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Journal Articles

Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy

Rebecca A. Gardner, Francesco Ceppi, Julie Rivers, Colleen Annesley, Corinne Summers, Agne Taraseviciute, Juliane Gust, Kasey J. Leger, Katherine Tarlock, Todd M. Cooper, Olivia C. Finney, Hannah Brakke, Daniel H. Li, Julie R. Park, Michael C. Jensen
Journal: Blood
Blood (2019) 134 (24): 2149–2158.
https://doi.org/10.1182/blood.2019001463
Published: 2019
Includes: Supplemental data
Journal Articles

C/EBPβ Isoforms Regulate Proliferation and Differentiation of Regenerating Hematopoietic Stem/Progenitor Cells

Atsushi Sato, MD, Asumi Yokota, PhD, Yoshihiro Hayashi, MD PhD, Naoka Kamio, MD, Satoshi Sagai, Taira Maekawa, MD PhD, Hideyo Hirai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3713.
https://doi.org/10.1182/blood-2019-128026
Published: 2019
Journal Articles

R-BAC Maintains High Response Rate in Mantle Cell Lymphoma Following Relapse on BTK Inhibitor Therapy

Rory McCulloch, FRCPath, MRCP, MBBS, Carlo Visco, Rebecca Frewin, Neil Phillips, Toby A. Eyre, David Tucker, MD, Francesca M. Quaglia, Annabel McMillan, Jonathan Lambert, Nicola Crosbie, Simon Rule
Journal: Blood
Blood (2019) 134 (Supplement_1): 3989.
https://doi.org/10.1182/blood-2019-129829
Published: 2019
Journal Articles

Nicotinamide (NAM) Modulates Transcriptional Signature of Ex Vivo Cultured UCB CD34+ Cells (Omidubicel) and Preserves Their Stemness and Engraftment Potential

Tracey Lodie, PhD, Julian Adams, PhD, Dima Yackoubov, Msc, Yair Steinhardt, MSc, Dorit Ashengrau, Adi Bitansky, Alina Maliutina, Sherry Cohen, Boaz Buhenvald, PhD, Moshe Shahor, PhD, Nathan Dinowitz, PhD, Vered Caspi, PhD, Amnon Peled, PhD, Tony Peled, MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 3718.
https://doi.org/10.1182/blood-2019-131124
Published: 2019
Journal Articles

Hmga2 Functions As an Oncogene upon the Deletion of Tet2 and Promotes the Pathogenesis of Myelodysplastic Syndrome

Jie Bai, Sho Kubota, PhD, Takako Yokomizo, PhD, Akinori Kanai, PhD, Yuqi Sun, MD, Mihoko Iimori, CLS, Hironori Harada, MD PhD, Naomi Nakagata, PhD, Atsushi Iwama, MD PhD, Goro Sashida, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3782.
https://doi.org/10.1182/blood-2019-127583
Published: 2019
Journal Articles

Ibrutinib at First Relapse for Mantle Cell Lymphoma: A United Kingdom Real World Analysis of Outcomes in 169 Patients

Rory McCulloch, FRCPath, MRCP, MBBS, Simon Rule, Toby A. Eyre, Harshita Goradia, Simon Bolam, MD, Thomas Creasey, MBBS, David Tucker, MD, Michelle Furtado, Oliver Miles, Samuel Harrison, Amir Shenouda, Andrew Robinson, Matthew Wilson, MD BSc, MRCP, Annabel McMillan, Nimish Shah, Graham McIlroy, MD, David Dutton, MD, Adam Bond, Luke Attwell, Alexander Langridge, Helen Parry, MB ChB, MRCP, PhD, John Willan, Gavin Campbell, FRCP,FRCPath, Deborah Turner, David Lewis, PhD FRCPath, BSc, Helen McCarthy, MBBS, PhD, Jonathan Lambert, Pamela McKay, MD, Neil Phillips, Shankara Paneesha, MD, Wendy Osborne, MD, Mark Bishton, Nicola Crosbie
Journal: Blood
Blood (2019) 134 (Supplement_1): 3993.
https://doi.org/10.1182/blood-2019-125947
Published: 2019
Journal Articles

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

Shan Lin, Yusuke Tarumoto, Jinhua Wang, PhD, Joseph Milazzo, Yali Xu, Nathanael Gray, Christopher Vakoc, Kimberly Stegmaier, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3941.
https://doi.org/10.1182/blood-2019-125278
Published: 2019
Journal Articles

Treatment of Elderly Patients with Acute Promyelocytic Leukemia: A Real Life Experience of the "Rete Ematologica Lombarda"

Valentina Mancini, MD, Erika Borlenghi, MD, Livia Leuzzi, MD, Claudia Basilico, MD, Massimo Bernardi, MD, Patrizia Zappasodi, MD, Monica Fumagalli, MD, Elisabetta Todisco, MD PhD, Chiara Cattaneo, MD, Federico Lussana, MD, Giambattista Bertani, MD, Erika Ravelli, MD, Nicola Fracchiolla, Mauro Turrini, Giuseppe Rossi, Silvia Cantoni, Roberto Cairoli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3862.
https://doi.org/10.1182/blood-2019-130089
Published: 2019
Journal Articles

Ponatinib and Chemotherapy in Young Adults with De Novo Philadelphia Chromosome-Positive Acute Lymphoblstic Leukemia. Preliminary Results of Ponalfil Clinical Trial

Josep-Maria Ribera, MD PhD, Olga García, Pilar Martinez, MD, Pau Montesinos Fernandez, MD PhD, Blanca Boluda, Jordi Esteve, Daniel Esteban, María José Moreno, MD, Natalia Alonso, José González-Campos, MD, Arancha Bermúdez, Susana Vives, MD, Mar Tormo, MD PhD, Jesús María Hernández-Rivas, MD PhD, Joaquin Martinez-Lopez, MD PhD, Ramón García-Sanz, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3874.
https://doi.org/10.1182/blood-2019-125558
Published: 2019
Journal Articles

The Combination of Dexamethasone and Ruxolitinib Synergistically Attenuates Disease Manifestations in a Preclinical Model of Hemophagocytic Lymphohistiocytosis

Lauren K. Meyer, Katherine Verbist, PhD, Sabrin Albeituni, PhD, Rachel Bassett, Michelle L. Hermiston, MD PhD, Kim E. Nichols, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 81.
https://doi.org/10.1182/blood-2019-129112
Published: 2019
Journal Articles

Hemopexin Replacement Therapy Protects Sickle Cell Disease Mice from Acute Kidney Injury

Samit Ghosh, Oluwaseun Orikogbo, Rimi Hazra, Bethany Flage, Danielle Crosby, Solomon Fiifi Ofori-Acquah
Journal: Blood
Blood (2019) 134 (Supplement_1): 78.
https://doi.org/10.1182/blood-2019-127161
Published: 2019
Journal Articles

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Rimi Hazra, Samit Ghosh, Bethany Flage, Matthew Crouthamel, Clark Pan, Xiuxia Sun, Bohong Zhang, Joseph Sypek, Solomon Fiifi Ofori-Acquah
Journal: Blood
Blood (2019) 134 (Supplement_1): 74.
https://doi.org/10.1182/blood-2019-127198
Published: 2019
Journal Articles

Dose-Dependent Iron Chelating Effects of Eltrombopag on in Vitro Human Megakaryopoiesis

Zhi-Jian Liu, PhD, Emoke Deschmann, MD, Haley E. Ramsey, PhDMSc, Henry Feldman, Bethan Psaila, MD PhD, Nichola Cooper, MD MRCP, Evangelia Vlachodimtropoulou Koumoutsea, MBBS,PhDBSc, John B. Porter, MA MDFRCP FRCPath, James B. Bussel, MD, Michael Georgieff, MD, Martha Sola-Visner, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2475.
https://doi.org/10.1182/blood-2019-131895
Published: 2019
Journal Articles

A Lipid Peroxidation Product, 4-Hydroxy-2-Nonenal, Triggers Intravascular Coagulation and Inflammation through Generation of Tissue Factor-Positive Microvesicles

Shabbir Ansari, PhD, Shiva Keshava Gaddam Bala Krishna, PhD, Usha R. Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2383.
https://doi.org/10.1182/blood-2019-124498
Published: 2019
Journal Articles

Investigation of Cell-Contact Dependent Alterations in Immune Synapse Formation between T Cells and BCP-ALL Cells

Britta Wenske, PhD, Lothar Marischen, PhD, Julia Welzenbach, André Heimbach, PhD, Per Hoffmann, PhD, Selim Corbacioglu, MD, David A Williams, MD, Anja Troeger, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2754.
https://doi.org/10.1182/blood-2019-128835
Published: 2019
Journal Articles

Loss-of-Function and Gain-of-Function Consequences of GATA2 Disease Mutations

Koichi Ricardo Katsumura, MD PhD, Peng Liu, PhD, Charu Mehta, MS, Kyle J Hewitt, PhD, Alexandra Soukup, PhD, Isabela J Fraga de Andrade, Bachelors in Biological Science, Erik A. Ranheim, MD PhD, Kirby D Johnson, PhD, Emery H Bresnick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2519.
https://doi.org/10.1182/blood-2019-129447
Published: 2019
Journal Articles

Tipifarnib Modulates Interferon (IFN)-γ-Inducible Genes in Acute Myeloid Leukemia

Jayakumar Vadakekolathu, PhD, Stephen Reeder, BSc, Clare Coveney, PhD, Sergio Rutella, MDPhDFRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 2726.
https://doi.org/10.1182/blood-2019-124717
Published: 2019
Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Reina Takeda, MD, Shuhei Asada, MD PhD, Sung-Joon Park, PhD, Akihiko Yokoyama, PhD, Akinori Kanai, PhD, Valeria Visconte, PhD, Courtney Hershberger, BS, Yasutaka Hayashi, MD PhD, Taishi Yonezawa, MSc, Moe Tamura, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, PhD, Kenta Nakai, PhD, Toshiya Inaba, MD PhD, Tatsuhiro Shibata, MD PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Susumu Goyama, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2525.
https://doi.org/10.1182/blood-2019-126663
Published: 2019
Journal Articles

FLT3 Is Sumoylated and Localizes to the Nucleus in Acute Myeloid Leukemia

Marisse Asong, MD MSc, Julhash Uddin Kazi, PhD, Lars Ronnstrand, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2733.
https://doi.org/10.1182/blood-2019-127914
Published: 2019
Journal Articles

LIM Domain Protein 1 (Ldb1) Is Required for Lmo2 Oncogene-Induced Thymocyte Self-Renewal and T-Cell Leukemia in a Mouse Model of Human T-ALL

Liqi Li, PhD, Apratim Mitra, Bin Zhao, Seeyoung Choi, Jan Lee, Daniel Stamos, Claude Warzecha, Karl Pfeifer, Joyce Hardwick, Bryan Venters, Paul Love, Utpal Dave, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2538.
https://doi.org/10.1182/blood-2019-127534
Published: 2019