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Journal Articles

Enumerating Functional HSC Clones in the Zebrafish Using Gestalt

Emily M Teets, B.S., Charles Thomas Gregory, BS, Jami L Shaffer, B.S., James S. Blachly, MD, Bradley W Blaser, MD PhD

Blood (2019) 134 (Supplement_1): 3724.

https://doi.org/10.1182/blood-2019-131503

Published: 2019

Journal Articles

Mapping the Road of Gvhd and GVT: A Longitudinal Study of Immune-Transcriptome Signatures As Novel Approach to Solve Post-Allogeneic Hematopoietic Cell Transplantation Dilemmas

Merav Bar, MD, Alice Woo, Mohammed Toufiq, Sabri Boughorbel, Darawan Rinchai, Mohammed Elanbari, Valentina Mattei, Rebecca Mathew, Irene Cavattoni, MD, Sabine Forer, Marco Zecca, Patrizia Comoli, Giovanni Grillo, MD, Catherine Cole, Chiara Cugno, MD, Sara Tomei, PhD, Damien Chaussabel, Sara Deola

Blood (2019) 134 (Supplement_1): 4550.

https://doi.org/10.1182/blood-2019-122884

Published: 2019

Journal Articles

A Highly Robust Model for Predicting Outcome of Multiple Myeloma Patients By Inferring Patient-Specific Transcription Factor Activity

Chuanpeng Dong, MS, Christina Y Yu, BSc, Travis S Johnson, MS, Jill L Reiter, PhD, Mohammad Issam Abu Zaid, MBBS, Rafat Abonour, MD, G. David Roodman, MD PhD, Kun Huang, PhD, Yunlong Liu, PhD

Blood (2019) 134 (Supplement_1): 1785.

https://doi.org/10.1182/blood-2019-131962

Published: 2019

Journal Articles

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Heidi M Schmidt, BSE, Eric Kelley, PhD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3529.

https://doi.org/10.1182/blood-2019-130274

Published: 2019

Journal Articles

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Christina Caruso, MD, Xiao Zhang, BS, Yumiko Sakurai, MSc, Wei Li, MD, Meredith E. Fay, BS, Marcus A. Carden, MD, David R. Myers, PhD, Robert G. Mannino, PhD, Clinton H. Joiner, MD PhD, Michael D. Graham, PhD, Wilbur A. Lam, MD PhD

Blood (2019) 134 (Supplement_1): 3560.

https://doi.org/10.1182/blood-2019-125408

Published: 2019

Journal Articles

Application of Single Cell Technologies to the Study of Hematopoiesis

Bertie Gottgens, DPhil

Blood (2019) 134 (Supplement_1): SCI-19.

https://doi.org/10.1182/blood-2019-132314

Published: 2019

Journal Articles

A Computational Based Approach for Identification and Validation of Gene Mutations As Surrogate Markers of Gene Essentiality in Acute Myeloid Leukemia

Fernando Carazo, Edurne San Jose, Leire Garate, Estibaliz Miranda, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Bruno Paiva, PhD, Jesús San-Miguel, Xabier Agirre, PhD, Felipe Prósper, MD PhD, Angel Rubio

Blood (2019) 134 (Supplement_1): 1414.

https://doi.org/10.1182/blood-2019-126506

Published: 2019

Journal Articles

SHP-1 As a Negative Regulator of FLT3 Associated Aberrant Signaling and a New Potential Target to FLT3-ITD Mutation

Tongjuan Li, MD PhD, Dan Li, Lei Zhao, MD, Jue Wang, MD PhD, Zhen Shang, MD PhD, Yicheng Zhang, MD PhD, Liang Huang, MD PhD, Jianfeng Zhou, PhD

Blood (2018) 132 (Supplement 1): 4051.

https://doi.org/10.1182/blood-2018-99-115793

Published: 2018

Journal Articles

Computational Modelling of Multiple Myeloma Patient Genomic Signatures to Predict Treatment Outcome

Aneel Paulus, MD, Prachi Jani, MD, Salman Ahmed, MD, Sonikpreet Aulakh, MD, Alak Manna, PhD, Neeraj Kumar Singh, B.Tech, Mohammed Sauban, B.E, Zakir Husain, M.Tech, Ansu Kumar, M.Sc., Pallavi Kumari, M.Sc., Anuj Tyagi, M.Sc., Taimur Sher, MD, Rami Manochakian, MD, Vivek Roy, MD, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Asher A. Chanan-Khan, MD, Sikander Ailawadhi

Blood (2018) 132 (Supplement 1): 1911.

https://doi.org/10.1182/blood-2018-99-119574

Published: 2018

Journal Articles

Split First Dose Administration of Daratumumab for the Treatment of Patients with Multiple Myeloma (MM): Clinical Pharmacology and Population Pharmacokinetic (PK) Analyses

Xu Steven Xu, Philippe Moreau, Saad Z. Usmani, MD, Sagar Lonial, MD, Andrzej Jakubowiak, MD PhD, Albert Oriol, MD, Amrita Krishnan, MD, Joan Bladé, MD PhD, Melody Luo, PhD, Yu-Nien Sun, PhD, Liping Zhang, William Deraedt, Ming Qi, MD PhD, Jon Ukropec, PhD, Pamela L Clemens, PhD

Blood (2018) 132 (Supplement 1): 1970.

https://doi.org/10.1182/blood-2018-99-113171

Published: 2018

Journal Articles

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Andrej Besse, M.Sc, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD, Shireen Vali, PhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Neha G Gupta, M.Sc., Abha Kushwaha, M.Sc., Pallavi Kumari, M.Sc., Karthik Sundara Raju, M.Sc., Ganesh Naga, B.Tech, Sayani Basu, M.Tech, Christoph Driessen, MD, Lenka Besse, PhD

Blood (2018) 132 (Supplement 1): 3193.

https://doi.org/10.1182/blood-2018-99-116939

Published: 2018

Journal Articles

Toward a Proteome-Complete Computational Model of the Human Red Blood Cell

James T Yurkovich, PhD, Laurence Yang, PhD, Bernhard O Palsson, PhD

Blood (2018) 132 (Supplement 1): 4888.

https://doi.org/10.1182/blood-2018-99-114969

Published: 2018

Journal Articles

Computational Modeling and Microfluidics Reveal Characteristic Patterns of Regulation of Clot Structure and Mechanics By Tissue Factor Localization

Alexander Y. Mitrophanov, PhD, Vijay Govindarajan, PhD, Shu Zhu, PhD, Scott L. Diamond, PhD, Jaques Reifman, PhD

Blood (2018) 132 (Supplement 1): 1164.

https://doi.org/10.1182/blood-2018-99-111542

Published: 2018

Journal Articles

Data Driven Computational Modeling of Hematopoiesis in Myelodysplastic Syndromes Unveils Differences in Hematopoietic Stem Cell Kinetics Compared to Age-Matched Healthy Controls

Michèle Kyncl, MSc, Lisa Bast, MSc, Lynette Henkel, Fabian Theis, PhD, Robert A.J. Oostendorp, PhD, Carsten Marr, PhD, Katharina S. Götze, MD

Blood (2018) 132 (Supplement 1): 4354.

https://doi.org/10.1182/blood-2018-99-115942

Published: 2018

Journal Articles

Predictive Simulation Modeling in JAK2-Mutant MPNs Identified Ruxolitinib and Sorafenib As a Synergistic Drug Combination for Disease Modifying Therapy

Peter P. Sayeski, PhD, Leylah M. Drusbosky, PhD, Neeraj Kumar Singh, B.Tech, Anusha Pampana, Shahabuddin Usmani, MS, Mohammed Sauban, BE, Abha Kushwaha, Anu Ramakrishnan, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD

Blood (2017) 130 (Supplement 1): 5287.

https://doi.org/10.1182/blood.V130.Suppl_1.5287.5287

Published: 2017

Journal Articles

Novel CT-Based Bone Strength Assessment By Finite Element Analysis for Monitoring Bone Involvement in Myeloma: a Proof of Concept Study

Yael C Cohen, Irit Avivi, MD, Zohar Yosibash, DSc, Nir Trabelsi, PhD, Hagai Sherman, MD, Amir Sternheim

Blood (2017) 130 (Supplement 1): 3143.

https://doi.org/10.1182/blood.V130.Suppl_1.3143.3143

Published: 2017

Journal Articles

Predicting Mechanisms of Ibrutinib-Resistance in Chronic Lymphocytic Leukemia (CLL) Using Computational-Based Modeling for Personalized Therapy with Clinical Validation

Leylah M. Drusbosky, PhD, Aneel Paulus, MD, Anne Quillet Mary, PhD, Loic Ysebaert, MD PhD, Ansu Kumar, MS, Neeraj Kumar Singh, B.Tech, Yashaswini Ullal, BE, Priyanka Bhargav, BE, Humera Azam, MS, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Asher A. Chanan-Khan, MD, Christopher R. Cogle, MD

Blood (2017) 130 (Supplement 1): 4278.

https://doi.org/10.1182/blood.V130.Suppl_1.4278.4278

Published: 2017

Journal Articles

Predicting Response to IDH1/IDH2 Inhibitors Beyond IDH Mutations Using a Computational Model and Its Validation: A Beat AML Project Study

Leylah M. Drusbosky, PhD, Robinson Vidva, BT, Saji Gera, MT, Arko Das, MS, Krishna K Tiwari, BT, Vishwas Joseph, MS, Subrat Mohapatra, MS, Neelesh Lunkad, MT, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Cristina E. Tognon, PhD, Stephen E Kurtz, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Christopher R. Cogle, MD

Blood (2017) 130 (Supplement 1): 3907.

https://doi.org/10.1182/blood.V130.Suppl_1.3907.3907

Published: 2017

Journal Articles

Predicting Response to BET Inhibitors Using a Computational Model and Its Validation: A Beat AML Project Study

Leylah M. Drusbosky, PhD, Robinson Vidva, BT, Saji Gera, MT, Anjanasree V. Lakshminarayana, BE, Vijayashree P. Shyamasundar, MS, Ashish Kumar Agrawal, BS, Anay Talawdekar, MT, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Cristina E. Tognon, PhD, Stephen E Kurtz, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Christopher R. Cogle, MD

Blood (2017) 130 (Supplement 1): 3908.

https://doi.org/10.1182/blood.V130.Suppl_1.3908.3908

Published: 2017

Journal Articles

Digital Drug Screening and Computational Modeling Identifies Treatment Opportunities Despite Lack of Directly Actionable Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS)

Blood (2017) 130 (Supplement 1): 3910.

https://doi.org/10.1182/blood.V130.Suppl_1.3910.3910

Published: 2017

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Enumerating Functional HSC Clones in the Zebrafish Using Gestalt

Mapping the Road of Gvhd and GVT: A Longitudinal Study of Immune-Transcriptome Signatures As Novel Approach to Solve Post-Allogeneic Hematopoietic Cell Transplantation Dilemmas

A Highly Robust Model for Predicting Outcome of Multiple Myeloma Patients By Inferring Patient-Specific Transcription Factor Activity

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Application of Single Cell Technologies to the Study of Hematopoiesis

A Computational Based Approach for Identification and Validation of Gene Mutations As Surrogate Markers of Gene Essentiality in Acute Myeloid Leukemia

SHP-1 As a Negative Regulator of FLT3 Associated Aberrant Signaling and a New Potential Target to FLT3-ITD Mutation

Computational Modelling of Multiple Myeloma Patient Genomic Signatures to Predict Treatment Outcome

Split First Dose Administration of Daratumumab for the Treatment of Patients with Multiple Myeloma (MM): Clinical Pharmacology and Population Pharmacokinetic (PK) Analyses

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Toward a Proteome-Complete Computational Model of the Human Red Blood Cell

Computational Modeling and Microfluidics Reveal Characteristic Patterns of Regulation of Clot Structure and Mechanics By Tissue Factor Localization

Data Driven Computational Modeling of Hematopoiesis in Myelodysplastic Syndromes Unveils Differences in Hematopoietic Stem Cell Kinetics Compared to Age-Matched Healthy Controls

Predictive Simulation Modeling in JAK2-Mutant MPNs Identified Ruxolitinib and Sorafenib As a Synergistic Drug Combination for Disease Modifying Therapy

Novel CT-Based Bone Strength Assessment By Finite Element Analysis for Monitoring Bone Involvement in Myeloma: a Proof of Concept Study

Predicting Mechanisms of Ibrutinib-Resistance in Chronic Lymphocytic Leukemia (CLL) Using Computational-Based Modeling for Personalized Therapy with Clinical Validation

Predicting Response to IDH1/IDH2 Inhibitors Beyond IDH Mutations Using a Computational Model and Its Validation: A Beat AML Project Study

Predicting Response to BET Inhibitors Using a Computational Model and Its Validation: A Beat AML Project Study

Digital Drug Screening and Computational Modeling Identifies Treatment Opportunities Despite Lack of Directly Actionable Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS)

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