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Journal Articles

EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene

Free
Rajesh Somasundaram, Christina T. Jensen, Johanna Tingvall-Gustafsson, Josefine Åhsberg, Kazuki Okuyama, Mahadesh Prasad, James R. Hagman, Xun Wang, Shamit Soneji, Tobias Strid, Jonas Ungerbäck, Mikael Sigvardsson
Journal: Blood
Blood (2021) 137 (22): 3037–3049.
https://doi.org/10.1182/blood.2020009564
Published: 2021
Includes: Supplemental data
Journal Articles

Dynamic CTCF binding directly mediates interactions among cis -regulatory elements essential for hematopoiesis

Free
Qian Qi, Li Cheng, Xing Tang, Yanghua He, Yichao Li, Tiffany Yee, Dewan Shrestha, Ruopeng Feng, Peng Xu, Xin Zhou, Shondra Pruett-Miller, Ross C. Hardison, Mitchell J. Weiss, Yong Cheng
Journal: Blood
Blood (2021) 137 (10): 1327–1339.
https://doi.org/10.1182/blood.2020005780
Published: 2021
Includes: Supplemental data
Journal Articles

Plasmablasts derive from CD23 – activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction

Free
Amandine Pignarre, Fabrice Chatonnet, Gersende Caron, Marion Haas, Fabienne Desmots, Thierry Fest
Journal: Blood
Blood (2021) 137 (9): 1166–1180.
https://doi.org/10.1182/blood.2020005083
Published: 2021
Includes: Supplemental data
Journal Articles

Mutation of the CD28 Co-Stimulatory Domain Confers Enhanced CAR T Cell Function

Free
Justin C. Boucher, PhD, Gongbo Li, PhD MBBS, Hiroshi Kotani, MD PhD, Maria Cabral, Dylan Morrissey, Sae Bom Lee, Kristen Spitler, Nolan Beatty, Bishwas Shrestha, PhD, Bin Yu, Aslamuzzaman Kazi, Xuefeng Wang, PhD, Said Sebti, PhD, Marco L. Davila, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 248.
https://doi.org/10.1182/blood-2019-122954
Published: 2019
Journal Articles

Chromatin Accessibility Mapping of Primary Erythroid Cell Populations Leads to Identification and Validation of Nuclear Factor I X (NFIX) As a Novel Fetal Hemoglobin (HbF) Repressor

Free
Mudit Chaand, PhD, Chris Fiore, PhD, Brian T Johnston, MS, Diane H Moon, PhD, John P Carulli, PhD, Jeffrey R Shearstone, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 812.
https://doi.org/10.1182/blood-2019-124337
Published: 2019
Journal Articles

Mutations and Copy Number Gains of the BCL2 Family Members Mediate Resistance to Venetoclax in Multiple Myeloma (MM) Patients

Free
Paola Neri, MD PhD, Ranjan Maity, PhD, Jean-Baptiste Alberge, Sarthak Sinha, BSc, Justin Donovan, Madison Kong, Fajer Hasan, Arzina Jaffer, Lawrence H. Boise, PhD, Nizar Bahlis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 572.
https://doi.org/10.1182/blood-2019-127593
Published: 2019
Journal Articles

Mechanistic Basis and Efficacy of Targeting β-Catenin-TCF7L2-JMJD6-MYC Axis to Overcome Resistance to BET Inhibitors

Free
Christopher Peter Mill, PhD BA, Warren Fiskus, BSc,PhD, Dyana T. Saenz, PhD, Bernardo H Lara, Vrajesh Karkhanis, PhD, Taghi Manshouri, PhD, Isean Bhalla, Nancy Shao, James V Maher, Srdan Verstovsek, MD PhD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 538.
https://doi.org/10.1182/blood-2019-125142
Published: 2019
Journal Articles

Integrated Epigenetic Profiling Identifies EZH2 As a Therapeutic Target to Re-Establish Immune Recognition of Leukemia Relapses with Loss of HLA Class II Expression

Free
Valentina Gambacorta, MSc, Daniela Gnani, PhD, Laura Zito, MSc, Stefano Beretta, PhD, Lucia Zanotti, PhD, Oliveira Giacomo, PhD, Davide Cittaro, PhD, Ivan Merelli, PhD, Fabio Ciceri, MD, Raffaella Di Micco, PhD, Luca Vago, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 514.
https://doi.org/10.1182/blood-2019-127395
Published: 2019
Journal Articles

Decline in Insulin-like Growth Factor-1 (IGF1) from Aged Mesenchymal Stromal Cells Is a Targetable Mechanism to Rescue Hematopoietic Stem Cell Aging

Free
Kira Young, PhD, Elizabeth Eudy, BS, Matthew Loberg, BA, Rebecca Bell, BA, Jennifer Trowbridge, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 526.
https://doi.org/10.1182/blood-2019-124534
Published: 2019
Journal Articles

Transcription Factor Induction of Ectopic Vascular Blood Stem Cell Niches In Vivo

Free
Elliott J. Hagedorn, PhD, Julie R. Perlin, PhD, Rebecca J. Freeman, BS, Clara Mao, BS, Inés Fernández-Maestre, BS, Madeleine L. Daily, B.S., Christopher R. D'Amato, B.S., Samuel J. Wattrus, B.S., Tianxiao Han, BS, Michael J. Fairchild, PhD, Raquel Riquelme, Brian Li, B.S., Shelby E. Redfield, B.S., Samantha H. Collins, B.S., Asher Lichtig, BS, Song Yang, PhD, Yi Zhou, Balvir Kunar, Jesus M Gomez-Salinero, PhD, Theresa T. Dinh, PhD, Junliang Pan, MD PhD, Karoline Holler, B.S., Eugene Butcher, Alexander Van Oudenaarden, Shahin Rafii, MD, Jan Philipp Junker, PhD, Leonard I Zon, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 525.
https://doi.org/10.1182/blood-2019-127219
Published: 2019
Journal Articles

Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells

Free
Zhaowei Tu, PhD, Chen Wang, MSc, Chuntao Zhao, PhD, Lei Huang, PhD, Nathan Salomonis, PhD, Richard Q Lu, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1191.
https://doi.org/10.1182/blood-2019-127313
Published: 2019
Journal Articles

MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers

Free
Vivian M. Liu, MD, Romain Guièze, MD, Daniel Rosebrock, Alexis A Jourdain, PhD, María Hernández-Sánchez, PhD, Aina Zurita Martinez, Elisa Ten Hacken, PhD, Philip A. Thompson, MBBS, Julian Bryan Iorgulescu, MD PhD, Shuqiang Li, PhD, Matthew S. Davids, MD, Jennifer R. Brown, MD PhD, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, William G. Wierda, MD PhD, Anthony G. Letai, MD PhD, Donna S Neuberg, ScD, Christopher J. Ott, PhD, Ignaty Leshchiner, PhD, Vamsi Mootha, MD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1284.
https://doi.org/10.1182/blood-2019-131336
Published: 2019
Journal Articles

FLT3 ITD Target Enhancers Are Primed but Inaccessible in Fetal Hematopoietic Progenitors

Free
Yanan Li, PhD, Riddhi M Patel, BS, Emily Casey, Jeffrey A. Magee, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1228.
https://doi.org/10.1182/blood-2019-126201
Published: 2019
Journal Articles

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Free
Yosuke Tanaka, MD, Masahito Kawazu, MD PhD, Satoshi Inoue, PhD, Shinya Kojima, Ueno Toshihide, PhD, Toshiaki Uno, Moe Tamura, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Shinichi Morishita, PhD, Hiroyuki Mano, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1240.
https://doi.org/10.1182/blood-2019-125207
Published: 2019
Journal Articles

Adult Hematopoietic Stem and Progenitor Cell Maintenance Requires Histone Variant H3.3 Regulation By Hira

Free
Rebecca Murdaugh, BS, Kevin Hoegenauer, Xiangguo Shi, PhD, Ayumi Kitano, Richard Chapple, PhD, Tianyuan Hu, PhD, Jonathan Tiessen, BS, Daisuke Nakada, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2473.
https://doi.org/10.1182/blood-2019-131358
Published: 2019
Journal Articles

Genetic Interactions between Cohesin Mutations and Core-Binding Factor Driver Oncogenes

Free
Katelyn E Heimbruch, Sridhar Rao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2540.
https://doi.org/10.1182/blood-2019-125893
Published: 2019
Journal Articles

CK2 Inhibitor CX4945 Shows Strong In Vivo Anti Leukemia Effect in AML Via Augmented Ikaros-Mediated Regulation of Global Epigenetic Landscape

Free
Chandrika Gowda, MBBS, Chunhua Song, MD, Sadie Steffens, PhD, Yali Ding, PhD, Bo Zhang, Feng Yue, PhD, Soumya Iyer, PhD, Pavan kumar Dhanyamraju, PhD, Jonathon Payne, Morgann Reed, BS, Kimberly J. Payne, PhD, Sinisa Dovat, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2522.
https://doi.org/10.1182/blood-2019-131200
Published: 2019
Journal Articles

Role of Mutant p53 in the Progression of Chronic Lymphocytic Leukemia

Free
Janani Ravikrishnan, Tzung-Huei Lai, PhD DVM, Elizabeth Muhowski, Lindsey Brinton, PhD, Katie Williams, MS, Alexandria Thompson, James S. Blachly, MD, Hatice Gulcin Ozer, PhD, John C. Byrd, MD, Rosa Lapalombella, PhD, Jennifer Woyach, MD, Deepa Sampath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2526.
https://doi.org/10.1182/blood-2019-128574
Published: 2019
Journal Articles

PRDM1 Binds an Extensive Network of Genes to Regulate Human Natural Killer Cell Homeostasis

Free
Xuxiang Liu, PhD, Yunfei Shi, MD PhD, Yuping Li, PhD, Ru Chen, PhD, Sheng Pan, PhD, Gehong Dong, MD PhD, Qiang Gong, PhD, Javeed Iqbal, PhD, Haiqing Li, PhD, Jinhui Wang, PhD, Shuhua Yi, MD, Timothy McKeithan, MD PhD, Wing C. Chan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2536.
https://doi.org/10.1182/blood-2019-129270
Published: 2019
Journal Articles

Detailed Multi-Method Analysis of Bone Marrow from Pediatric Pre-B-ALL Patients Prior to CD19-CAR-T Therapy Subsequently Evidencing Overt CAR-T Resistance

Free
Katherine Elizabeth Masih, BS, Rebecca Gardner, MD, Berkley Gryder, PhD, Abdelmaksoud Abdallah, BS, Justin Lack, PhD, Benjamin Stanton, PhD, Ashley Wilson, PhD, Sivasish Sindiri, MS, Young Song, PhD, Zachary Rae, BS, Michael Kelly, PhD, Wang Chaoyu, MS, Xinyu Wen, MS, Adam Cheuk, PhD, Jun Wei, PhD, Michael C. Jensen, MD, Javed Khan, MD, Rimas Orentas, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2744.
https://doi.org/10.1182/blood-2019-130796
Published: 2019