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Journal Articles

Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients

Florian Lignet, Christina Esdar, Manja Friese-Hamim, Andreas Becker, Elise Drouin, Samer El Bawab, Samantha M. Goodstal, Claude Gimmi, Phlipp Haselmayer, Frank Jährling, Michael Sanderson, Willem Sloot, Sofia Stinchi, Anja Victor, Gina Walter, Felix Rohdich

Blood (2019) 134 (Supplement_1): 5582.

https://doi.org/10.1182/blood-2019-126972

Published: 2019

Journal Articles

Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo

Carsten Dan Ley, PhD, Thomas Lindebo Holm, PhD, Daniel Elenius, PhD, Heidi Lindgreen Holmberg, PhD, Jais Rose Bjelke, PhD, Mette Loftager, PhD, Mette B Hermit, PhD, Ida Hilden, Stine L Kjellev, PhDDVM

Blood (2019) 134 (Supplement_1): 3631.

https://doi.org/10.1182/blood-2019-128159

Published: 2019

Journal Articles

CAR-T Cells Targeting gp350 Recognize Immortalized Cells Latently Infected with EBV

Simon Danisch, PhD, Constanze Slabik, Reinhard Zeidler, Prof., Arnold Ganser, MD, Renata Stripecke, Prof.

Blood (2018) 132 (Supplement 1): 4540.

https://doi.org/10.1182/blood-2018-99-113436

Published: 2018

Journal Articles

A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of the Pharmacokinetics and Pharmacodynamics of REGN3918, a Human Antibody Against Complement Factor C5, in Healthy Volunteers

Jonathan Weyne, MD, Yan Ni, PhD, Richard DelGizzi, PA, MS, Stephen Godin, PhD, Lori Morton, PhD, Srinivasa Prasad, PhD, Andrew J Rankin, PhD, Melissa Simek-Lemos, MPH, ming-Dauh Wang, PhD, Ronda Rippley, PhD, Olivier Harari, MD PhD

Blood (2018) 132 (Supplement 1): 1039.

https://doi.org/10.1182/blood-2018-99-112262

Published: 2018

Journal Articles

A Novel Full Length Anti-FLT3 CD3 Bispecific Antibody for the Treatment of Acute Myeloid Leukemia

Ivana Djuretic, PhD, Veena Krishnamoorthy, PhD, Cesar Sommer, PhD, Danielle E. Dettling, Kris Poulsen, Wei Chen, PhD, Wenyue Hu, PhD, Allison Given Chunyk, Kevin Lindquist, Shobha Potluri, PhD, Robert C Rickert, PhD, Barbra Sasu, PhD, Javier Chaparro-Riggers, PhD, Yik Andy Yeung, PhD

Blood (2018) 132 (Supplement 1): 1445.

https://doi.org/10.1182/blood-2018-99-119915

Published: 2018

Journal Articles

Pharmacokinetic and Pharmacodynamic Study of NKTR-255, a Polymer-Conjugated Human IL-15, in Cynomolgus Monkey

Takahiro Miyazaki, Peiwen Kuo, Mekhala Maiti, Palakshi Obalapur, Murali Addepalli, Werner Rubas, Paul Sims, Ping Zhang, Mario Q. Marcondes, MD PhD, Loui Madakamutil, Jonathan Zalevsky

Blood (2018) 132 (Supplement 1): 2952.

https://doi.org/10.1182/blood-2018-99-115638

Published: 2018

Journal Articles

Investigating Potential Mechanism(s) By Which ASO-Based Drugs Cause Thrombocytopenia

Martina H. Lundberg Slingsby, PhD, Genevieve Couldwell, Prakrith Vijey, Brooke E Terkovich, Leila Noetzli, PhD, Ross Okazaki, Jonathan N. Thon, PhD, Scott P. Henry, PhD, Padmakumar Narayanan, DVM, PhD, Joseph E. Italiano, Jr., PhD

Blood (2018) 132 (Supplement 1): 3747.

https://doi.org/10.1182/blood-2018-99-116590

Published: 2018

Journal Articles

A Novel RAD51 Inhibitor, CYT01B, Shows Anti-Cancer Activity in Preclinical Models of Aid Expressing Lymphomas

Muneer G Hasham, PhD, Darryl Patrick, Leanne Bedard, Joseph Vacca, Casey McComas, Alfredo Castro, Melinda Day, PhD, Kevin Mills, PhD

Blood (2018) 132 (Supplement 1): 2944.

https://doi.org/10.1182/blood-2018-99-119351

Published: 2018

Journal Articles

A Single Administration of the Cytolytic CD38 Antibody TAK-079 to Healthy Subjects: Tolerability, Pharmacokinetics and Pharmacodynamics

Eric Robert Fedyk, PhD, Deborah Berg, RN, MSN, Glenda Smithson, PhD, Jose Estevam, Lachy Mclean, MD PhD, Kristina Allikmets, MD PhD, Antonio Palumbo, MD

Blood (2018) 132 (Supplement 1): 3249.

https://doi.org/10.1182/blood-2018-99-112916

Published: 2018

Journal Articles

Characterization of a HBB -Locus Fetal Chromatin Domain Region during Adult Erythropoiesis

Li Liu, PhD, Xingguo Zhu, PhD, Alexander Yu, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 2223.

https://doi.org/10.1182/blood.V130.Suppl_1.2223.2223

Published: 2017

Journal Articles

Predictable Protein Expression with Enhanced Factor IX Activity Following Administration of a Modified AAV5-hFIX Vector to Nonhuman Primates

Ying Poi Liu, PhD, Jacek Lubelski, PhD, Erich Ehlert, PhD, Sander Gielen, PhD, Paula Miranda, PhD, Martin de Haan, Bart Nijmeijer, PhD, Harald Petry, PhD

Blood (2017) 130 (Supplement 1): 2058.

https://doi.org/10.1182/blood.V130.Suppl_1.2058.2058

Published: 2017

Journal Articles

Intramuscular Administration of Placenta-Derived Stromal Cells Enhances Survival of Rhesus Macaque Monkeys Exposed to Total Body Irradiation

Noa Sher, PhD, Tal Prezma, Dana Fuchs-Telem, Niva Shraga- Heled, Simon Authier, Polly Chang, Alexis Ascah, James Bakke, Janet Gahagen, Racheli Ofir, PhD

Blood (2017) 130 (Supplement 1): 3784.

https://doi.org/10.1182/blood.V130.Suppl_1.3784.3784

Published: 2017

Journal Articles

Trph-222, a Novel Anti-CD22 Antibody Drug Conjugate (ADC), Has Signficant Anti-Tumor Activity in NHL Xenografts and Is Well Tolerated in Non-Human Primates

Ann Maclaren, PhD BS, Nancy Levin, PhD, Henry Lowman, PhD, Mohit Trikha, PhD

Blood (2017) 130 (Supplement 1): 4105.

https://doi.org/10.1182/blood.V130.Suppl_1.4105.4105

Published: 2017

Journal Articles

CTLA4-FasL, the Hexameric Targeted FasL Fusion Protein, As Potential Novel Treatment for DLBCL

Alexandra Aronin, PhD, Liat Ben Gigi-Tamir, PhD, Efi Makdasi, PhD, Shira Amsili, PhD, Shlomi Ben David, Ortal Avraham, Yehudith Jitka Sagiv, Yosi Meir Gozlan, PhD, Noam Shani, PhD, Michal Dranitzki Elhalel, MD MSc

Blood (2017) 130 (Supplement 1): 4107.

https://doi.org/10.1182/blood.V130.Suppl_1.4107.4107

Published: 2017

Journal Articles

Impact of Pre-Existing Immunogenicity to AAV on Vector Transduction By Bmn 270, an AAV5-Based Gene Therapy Treatment for Hemophilia A

Brian Long, PhD MS, BSMedTech, Krystal Sandza, Jennifer Holcomb, Juli Pherarolis, Lucy Crockett, Lillian Falese, Greg Hayes, Jeremy Arens, Charles A. O'Neill, Nancy Pryer, Carlos Fonck, Stephen Zoog, Christian Vettermann

Blood (2017) 130 (Supplement 1): 3332.

https://doi.org/10.1182/blood.V130.Suppl_1.3332.3332

Published: 2017

Journal Articles

Strict tropism for CD71 + /CD234 + human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi

Varakorn Kosaisavee, Rossarin Suwanarusk, Adeline C. Y. Chua, Dennis E. Kyle, Benoit Malleret, Rou Zhang, Mallika Imwong, Rawiwan Imerbsin, Ratawan Ubalee, Hugo Sámano-Sánchez, Bryan K. S. Yeung, Jessica J. Y. Ong, Eric Lombardini, François Nosten, Kevin S. W. Tan, Pablo Bifani, Georges Snounou, Laurent Rénia, Bruce Russell

Blood (2017) 130 (11): 1357–1363.

https://doi.org/10.1182/blood-2017-02-764787

Published: 2017

Includes: Supplemental data

Journal Articles

The Histone Deacetylase 1 and 2 (HDAC1/2) Inhibitor ACY-957: Impact of Dosing Schedule on Pharmacokinetics (PK), Pharmacodynamics (PD), Hematopoietic Toxicity, and Gamma Globin (HBG, ɣ) Expression in Monkey

Apurva Chonkar, MS, Matthew Jarpe, PhD, Kailash Bhol, PhD, Simon S Jones, PhD, Jeffrey R Shearstone, PhD

Blood (2016) 128 (22): 323.

https://doi.org/10.1182/blood.V128.22.323.323

Published: 2016

Journal Articles

The Bruton's Tyrosine Kinase (BTK) Inhibitor ARQ 531 Effectively Inhibits Wild Type and C481S Mutant BTK and Is Superior to Ibrutinib in a Mouse Model of Chronic Lymphocytic Leukemia

Sean D. Reiff, Rose Mantel, Lisa L. Smith, MS, Samantha McWhorter, Virginia M. Goettl, DVM , PhD, Amy J. Johnson, PhD, Sudharsan Eathiraj, Giovanni Abbadessa, MD, Brian Schwartz, MD, John C. Byrd, MD, Jennifer A. Woyach, MD

Blood (2016) 128 (22): 3232.

https://doi.org/10.1182/blood.V128.22.3232.3232

Published: 2016

Journal Articles

Administration of the Dual E-Selectin/CXCR4 Antagonist, GMI-1359, Results in a Unique Profile of Tumor Mobilization from the Bone Marrow and Facilitation of Chemotherapy in a Murine Model of FLT3 ITD AML

William E. Fogler, PhD, Henry Flanner, MS, Curt Wolfgang, PhD, Jeffrey Allen Smith, Helen M. Thackray, MD, John L Magnani, PhD

Blood (2016) 128 (22): 2826.

https://doi.org/10.1182/blood.V128.22.2826.2826

Published: 2016

Journal Articles

Nonclinical Safety of SHP 826 (BAX 826), a Next Generation Extended Half-Life Recombinant Factor VIII Product

Veronika Ehrlich, Peter Leidenmuehler, Barbara Dietrich, Gerald Hoebarth, Tanja Ruthsatz, Peter L. Turecek, PhD, Martin Wolfsegger, Cstat (RSS), Alfred Weber, Herbert Gritsch, Werner Hoellriegl, Marietta Turecek

Blood (2016) 128 (22): 4977.

https://doi.org/10.1182/blood.V128.22.4977.4977

Published: 2016

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Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients

Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo

CAR-T Cells Targeting gp350 Recognize Immortalized Cells Latently Infected with EBV

A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of the Pharmacokinetics and Pharmacodynamics of REGN3918, a Human Antibody Against Complement Factor C5, in Healthy Volunteers

A Novel Full Length Anti-FLT3 CD3 Bispecific Antibody for the Treatment of Acute Myeloid Leukemia

Pharmacokinetic and Pharmacodynamic Study of NKTR-255, a Polymer-Conjugated Human IL-15, in Cynomolgus Monkey

Investigating Potential Mechanism(s) By Which ASO-Based Drugs Cause Thrombocytopenia

A Novel RAD51 Inhibitor, CYT01B, Shows Anti-Cancer Activity in Preclinical Models of Aid Expressing Lymphomas

A Single Administration of the Cytolytic CD38 Antibody TAK-079 to Healthy Subjects: Tolerability, Pharmacokinetics and Pharmacodynamics

Characterization of a HBB -Locus Fetal Chromatin Domain Region during Adult Erythropoiesis

Predictable Protein Expression with Enhanced Factor IX Activity Following Administration of a Modified AAV5-hFIX Vector to Nonhuman Primates

Intramuscular Administration of Placenta-Derived Stromal Cells Enhances Survival of Rhesus Macaque Monkeys Exposed to Total Body Irradiation

Trph-222, a Novel Anti-CD22 Antibody Drug Conjugate (ADC), Has Signficant Anti-Tumor Activity in NHL Xenografts and Is Well Tolerated in Non-Human Primates

CTLA4-FasL, the Hexameric Targeted FasL Fusion Protein, As Potential Novel Treatment for DLBCL

Impact of Pre-Existing Immunogenicity to AAV on Vector Transduction By Bmn 270, an AAV5-Based Gene Therapy Treatment for Hemophilia A

Strict tropism for CD71 + /CD234 + human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi

The Histone Deacetylase 1 and 2 (HDAC1/2) Inhibitor ACY-957: Impact of Dosing Schedule on Pharmacokinetics (PK), Pharmacodynamics (PD), Hematopoietic Toxicity, and Gamma Globin (HBG, ɣ) Expression in Monkey

The Bruton's Tyrosine Kinase (BTK) Inhibitor ARQ 531 Effectively Inhibits Wild Type and C481S Mutant BTK and Is Superior to Ibrutinib in a Mouse Model of Chronic Lymphocytic Leukemia

Administration of the Dual E-Selectin/CXCR4 Antagonist, GMI-1359, Results in a Unique Profile of Tumor Mobilization from the Bone Marrow and Facilitation of Chemotherapy in a Murine Model of FLT3 ITD AML

Nonclinical Safety of SHP 826 (BAX 826), a Next Generation Extended Half-Life Recombinant Factor VIII Product

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