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Journal Articles

FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

Blood (2019) 134 (Supplement_1): 4434.

https://doi.org/10.1182/blood-2019-130584

Published: 2019

Journal Articles

CD4 + T Cells Sustain Aggressive Chronic Lymphocytic Leukemia through a CD40L-Independent Mechanism

Matteo Bellone, MD, Paolo Dellabona, MD PhD, Arianna Calcinotto, BS, Giulia Casorati, PhD, Alessandra Rovida, PhD, Maria Teresa Sabrina Bertilaccio, PhD, Elena Cattaneo, Matteo Grioni, Federico caligaris-Cappio, Paolo Ghia, MD PhD

Blood (2019) 134 (Supplement_1): 683.

https://doi.org/10.1182/blood-2019-128246

Published: 2019

Journal Articles

A Unique Crosstalk between Tumor Cells and Hematopoietic Stem Cells Reveals a Myeloid Differentiation Pattern Signature Contributing to Metastasis

Ksenia Magidey, PhD, Ksenya Kveler, PhD, Rachelly Normand, PhD, Tongwu Zhang, PhD, Michael Timaner, PhD, Ziv Raviv, PhD, Brian James, PhD, Roi Gazit, PhD, Ze'ev Ronai, PhD, Shai Shen-Orr, PhD, Yuval Shaked, PhD

Blood (2019) 134 (Supplement_1): 2465.

https://doi.org/10.1182/blood-2019-128126

Published: 2019

Journal Articles

T-Cell Reconstitution after Unrelated Donor HSCT Using Immunotherapy with CD25/71 Allodepleted Donor T Cells: Results of the Randomised Icat Study

Blood (2019) 134 (Supplement_1): 1995.

https://doi.org/10.1182/blood-2019-124404

Published: 2019

Journal Articles

The Lymphoma Tumor Microenvironment Influences Toxicity after CD19 CAR T Cell Therapy

Michael D. Jain, MD PhD, Rawan Faramand, MD, Verena Staedtke, MD PhD, Renyuan Bai, MBBS, Sae Bom Lee, Hiroshi Kotani, MD PhD, Kayla Reid, Kristen Spitler, Julio Chavez, Bijal Shah, MD, Christina A Bachmeier, PharmD, Marian Dam, ARNP, Brigett Brandjes, PA, Ricardo J Gonzalez, MD, John E Mullinax, MD PhD, Xuefeng Wang, PhD, Mohammad Hussaini, MD, Frederick L. Locke, MD, Marco L. Davila, MD PhD

Blood (2019) 134 (Supplement_1): 4105.

https://doi.org/10.1182/blood-2019-127305

Published: 2019

Journal Articles

CD47 Regulates Red Blood Cell Alloimmunization in Mice

Ryan Jajosky, MD, Connie Arthur, PhD, Jerry Allen, BS, Megan Fuller, BS, Patricia E Zerra, MD, Cheryl Maier, MD PhD, Sean R. Stowell, MD PhD

Blood (2019) 134 (Supplement_1): 100.

https://doi.org/10.1182/blood-2019-131598

Published: 2019

Journal Articles

Multiple Pathways Targeting CD25 or TNFRSF25 Affect CD4 + FoxP3 + Regulatory T Cell Phenotype and Suppressive Function

Sabrina N. Copsel, PhD, Henry Barreras, MPH, Casey O. Lightbourn, BS, MS, Cameron S. Bader, BS, Dietlinde Wolf, PhD, Brandon Kale, Warren Alperstein, MD, Krishna V Komanduri, MD, Robert B. Levy, PhD

Blood (2019) 134 (Supplement_1): 4430.

https://doi.org/10.1182/blood-2019-130649

Published: 2019

Journal Articles

Treatment with Acalibrutinib, Ibrutinib and CD19 CAR T Cells Restore the Number of Granulocytic Myeloid Derived Supressor Cells in CLL-Bearing Mice

Arantxa Romero-Toledo, MSc, Robin Sanderson, MRCP,FRCPath, John G. Gribben, MD DSc

Blood (2019) 134 (Supplement_1): 3032.

https://doi.org/10.1182/blood-2019-126697

Published: 2019

Journal Articles

In Vitro and in Vivo Activity of Melflufen in Amyloidosis

Ken Flanagan, PhD, Muntasir M Majumder, MSc, BPharm, Romika Kumari, PhD, Juho Miettinen, PhD, Ana Slipicevic, PhD, Sarah A. Holstein, MD PhD, Michelle L. Varney, MS, Minna Suvela, MSC, Fredrik Lehmann, PhD, Nina N. Nupponen, PhD, Caroline A Heckman, PhD

Blood (2019) 134 (Supplement_1): 3100.

https://doi.org/10.1182/blood-2019-125952

Published: 2019

Journal Articles

Adoptively Transferred Donor-Derived Cytokine Induced Memory-like NK Cells Persist and Induce Remission in Pediatric Patient with Relapsed Acute Myeloid Leukemia after Hematopoietic Cell Transplantation

Jeffrey J. Bednarski, MD PhD, Clare Zimmerman, MD, Amanda F Cashen, MD, Sweta Desai, Mark Foster, Tim Schappe, BS, Ethan McClain, Michelle Becker-Hapak, BS, Melissa M Berrien-Elliott, PhD, Todd A Fehniger, MD PhD

Blood (2019) 134 (Supplement_1): 3307.

https://doi.org/10.1182/blood-2019-126982

Published: 2019

Journal Articles

Off-Target HLA Cross-Reactivity By (Third Party) Virus-Specific T Cells Is Surprisingly Affected By HLA Restriction and HLA Background but Not By Virus Specificity

Wesley Huisman, MSc, Didier A.T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, PhD, Fred Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2019) 134 (Supplement_1): 4440.

https://doi.org/10.1182/blood-2019-124785

Published: 2019

Journal Articles

Activation of Regulatory T Cells with IL-2 and TNF-α to Promote Homing to the Gut and to Improve Acute GvHD Prevention

Antonella Mancusi, PhD, Samanta Bonato, MD, Rachele Del Sordo, MD, Sara Piccinelli, Eni Hoxha, Tiziana Zei, Roberta Iacucci Ostini, Franca Falzetti, MD, Alessandra Carotti, MD, Loredana Ruggeri, MD, Michele Giansanti, MD, Robert S. Negrin, MD, Massimo Fabrizio Martelli, MD, Andrea Velardi, MD, Antonio Pierini, MD PhD

Blood (2019) 134 (Supplement_1): 4447.

https://doi.org/10.1182/blood-2019-123202

Published: 2019

Journal Articles

The First Functional HLA-a*01:01-Restricted EBV-LMP2-Specific T-Cell Receptors for TCR Gene Therapy of Patients with EBV-Associated Type II/III Malignancies

Wesley Huisman, MSc, Ilse Gille, Lieve E. van der Maarel, Lois Hageman, Rob C.M. de Jong, PhD, Derk Amsen, PhD, Fred Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2019) 134 (Supplement_1): 4448.

https://doi.org/10.1182/blood-2019-123736

Published: 2019

Journal Articles

Investigation of Allocar T TM Targeting CD70 As a Potential Therapy for an Array of Hematological Malignancies

Siler Panowski, PhD, Surabhi Srinivasan, MS, Thomas Van Blarcom, PhD, Cesar Sommer, PhD, Hsin-Yuan Cheng, PhD, Thomas Pertel, PhD, Marianne A Santaguida, PhD, Roman Galetto, PhD, Alan Dunlop, BSc, MSc, Reuben Benjamin, MD, Barbra Sasu, PhD

Blood (2019) 134 (Supplement_1): 5157.

https://doi.org/10.1182/blood-2019-128808

Published: 2019

Journal Articles

MYC Oncogene Abrogates Natural Killer (NK) Cell-Mediated Immune Surveillance of B- and T- Lymphoid Malignancies By Suppressing STAT1/2-Type I IFN Signaling

Srividya Swaminathan, PhD, Line Dam Heftdal, MD, Daniel Liefwalker, PhD, Renumathy Dhanasekaran, MD, Anja Deutzmann, PhD, Crista Horton, BS, Adriane Mosley, BS, Mariola Liebersbach, BS, Andrew Gentles, PhD, Holden T. Maecker, PhD, Dean Felsher, MD PhD

Blood (2019) 134 (Supplement_1): 730.

https://doi.org/10.1182/blood-2019-122607

Published: 2019

Journal Articles

Results of a Phase 1 Trial of Gda-201, Nicotinamide-Expanded Allogeneic Natural Killer Cells (NAM-NK) in Patients with Refractory Non-Hodgkin Lymphoma (NHL) and Multiple Myeloma (MM)

Veronika Bachanova, MD PhD, David H. McKenna, MD, Xianghua Luo, PhD, Todd E. DeFor, MS, Fiona He, MD, Murali Janakiram, MD MS, Erica D. Warlick, MD, Rose Wangen, Zuzan Cayci, MD, Bartosz Grzywacz, MD, Guy Brachya, PhD, Tony Peled, MSc, Jeffrey S. Miller, MD

Blood (2019) 134 (Supplement_1): 777.

https://doi.org/10.1182/blood-2019-130476

Published: 2019

Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Blood (2019) 134 (Supplement_1): 473.

https://doi.org/10.1182/blood-2019-127122

Published: 2019

Journal Articles

Thymus Regeneration Is Dependent on Distinct Mesenchymal Stromal Cell Populations

Karin Gustafsson, PhD, Nikolas Barkas, PhD, Ninib Baryawno, PhD, Elizabeth W Scadden, Nicolas Severe, PhD, Joel A Spencer, PhD, Hayalneh Gessessew, Kameron Kooshesh, Jimin Guo, PhD, Charles Lin, PhD, Peter Kharchenko, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 586.

https://doi.org/10.1182/blood-2019-126708

Published: 2019

Journal Articles

Versican Proteolytic Fragments (Matrikines) Regulate the Intratumoral Dendritic Cell Milieu In Vivo: Implications for in Situ Tumor Vaccination

Athanasios Papadas, MD, Evan Flietner, BS, Zachary Morrow, BS, Joshua Wiesner, Alexander Cicala, Adam Pagenkopf, BS, Chelsea L. Hope, PhD, Adhithi Rajagopalan, BS, Zhi Wen, PhD, Philip Emmerich, Dustin Deming, Shigeki Miyamoto, PhD, Peiman Hematti, MD, Natalie Scott Callander, MD, Alexander Rakhmilevich, Mario Otto, MD PhD, Christian M. Capitini, MD, Jing Zhang, PhD, Fotis Asimakopoulos, PhDMBBChir,

Blood (2019) 134 (Supplement_1): 1210.

https://doi.org/10.1182/blood-2019-131582

Published: 2019

Journal Articles

Enhancing Anti-Tumor Immunity and Responses to Immune Checkpoint Blockade By Suppressing Interleukin-10 in Chronic Lymphocytic Leukemia

Jacqueline R. Rivas, PhDBS, Sara S. Alhakeem, PhD, Joseph M. Eckenrode, PhD, Yinan Zhang, PhD, James P. Collard, BS, Gerhard C. Hildebrandt, MD, Roger A. Fleischman, MD PhD, Li Chen, PhD, Jon S. Thorson, PhD, Markos Leggas, PhD, Subbarao Bondada, PhD

Blood (2019) 134 (Supplement_1): 5486.

https://doi.org/10.1182/blood-2019-127178

Published: 2019

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FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

CD4 + T Cells Sustain Aggressive Chronic Lymphocytic Leukemia through a CD40L-Independent Mechanism

A Unique Crosstalk between Tumor Cells and Hematopoietic Stem Cells Reveals a Myeloid Differentiation Pattern Signature Contributing to Metastasis

T-Cell Reconstitution after Unrelated Donor HSCT Using Immunotherapy with CD25/71 Allodepleted Donor T Cells: Results of the Randomised Icat Study

The Lymphoma Tumor Microenvironment Influences Toxicity after CD19 CAR T Cell Therapy

CD47 Regulates Red Blood Cell Alloimmunization in Mice

Multiple Pathways Targeting CD25 or TNFRSF25 Affect CD4 + FoxP3 + Regulatory T Cell Phenotype and Suppressive Function

Treatment with Acalibrutinib, Ibrutinib and CD19 CAR T Cells Restore the Number of Granulocytic Myeloid Derived Supressor Cells in CLL-Bearing Mice

In Vitro and in Vivo Activity of Melflufen in Amyloidosis

Adoptively Transferred Donor-Derived Cytokine Induced Memory-like NK Cells Persist and Induce Remission in Pediatric Patient with Relapsed Acute Myeloid Leukemia after Hematopoietic Cell Transplantation

Off-Target HLA Cross-Reactivity By (Third Party) Virus-Specific T Cells Is Surprisingly Affected By HLA Restriction and HLA Background but Not By Virus Specificity

Activation of Regulatory T Cells with IL-2 and TNF-α to Promote Homing to the Gut and to Improve Acute GvHD Prevention

The First Functional HLA-a*01:01-Restricted EBV-LMP2-Specific T-Cell Receptors for TCR Gene Therapy of Patients with EBV-Associated Type II/III Malignancies

Investigation of Allocar T TM Targeting CD70 As a Potential Therapy for an Array of Hematological Malignancies

MYC Oncogene Abrogates Natural Killer (NK) Cell-Mediated Immune Surveillance of B- and T- Lymphoid Malignancies By Suppressing STAT1/2-Type I IFN Signaling

Results of a Phase 1 Trial of Gda-201, Nicotinamide-Expanded Allogeneic Natural Killer Cells (NAM-NK) in Patients with Refractory Non-Hodgkin Lymphoma (NHL) and Multiple Myeloma (MM)

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Thymus Regeneration Is Dependent on Distinct Mesenchymal Stromal Cell Populations

Versican Proteolytic Fragments (Matrikines) Regulate the Intratumoral Dendritic Cell Milieu In Vivo: Implications for in Situ Tumor Vaccination

Enhancing Anti-Tumor Immunity and Responses to Immune Checkpoint Blockade By Suppressing Interleukin-10 in Chronic Lymphocytic Leukemia

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