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Journal Articles

Blinatumomab-Induced T Cell Activation at Single Cell Transcriptome Resolution

Free
Hong Yin, MD PhD, Yi Huo, PhD, Zhen Sheng, PhD, Chi-Ming Li, PhD, Daniel C Ellwanger, PhD, Daniel Lu, PhD, Oliver Homann, PhD, Songli Wang, MD PhD, Ruibao Ren, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3886.
https://doi.org/10.1182/blood-2019-124636
Published: 2019
Journal Articles

Targeted Marrow Radiation (TMI) Improves Therapeutic Efficacy of STAT3 Decoy Molecules By Augmenting Its Delivery and Immune Modulation in an AML Mouse Model

Free
Srideshikan Sargur Madabushi, PhD, Darren Zuro, Yu-Lin SU, PhD, Paresh Vishwasrao, MSc, Jamison Brooks, B.S, Liliana E Parra, James F Sanchez, PhD, Jeffrey Wong, MD, Marcin Kortylewski, PhD, Susanta Hui, PhD, DABR.
Journal: Blood
Blood (2019) 134 (Supplement_1): 3929.
https://doi.org/10.1182/blood-2019-127470
Published: 2019
Journal Articles

Myeloid-Derived Suppressor Cells As Potential Contributors to Pregnancy-Associated Lymphoma Progression

Free
Netanel A Horowitz, MD, Noam Bettman, PhD, Ali Abd El Wahed, Tamar Katz, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3979.
https://doi.org/10.1182/blood-2019-124292
Published: 2019
Journal Articles

First in Human Study of SEL24/MEN1703, First in Class, Orally Available Dual PIM/FLT3 Kinase Inhibitor, in Patients with Acute Myeloid Leukemia

Free
Scott R. Solomon, MD, Aziz Nazha, MD, Stephen A. Strickland, MD, Roland B. Walter, MD PhD MS, Ilaria Valimberti, Alessia Tagliavini, Paolo Mazzei, Caterina Fiesoli, Simona Scartoni, Daniela Bellarosa, Monica Binaschi, PhD, Pawel Chrom, MD PhD, Simone Baldini, MD, Krzysztof Brzózka, PhD, Angela Capriati, Andrea Pellacani, PhD MD, Farhad Ravandi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3920.
https://doi.org/10.1182/blood-2019-125878
Published: 2019
Journal Articles

Mesenchymal Stem Cells Improve the Structure and Function of the Graft-Versus-Host Disease Receptor Thymus: CCR9 Plays an Important Role in Its Homing Thymus

Free
Xin Zhang, Ke Zhao, MD, Jiabao He, Andy Peng Xiang, PhD, Qifa Liu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5599.
https://doi.org/10.1182/blood-2019-125307
Published: 2019
Journal Articles

Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia (CMML)

Free
Gregor Eisenwort, MD PhD, Alexandra Keller, Michael Willmann, Irina Sadovnik, Greiner Georg, MD PhD, Karoline V. Gleixner, MD, Daniel Ivanov, MSc, Daniela Berger, Gabriele Stefanzl, Christiana Winding, DVM, Gregor Hoermann, Wolfgang R. Sperr, MD, Heinz Sill, MD, Peter Bettelheim, MD, Klaus Geissler, MD, Michael W. Deininger, Thomas Rülicke, Peter Valent, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4223.
https://doi.org/10.1182/blood-2019-122530
Published: 2019
Journal Articles

Genomic Profiles and Subset Characterization of CD8 + terminally Differentiated Effector Memory (T EMRA ) Cells from Cancer Patients

Free
Deok-Hwan Yang, MD PhD, Jae-Sook Ahn, Seo-Yeon Ahn, MD, Sung-Hoon Jung, MD, Je-Jung Lee, MD PhD, Hyeoung-Joon Kim, MD PhD, Young Rok Do, PhDMD, Sang Yun Song, MD PhD, Ga-Young Song, Hyeong Jong Kim, MD, Theresa Kim
Journal: Blood
Blood (2019) 134 (Supplement_1): 2329.
https://doi.org/10.1182/blood-2019-126533
Published: 2019
Journal Articles

Single Cell Signaling Responses Stratify Immune and Leukemia Cell Populations in Acute Myeloid Leukemia

Free
Kathryn I Sunthankar, MD, Benjamin J Reisman, BS, Candace H Cote, BS, Paul Brent Ferrell, Jr., MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2680.
https://doi.org/10.1182/blood-2019-129602
Published: 2019
Journal Articles

T Cells Educated By DC/AML Fusions in the Context of 4-1BB Costimulation As a Potent Strategy for Adoptive Cellular Therapy

Free
Jessica Liegel, MD, Dina Stroopinsky, PhD, Haider Ghiasuddin, Adam Morin, Marzia Capelletti, PhD MMSc, Shira Orr, PhD, Maryam Rahimian, MD, Lina Bisharat, Shufen Meng, MD, Myrna Nahas, MD, Matthew Weinstock, MD, Donald Kufe, MD, Jacalyn Rosenblatt, MD, David E. Avigan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2673.
https://doi.org/10.1182/blood-2019-131491
Published: 2019
Journal Articles

Altered Immunophenotypes on Leukemic and/or Monocytic Cells from Acute Myeloid Leukemia Highly Predict for Nucleophosmin Gene Mutation

Free
Sergio Matarraz, Pilar Leoz, Xavier Calvo, MD PhD, Luis García Alonso, Rosa Ayala Bueno, José Ignacio Sánchez-Gallego, PhD, Neus Villamor, Enrique Colado, MD PhD, María Belén Vidriales, María Isabel Prieto Conde, Maria Carmen Chillon, Ramón García-Sanz, MD PhD, Vincent H.J. Van Der Velden, PhD, Félix López Cadenas, MD, María Díez-Campelo, MD PhD, Leonor Arenillas, MD PhD, Sara Alonso, MD, Ariana Fonseca, Covadonga Quirós Caso, Laura Magnano, José Antonio Garcia Vela, MD, Carlos Fernandez, Daniela Damasceno, Andrea Mayado, Susana Barrena, PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2687.
https://doi.org/10.1182/blood-2019-131733
Published: 2019
Journal Articles

Cross Talk between the Immune Compartment and the Tumor Cells in Myelodysplastic Syndromes (MDS)

Free
Camille Bigenwald, MD, Amir Horowitz, PhD, Shyamala C. Navada, MD, Rosalie Odchimar-Reissig, RN, Richa Rai, PhD, Stella Melana, PhD, Erin P. Demakos, RN, Miriam Merad, MD, Lewis R. Silverman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2986.
https://doi.org/10.1182/blood-2019-124887
Published: 2019
Journal Articles

Latent Membrane Protein 1 Contributes to Deficient Cellular Immunity in NKTCL Patients

Free
Xiaoyan Feng, Yue Song, Zhaoming Li, MD PhD, Xudong Zhang, Lugui Qiu, MD PhD, Mingzhi Zhang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3969.
https://doi.org/10.1182/blood-2019-128622
Published: 2019
Journal Articles

Duobody-CD3xCD20 Induces Potent Anti-Tumor Activity in Malignant Lymph Node B Cells from Patients with DLBCL, FL and MCL Ex Vivo , Irrespective of Prior Treatment with CD20 Monoclonal Antibodies

Free
Hilma J Van Der Horst, MSc, A. Vera de Jonge, Ida H Hiemstra, PhD, Anne T Gelderloos, MSc, Daniella RAI Berry, Nathalie J Hijmering, Daphne de Jong, Prof Dr, Martine E.D. Chamuleau, Sonja Zweegman, MD PhD, Esther CW Breij, DPhil, Margaretha GM Roemer, PhD, Tuna Mutis
Journal: Blood
Blood (2019) 134 (Supplement_1): 4066.
https://doi.org/10.1182/blood-2019-125765
Published: 2019
Journal Articles

TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion

Free
Harbani Malik, PhD, Ben Buelow, MD PhD, Udaya Rangaswamy, PhD, Aarti Balasubramani, Andrew Boudreau, Kevin Dang, Laura Davison, PhD, Shelley Force Aldred, Katherine Marie Harris, MD, Suhasini Iyer, PhD, Brett Jorgensen, PhD, Duy Pham, MBA, Kirthana Prabhakar, Ute Schellenberger, PhD, Harshad Ugamraj, Nathan Trinklein, PhD, Wim Van Schooten, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4070.
https://doi.org/10.1182/blood-2019-123226
Published: 2019
Journal Articles

The Lymphoma Tumor Microenvironment Influences Toxicity after CD19 CAR T Cell Therapy

Free
Michael D. Jain, MD PhD, Rawan Faramand, MD, Verena Staedtke, MD PhD, Renyuan Bai, MBBS, Sae Bom Lee, Hiroshi Kotani, MD PhD, Kayla Reid, Kristen Spitler, Julio Chavez, Bijal Shah, MD, Christina A Bachmeier, PharmD, Marian Dam, ARNP, Brigett Brandjes, PA, Ricardo J Gonzalez, MD, John E Mullinax, MD PhD, Xuefeng Wang, PhD, Mohammad Hussaini, MD, Frederick L. Locke, MD, Marco L. Davila, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4105.
https://doi.org/10.1182/blood-2019-127305
Published: 2019
Journal Articles

Phase 2 Study of E7777, a Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein, in Japanese Patients with Relapsed or Refractory Peripheral and Cutaneous T-Cell Lymphoma

Free
Dai Maruyama, MD PhD, Kiyoshi Ando, Kazuhito Yamamoto, Eiji Kiyohara, MD, Yasuhito Terui, MD PhD, Noriko Fukuhara, MD PhD, Tomomitsu Miyagaki, MD PhD, Hidetsugu Kawai, MD, Yoshiki Tokura, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Tadahiko Igarashi, MD PhD, Junya Kuroda, MD PhD, Jiro Fujita, MD PhD, Toshiki Uchida, MD PhD, Takayuki Ishikawa, MD PhD, Kentaro Yonekura, MD PhD, Koji Kato, MD PhD, Tadashi Nakanishi, Kenya Nakai, Risa Matsunaga, Kensei Tobinai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4032.
https://doi.org/10.1182/blood-2019-121723
Published: 2019
Journal Articles

Immune Monitoring of CD34+ Placental Cell Derived Natural Killer Cell Therapy (PNK-007) in Phase I Study of Multiple Myeloma

Free
William Van Der Touw, Lin Kang, PhD, Joseph Dennis Tario, PhD, Bhavani Stout, Vanessa Voskinarian-Berse, Valentina Rousseva, Paul K. Wallace, MS, PhD, Robert Hariri, MD PhD, Xiaokui Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4457.
https://doi.org/10.1182/blood-2019-124509
Published: 2019
Journal Articles

Neddylation Pathway Regulates Treg Differentiation and T Cell Function in Chronic Lymphocytic Leukemia (CLL) Ex Vivo and Murine In Vivo Studies

Free
Scott R Best, BS, Vi Lam, Nur Bruss, BS, Taylor Hashiguchi Rowland, BS, Adam S. Kittai, MD, Tingting Liu, Allison J Berger, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4313.
https://doi.org/10.1182/blood-2019-123600
Published: 2019
Journal Articles

Allogeneic Cord Blood Regulatory T Cells Can Prevent Graft Vs. Host Disease and Preserve Graft Vs Leukemia Effect: Update on Phase I/II Clinical Trial

Free
Ke Zeng, MD PhD, Hongbing Ma, MD PhD, Uday Popat, MD, Yago Nieto, MD PhD, Stefan O. Ciurea, MD, Amanda L. Olson, MD, Mi-Ae Lyu, PhD, Meixian Huang, Mitsutaka Nishimoto, MD PhD, Muzaffar H. Qazilbash, MD, Jennifer D Ramos, RN, Elizabeth J. Shpall, MD, Richard E. Champlin, MD, Simrit Parmar, MBBS, Borje S Andersson, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4547.
https://doi.org/10.1182/blood-2019-127726
Published: 2019
Journal Articles

Anti-CD6 Monoclonal Antibody Itolizumab Efficiently Inhibits T Cell Proliferation after in Vitro TCR Stimulation in the Setting of Acute Graft Versus Host Disease

Free
Benedetta Rambaldi, MD, Carol Reynolds, PhD, Sharmila Chamling Rai, BSc, Takeru Asano, MD PhD, Yohei Arihara, MD PhD, Mahasweta Gooptu, MD, John Koreth, MBBS, DPhil, Corey Cutler, MD MPH, FRCPC, Sarah Nikiforow, MD PhD, Vincent T. Ho, MD, Edwin P. Alyea, III, MD, Joseph H. Antin, MD, Rizwan Romee, MD PhD, Robert J. Soiffer, MD, Domenico Russo, MD, Jeanette Ampudia, BSc, Cherie Tracy Ng, PhD MPH, Stephen Connelly, PhD MBA, Jerome Ritz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4517.
https://doi.org/10.1182/blood-2019-125721
Published: 2019