journal Articles

Sickle marrow: double, double toil and trouble

Mark C. Walters

Blood (2020) 135 (23): 2017–2018.

https://doi.org/10.1182/blood.2020005114

Published: 2020

Journal Articles

Fetal Hemoglobin Promotes P. Falciparum Growth in Sickle Cell Disease Erythrocytes

Natasha M. Archer, MD, Manoj Duraisingh

Blood (2019) 134 (Supplement_1): 2252.

https://doi.org/10.1182/blood-2019-130763

Published: 2019

Journal Articles

Profound Alteration of Host Response in Severe Malarial Anemia By Sickle Cell Disease: Reduction of Parasite Sequestration and Inflammation, Upregulation of Angiopoietin-2

Ryan C Henrici, PhD BS, Casey Sautter, MDMS, Robert Opoka, MMED, Ruth Namazzi, MD, Gregory S Park, Dibyadyuti John, PhD, Andrea L Conroy, PhD, Russell E. Ware, MD PhD, Chandy C. John, MDMS

Blood (2019) 134 (Supplement_1): 2283.

https://doi.org/10.1182/blood-2019-129566

Published: 2019

Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD

Blood (2019) 134 (Supplement_1): 2260.

https://doi.org/10.1182/blood-2019-128727

Published: 2019

Journal Articles

Crizanlizumab Treatment Is Associated with Clinically Significant Reductions in Hospitalization in Patients with Sickle Cell Disease: Results from the Sustain Study

Kenneth I. Ataga, MD, Abdullah Kutlar, MD, Laurie DeBonnett, MD, Jeremie Lincy, Julie Kanter, MD

Blood (2019) 134 (Supplement_1): 2289.

https://doi.org/10.1182/blood-2019-125868

Published: 2019

Journal Articles

Iron Restriction Improves Markers of Disease Severity in the Townes Mouse Model of Sickle Cell Anemia

Nermi Parrow, PhD, Pierre-Christian Violet, PhD, Nisha George, PhD, Faris Ali, Shivam Bhanvadia, Mark Levine, MD, Robert E Fleming, MD

Blood (2019) 134 (Supplement_1): 2261.

https://doi.org/10.1182/blood-2019-130732

Published: 2019

Journal Articles

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

Satheesh Chonat, MD, Earl Fields, Hannah Baratz, Amanda Watt, Mira Pochron, PhD, Sandy Dixon, Margaret Tonda, PharmD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Clark Brown, MD PhD, David R. Archer, PhD

Blood (2019) 134 (Supplement_1): 2281.

https://doi.org/10.1182/blood-2019-129351

Published: 2019

Journal Articles

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Blood (2019) 134 (Supplement_1): 2244.

https://doi.org/10.1182/blood-2019-127017

Published: 2019

Journal Articles

The Oxygenscan Provides Clinically Relevant Biomarkers for Treatment Efficacy That Are Associated with Frequency of Vaso-Occlusive Crisis in Sickle Cell Disease

Minke A.E. Rab, MD, Richard van Wijk, PhD, Celeste K. Kanne, BA, Brigitte A. van Oirschot, Jennifer Bos, Camille Boisson, Maite E. Houwing, MD, Jorn J. Gerritsma, MD, Karin Fijnvandraat, MD PhD, Celine Renoux, PhD, Marije Bartels, MD PhD, Erfan Nur, MD PhD, Marjon H. Cnossen, MD PhD, Philippe Joly, PhD, Romain Fort, MD, Philippe Connes, PhD, Eduard J. van Beers, MD PhD, Vivien A. Sheehan, MD PhD

Blood (2019) 134 (Supplement_1): 2275.

https://doi.org/10.1182/blood-2019-128870

Published: 2019

Journal Articles

Unusually High Prevalence of Silent Stroke and Cerebral Vasculopathy in Hemoglobin SC Disease

Bindu K Sathi, MD, Yoshida Yilin, PhD, Michael Raymond Weaver, BA, Lila Wahidi Nolan, MD, Barbara Gruner, MD, Cara Hirner, RN, BSN, Vinod V. Balasa, MBBS, Talissa Altes, MD, Carlos Leiva Salinas, MD

Blood (2019) 134 (Supplement_1): 2276.

https://doi.org/10.1182/blood-2019-122975

Published: 2019

Journal Articles

Benefit and Safety of Isovolemic Hemodilution Prior to Red Cell Exchange in Chronically Transfused Sickle Cell Patients

Katayoun Fomani, MD, Cindy Xu, Swathi Ratkal, MD, Vijay Nandi, PhD, Abena Appiah-Kubi, MD MPH, Banu Aygun, MD, James Louie, MD, Patricia Shi, MD

Blood (2019) 134 (Supplement_1): 2291.

https://doi.org/10.1182/blood-2019-122259

Published: 2019

Journal Articles

Cannabidiol Reduces Acute and Chronic Hyperalgesia in Humanized Sickle Mice

Varun Sagi, BS, Jianxun Lei, PhD, Stacy B Kiven, BS, Huy Tran, BS, Kalpna Gupta, PhD

Blood (2019) 134 (Supplement_1): 77.

https://doi.org/10.1182/blood-2019-129706

Published: 2019

Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM

Blood (2019) 134 (Supplement_1): 73.

https://doi.org/10.1182/blood-2019-128646

Published: 2019

Journal Articles

Implementation of a Standard Order Set at a Sickle Cell Acute Care Observation Unit

Renee Cheng, MD, Rishi Patel, MD, Sandra Kang, MD, Frances Tian, MD, Xu Zhang, PhD, Jin Han, PharmD, PhD, Jayleen Patel, MD, Netanel Zilberstein, MD, Victor R Gordeuk, MD, Michel Gowhari, DO

Blood (2019) 134 (Supplement_1): 3396.

https://doi.org/10.1182/blood-2019-130877

Published: 2019

Journal Articles

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

Theodosia A. Kalfa, MD PhD, Frans A Kuypers, PhD, Marilyn J. Telen, MD, Punam Malik, MD, Diamantis G. Konstantinidis, PhD BSc, Jeremy H. Estepp, MD, Hyon J. Kim, MD PhD, Santosh L. Saraf, MD, Lindsey Wilson, Maria D Ribadeneira, PhD, Sanjeev Forsyth, Patricia Schroeder, Adam Drake, Olga Polyanskaya, Patrick Kelly, MD, Lukasz Biernat, MD

Blood (2019) 134 (Supplement_1): 616.

https://doi.org/10.1182/blood-2019-121889

Published: 2019

Journal Articles

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

Blood (2019) 134 (Supplement_1): 615.

https://doi.org/10.1182/blood-2019-123355

Published: 2019

Journal Articles

Unswitched Memory B Cell Deficiency Is Associated with Acute Chest Syndrome and Stroke in Sickle Cell Disease

Sameera Bhamidipati, MA, Venee N. Tubman, MD, Norma Estrada, Charles Minard, PhD

Blood (2019) 134 (Supplement_1): 1010.

https://doi.org/10.1182/blood-2019-128575

Published: 2019

Journal Articles

The Effect of Crizanlizumab Plus Standard of Care (SoC) Versus Soc Alone on Renal Function in Patients with Sickle Cell Disease and Chronic Kidney Disease: A Randomized, Multicenter, Open-Label, Phase II Study (STEADFAST)

Kenneth I. Ataga, MD, Santosh L. Saraf, MD, Vimal K. Derebail, MD, Claire C. Sharpe, Adlette Inati, MD, Jeffrey D. Lebensburger, DO, MSPH, Laurie DeBonnett, MD, Shirong Zhang, Pablo Bartolucci, MD PhD

Blood (2019) 134 (Supplement_1): 1018.

https://doi.org/10.1182/blood-2019-124823

Published: 2019

Journal Articles

Complications of Extra Fluid Therapy (Hyperhydration) in Sickle Cell Patients during Vaso-Occlusive Painful Crisis

Aafke E. Gaartman, MD, Ajab K. Sayedi, BSc, Charlotte F.J. Van Tuijn, MPH, PhD, Harriet Heijboer, MD PhD, Tanja Netelenbos, MD PhD, Bart J. Biemond, MD PhD, Erfan Nur, MD PhD

Blood (2019) 134 (Supplement_1): 1024.

https://doi.org/10.1182/blood-2019-130248

Published: 2019

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Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Sickle marrow: double, double toil and trouble

Fetal Hemoglobin Promotes P. Falciparum Growth in Sickle Cell Disease Erythrocytes

Profound Alteration of Host Response in Severe Malarial Anemia By Sickle Cell Disease: Reduction of Parasite Sequestration and Inflammation, Upregulation of Angiopoietin-2

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Crizanlizumab Treatment Is Associated with Clinically Significant Reductions in Hospitalization in Patients with Sickle Cell Disease: Results from the Sustain Study

Iron Restriction Improves Markers of Disease Severity in the Townes Mouse Model of Sickle Cell Anemia

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

The Oxygenscan Provides Clinically Relevant Biomarkers for Treatment Efficacy That Are Associated with Frequency of Vaso-Occlusive Crisis in Sickle Cell Disease

Unusually High Prevalence of Silent Stroke and Cerebral Vasculopathy in Hemoglobin SC Disease

Benefit and Safety of Isovolemic Hemodilution Prior to Red Cell Exchange in Chronically Transfused Sickle Cell Patients

Cannabidiol Reduces Acute and Chronic Hyperalgesia in Humanized Sickle Mice

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Implementation of a Standard Order Set at a Sickle Cell Acute Care Observation Unit

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

Unswitched Memory B Cell Deficiency Is Associated with Acute Chest Syndrome and Stroke in Sickle Cell Disease

The Effect of Crizanlizumab Plus Standard of Care (SoC) Versus Soc Alone on Renal Function in Patients with Sickle Cell Disease and Chronic Kidney Disease: A Randomized, Multicenter, Open-Label, Phase II Study (STEADFAST)

Complications of Extra Fluid Therapy (Hyperhydration) in Sickle Cell Patients during Vaso-Occlusive Painful Crisis

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