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Journal Articles

High Mobility Group A1 Chromatin Regulators Function As Critical Drivers of Leukemogenesis in Preclinical Models of Relapsed, Pediatric B-Cell ALL

Free
Liping Li, MD PhD, Katharina Hayer, Lingling Xian, MD PhD, Li Luo, PhD, Leslie Cope, Andrei Thomas-Tikhonenko, PhD, Linda Resar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3946.
https://doi.org/10.1182/blood-2019-130261
Published: 2019
Journal Articles

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Free
Katarzyna Szoltysek, PhD, Helen Blair, Sirintra Nakjang, Ricky Tirtakusuma, Mankaran Singh, Ryan Nelson, Hesta McNeill, Catherine Dodd, Melanie Beckett, Lynsey McKenzie, Edward Law, Josef Vormoor, MD PhD, Deepali Pal, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 3952.
https://doi.org/10.1182/blood-2019-124818
Published: 2019
Journal Articles

Mesothelin Targeting Bites for Pediatric AML: In Vivo Efficacy and Specificity

Free
Anilkumar Gopalakrishnapillai, PhD, Colin Correnti, PhD, Anne Kisielewski, BS, Allison Kaeding, MD, Soheil Meshinchi, MD PhD, E. Anders Kolb, MD, Sonali Barwe, PhD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 3925.
https://doi.org/10.1182/blood-2019-130941
Published: 2019
Journal Articles

A Distinct Oncofetal B-Cell Transcriptional Program Is Activated in Infant Acute Myeloid Leukemia and Reveals Novel Therapeutic Strategies

Free
Hamid Bolouri, PhD, Benjamin K. Johnson, PhD, Rhonda E. Ries, MA, Laura Pardo, Tiffany A. Hylkema, BS, Wanding Zhou, PhD, Jenny L. Smith, MSc, MD, Amanda R. Leonti, MS, Allison Kaeding, MD, Michael R. Loken, PhD, Jason E. Farrar, MD, Soheil Meshinchi, MD PhD, Timothy Junius Triche, Jr., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3768.
https://doi.org/10.1182/blood-2019-123487
Published: 2019
Journal Articles

Investigation of Cell-Contact Dependent Alterations in Immune Synapse Formation between T Cells and BCP-ALL Cells

Free
Britta Wenske, PhD, Lothar Marischen, PhD, Julia Welzenbach, André Heimbach, PhD, Per Hoffmann, PhD, Selim Corbacioglu, MD, David A Williams, MD, Anja Troeger, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2754.
https://doi.org/10.1182/blood-2019-128835
Published: 2019
Journal Articles

Establishing a Novel in Vitro Informed Precision Clinical Trial Pathway for Refractory Pediatric Leukemia

Free
Chunfen Zhang, MD, Ritul Sharma, MSc., Thakur Satbir, PhD, Allison Cheney, Olena Vaske, PhD, Lauren Sanders, Jessica Boklan, MD, Victor A. Lewis, MD, Ronald Anderson, MDFRCPC, Olga Kovalchuk, MD, PhD, Norman J. Lacayo, MD, Aru Narendran, MD PhD, Kevin J. Bielamowicz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2633.
https://doi.org/10.1182/blood-2019-131444
Published: 2019
Journal Articles

Evaluating ROR1 As a Target in Childhood Leukemia

Free
Paraskevi Diamanti, PhD, Bethan Kathleen Bailey, BSc, Obinna Ebere Iheanacho, MD, Amit C. Nathwani, MD PhD, Allison Blair, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2635.
https://doi.org/10.1182/blood-2019-126734
Published: 2019
Journal Articles

Recurrent Gene Mutations in Pediatric Patients with AML By Targeted Sequencing ―the Jccg Study, JPLSG AML-05―

Free
Taeko Kaburagi, MD, Genki Yamato, MD PhD, Norio Shiba, Kenichi Yoshida, MD PhD, Yusuke Hara, Yuichi Shiraishi, PhD, Kentaro Ohki, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Hidemasa Matsuo, PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Keizo Horibe, MD PhD, Satoru Miyano, PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Seishi Ogawa, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2697.
https://doi.org/10.1182/blood-2019-126545
Published: 2019
Journal Articles

Clinical Features of Pediatric Acute Myeloid Leukemia with TP53 and CDKN2A / 2B copy Number Alterations

Free
Yusuke Hara, Tomohiko Taki, MD PhD, Genki Yamato, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD PhD, Norio Shiba, MD PhD, Taeko Kaburagi, MD, Yuichi Shiraishi, PhD, Kentaro Ohki, MD PhD, Machiko Kawamura, MD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Hidemasa Matsuo, PhD, Akira Shimada, MD PhD, Tsutomu Toki, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Keizo Horibe, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2727.
https://doi.org/10.1182/blood-2019-126263
Published: 2019
Journal Articles

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Free
Elvin Wagenblast, PhD, Olga I. Gan, PhD, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, MD, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Johann K. Hitzler, MD, Eric R. Lechman, PhD, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2531.
https://doi.org/10.1182/blood-2019-129259
Published: 2019
Journal Articles

Intensive Chemotherapy Along with Aggressive Supportive Care Can Spare Stem Cell Transplantation in a Subset of Patients without Compromising an Outcome in Infants with Acute Lymphoblastic Leukemia; A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Trial MLL-10

Free
Daisuke Tomizawa, MD PhD, Takako Miyamura, MD PhD, Toshihiko Imamura, MD PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD PhD, Atsushi Ogawa, MD PhD, Yoshihiro Takahashi, MD PhD, Masahiro Hirayama, MD PhD, Yuki Arakawa, MD, Tomohiko Taki, MD PhD, Takao Deguchi, MD PhD, Toshinori Hori, MD PhD, Sakae Omori, PhD, Masami Haba, PhD, Akihiro Iguchi, MD PhD, Yuuki Koga, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Eiichi Ishii, MD PhD, Katsuyoshi Koh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2626.
https://doi.org/10.1182/blood-2019-121328
Published: 2019
Journal Articles

Significant Features of DNA Methylation at Bivalent Promotor and Repressed Polycomb Regions in Pediatric AML-the Jccg Study, JPLSG AML-05-

Free
Genki Yamato, Tomoko Kawai, PhD, Norio Shiba, Yusuke Hara, Kentaro Ohki, MD PhD, Taeko Kaburagi, MD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Akira Shimada, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Souichi Adachi, MD PhD, Takashi Taga, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Kenichiro Hata, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2739.
https://doi.org/10.1182/blood-2019-125025
Published: 2019
Journal Articles

Predictive Factors of the Development of Leukemia in Patients with Transient Abnormal Myelopoiesis and Down Syndrome: The Jccg Study JPLSG TAM-10

Free
Genki Yamato, MD PhD, Hideki Muramatsu, MD PhD, Tomoyuki Watanabe, PhD, Takao Deguchi, MD PhD, Shotaro Iwamoto, MD, Daisuke Hasegawa, MD PhD, Kiminori Terui, MD PhD, Takahiro Ueda, MD PhD, Tomoko Yokosuka, Tsutomu Toki, PhD, Shiro Tanaka, PhD, Ryu Yanagisawa, Katsuyoshi Koh, MD, Akiko M Saito, MD PhD, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD PhD, Shuki Mizutani, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Kenichiro Watanabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3833.
https://doi.org/10.1182/blood-2019-125465
Published: 2019
Journal Articles

Post-Induction Minimal Residual Disease Measured By Flow Cytometry and Deep Sequencing of Mutant GATA1 Are Both Significant Prognostic Factors for Children with Myeloid Leukemia and Down Syndrome: A Nationwide Prospective Study of the Japanese Pediatric Leukemia/Lymphoma Study Group

Free
Takashi Taga, MD PhD, Shiro Tanaka, PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD, Hidefumi Hiramatsu, MD PhD, Takako Miyamura, MD PhD, Yoshiko Hashii, MD PhD, Daisuke Hasegawa, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Katsuyoshi Koh, MD, Daiichiro Hasegawa, MD PhD, Asahito Hama, MD PhD, Akiko M Saito, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3848.
https://doi.org/10.1182/blood-2019-123302
Published: 2019
Journal Articles

Assessment of Provider Practices Regarding Management of VTE in Pediatric Leukemia

Free
Melanie Degliuomini, MD, Victoria Cooley, MS, Elizabeth Mauer, MS, Linda M Gerber, PhD, Suchitra Acharya, MD, Nicole Kucine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3398.
https://doi.org/10.1182/blood-2019-127428
Published: 2019
Journal Articles

Adoptively Transferred Donor-Derived Cytokine Induced Memory-like NK Cells Persist and Induce Remission in Pediatric Patient with Relapsed Acute Myeloid Leukemia after Hematopoietic Cell Transplantation

Free
Jeffrey J. Bednarski, MD PhD, Clare Zimmerman, MD, Amanda F Cashen, MD, Sweta Desai, Mark Foster, Tim Schappe, BS, Ethan McClain, Michelle Becker-Hapak, BS, Melissa M Berrien-Elliott, PhD, Todd A Fehniger, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3307.
https://doi.org/10.1182/blood-2019-126982
Published: 2019
Journal Articles

Induction of a Leukemic Bone Marrow Niche Mediated By TGFB1 of Leukemic Blasts in Pediatric Acute Mekaryoblastic Leukemia: Results of an in Vitro and In Vivo Analysis

Free
Theresa Hack, MSc, Stefanie Bertram, MD, Guntram Büsche, MD, Helmut Hanenberg, MD, Ludger Klein-Hitpass, PhD, Nils Von Neuhoff, PhD, Dirk Reinhardt, MD, Markus Schneider, PhD, Mareike Rasche, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3734.
https://doi.org/10.1182/blood-2019-126536
Published: 2019
Journal Articles

SETBP1 Mutations Accelerate NRAS-Mutant Leukemia

Free
Sarah A Carratt, PhD BS, Zachary Schonrock, BS, Theodore Braun, MD PhD, Cody Coblentz, Amy Foley, MEng., Julia E. Maxson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1254.
https://doi.org/10.1182/blood-2019-125125
Published: 2019
Journal Articles

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

Free
Sorcha Isabella O'Byrne, BSc, Natalina Elliott, PhD, Gemma Buck, BSc, Siobhan Rice, David O'Connor, Jana Oswald, Hannah Fuchs, Ella-Mae Labbett, Nicholas James Fordham, MBBS, BSc, Anindita Roy, MD PhD, Irene Roberts
Journal: Blood
Blood (2019) 134 (Supplement_1): 1206.
https://doi.org/10.1182/blood-2019-130180
Published: 2019
Journal Articles

TPA Use for Central Line De-Occlusion and Its Relationship to Symptomatic Venous Thromboembolism in Pediatric Leukemia Patients

Free
Katherine Armstrong, MD, Kavitha Ramaswamy, MD, Victoria Cooley, MS, Linda M Gerber, PhD, Nicole Kucine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2111.
https://doi.org/10.1182/blood-2019-130315
Published: 2019