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Journal Articles

Paroxysmal Nocturnal Hemoglobinuria Clones Are Infrequent in Hepatitis-Associated Aplastic Anemia at the Time of Diagnosis

Wenrui Yang, MD, Xin Zhao, MD PhD, Guangxin Peng, MD, Li Zhang, MD, Liping Jing, MD, Kang Zhou, MD, Yang Li, MD, Lei Ye, MD, Yuan Li, MD, Jianping Li, MD, Huihui Fan, MD, Lin Song, MD, Yang Yang, MD, Youzhen Xiong, MD, Fengkui Zhang, MD, Jianxiang Wang, MD

Blood (2019) 134 (Supplement_1): 5016.

https://doi.org/10.1182/blood-2019-125620

Published: 2019

Journal Articles

Single-Cell RNA Sequencing of Healthy Human Marrow Hematopoietic Cells

Xin Zhao, MD PhD, Shouguo Gao, PhD, Sachiko Kajigaya, PhD, Qingguo Liu, MD PhD, Zhijie Wu, MD, Xingmin Feng, PhD, Fengkui Zhang, MD, Neal S. Young, MD

Blood (2019) 134 (Supplement_1): 4997.

https://doi.org/10.1182/blood-2019-123249

Published: 2019

Journal Articles

Crispr/Cas9-Mediated ASXL1 knockout in U937 Human Leukemic Cells Perturbs Myeloid Differentiation

Zhijie Wu, MD, Xin Zhao, MD PhD, Lauren G. Banaszak, BS, Keyvan Keyvanfar, BS, Sachiko Kajigaya, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 1529.

https://doi.org/10.1182/blood.V128.22.1529.1529

Published: 2016

Journal Articles

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

Lauren G. Banaszak, BS, Valentina Giudice, MD, Xin Zhao, MD PhD, Zhijie Wu, MD, Kohei Hosokawa, MD PhD, Keyvan Keyvanfar, BS, Danielle Townsley, MD, Sachiko Kajigaya, PhD, Neal S. Young

Blood (2016) 128 (22): 2704.

https://doi.org/10.1182/blood.V128.22.2704.2704

Published: 2016

Journal Articles

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Xin Zhao, MD PhD, Shouguo Gao, PhD, Xingmin Feng, PhD, Delong Liu, PhD, Sachiko Kajigaya, PhD, Zhijie Wu, MD, Qingguo Liu, MD, Keyvan Keyvanfar, BS, Marie J. Desierto, BS, Danielle M. Townsley, MD, Xujing Wang, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 574.

https://doi.org/10.1182/blood.V128.22.574.574

Published: 2016

Journal Articles

Persistent Elevation of Plasma Thrombopoietin Levels in Severe Aplastic Anemia, Even with Hematologic Recovery

Xin Zhao, MD PhD, Xingmin Feng, PhD, Danielle M. Townsley, MD, Thomas Winkler, MD, Ronan Desmond, MD, Matthew J. Olnes, MD PhD, Harshraj Leuva, Bogdan Dumitriu, MD, Cynthia E. Dunbar, MD, Neal S. Young, MD

Blood (2015) 126 (23): 3609.

https://doi.org/10.1182/blood.V126.23.3609.3609

Published: 2015

Journal Articles

Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status

Caroline R Cantilena, BA, Xin Zhao, MD PhD, Sachiko Kajigaya, PhD, Neil Dunavin, MD, Xin Tian, PhD, Stephen A. Strickland, MD, Bipin N. Savani, MD, Sanjay R. Mohan, MD, Katayoun Rezvani, MDPhD, Xingmin Feng, PhD, Danielle M. Townsley, MD, Minoo Battiwalla, MDMS, Sawa Ito, MD, Austin John Barrett, MDFRCP,FRCPath

Blood (2015) 126 (23): 1267.

https://doi.org/10.1182/blood.V126.23.1267.1267

Published: 2015

Journal Articles

Proof-Of-Concept Study For Precision Medicine With Chromosome Genomic Array Testing (CGAT) For Drug Sensitivity Screening In Acute Myeloid Leukemia

Min Fang, MD, PhD, Scott McElhone, Xin Zhao, MD, Barry E. Storer, PhD, Su-In Lee, Ph.D., C. Anthony Blau, MD, Vivian G. Oehler, MD, Elihu H. Estey, MD, Frederick R. Appelbaum, MD, Pamela S Becker, MD, PhD

Blood (2013) 122 (21): 2578.

https://doi.org/10.1182/blood.V122.21.2578.2578

Published: 2013

Journal Articles

A Novel Small Molecule E-Selectin Inhibitor GMI-1271 Blocks Adhesion of AML Blasts to E-Selectin and Mobilizes Blood Cells in Nodscid IL2Rgc −/− Mice Engrafted with Human AML

Sylvia Chien, Xin Zhao, MD, Margaret Brown, Akanksha Saxena, BS, John T. Patton, PhD, John L. Magnani, PhD, Pamela S Becker, MD, PhD

Blood (2012) 120 (21): 4092.

https://doi.org/10.1182/blood.V120.21.4092.4092

Published: 2012

Journal Articles

Novel Dual E-Selectin-CXCR4 Inhibitors Mobilize Human Acute Myeloid Leukemia (AML) Cells in the NODscid IL2Rγc−/− Xenograft and Confer Susceptibility to Cytarabine

Sylvia Chien, Xin Zhao, MD, John T. Patton, PhD, Theodore Smith, Arun Sarkar, PhD, John L. Magnani, Frederick R. Appelbaum, MD, Pamela S Becker, MD, PhD

Blood (2011) 118 (21): 579.

https://doi.org/10.1182/blood.V118.21.579.579

Published: 2011

Journal Articles

Characterization of Mesenchymal Stromal Cells (MSCs) Derived From Acute Myeloid Leukemia (AML) Bone Marrow

Soumit K. Basu, MD, PhD, Xin Zhao, MD, Sylvia Chien, Min Fang, MD, PhD, Vivian Oehler, MD, Pamela S Becker, MD, PhD

Blood (2011) 118 (21): 2558.

https://doi.org/10.1182/blood.V118.21.2558.2558

Published: 2011

Journal Articles

The CXCR4 Inhibitor Plerixafor Effectively Mobilizes Primary AML in NODscid IL2Rγc −/− Xenografts and Markedly Reduces but Does Not Eradicate Leukemia in Combination with Cytarabine +/− Clofarabine Chemotherapy

Sylvia Chien, Xin Zhao, MD, Thalia Papayannopoulou, Frederick R. Appelbaum, MD, Pamela S. Becker, MD, PhD

Blood (2011) 118 (21): 1432.

https://doi.org/10.1182/blood.V118.21.1432.1432

Published: 2011

Journal Articles

Towards Defining An Optimal Conditioning Regimen for Stem Cell Gene Therapy In Fanconi Anemia.

Pamela S. Becker, MD, PhD, Jennifer Adair, PhD, Xin Zhao, MD, Sylvia Chien, Martin E Wohlfahrt, PhD, Grant Trobridge, PhD, Brian C Beard, PhD, Hans-Peter Kiem

Blood (2010) 116 (21): 1478.

https://doi.org/10.1182/blood.V116.21.1478.1478

Published: 2010

Journal Articles

Clinical and Functional Relevance of Interactions Between the Bone Marrow Stormal Microenvironment and Primary Human Acute Myeloid Leukemia (AML) Cells

Soumit K. Basu, MD, PhD, Sylvia Chien, Xin Zhao, MD, Kenneth J. Kopecky, PhD, Frederick R. Appelbaum, MD, Thalia Papayannopoulou, MD, DSci, Elihu H. Estey, MD, Pamela S. Becker, MD, PhD

Blood (2010) 116 (21): 2756.

https://doi.org/10.1182/blood.V116.21.2756.2756

Published: 2010

Journal Articles

Adhesion Receptor Expression by Acute Myeloid Leukemia (AML) Bone Marrow Derived or Circulating Blasts and AML Stem Cells: The Key to Overcoming Chemoresistance.

Pamela S. Becker, MD, PhD, Sylvia Chien, Mikhail Roshal, MD, PhD, Brent Wood, MD, PhD, Elihu Estey, MD, Thalia Papayannopoulou, MD, Xin Zhao, MD, Soumit Basu, MD, PhD, Mark McGrath, Kenneth Kopecky, PhD, Frederick R Appelbaum, MD

Blood (2009) 114 (22): 2658.

https://doi.org/10.1182/blood.V114.22.2658.2658

Published: 2009

Journal Articles

Oral Small Molecule Inhibitor of VLA-4 Overcomes Adhesion Mediated Chemotherapy Resistance of Acute Myeloid Leukemia (AML) Blasts in Vitro, without Impairment of Normal Blood Cell Recovery When Combined with Chemotherapy in Vivo

Pamela s. Becker, MD, PhD, Frederick R. Appelbaum, MD, Sylvia Chien, Xin Zhao, MD, Halvard Bonig, MD, Ryuta Mukasa, PhD, Thalia Papayannopoulou, MD

Blood (2008) 112 (11): 858.

https://doi.org/10.1182/blood.V112.11.858.858

Published: 2008

Journal Articles

Correction of Fanconi Anemia Group A in Primary Human and Murine Hematopoietic Progenitors with a Clinical Lentiviral Vector

Jason Taylor, MD, PhD, Grant D Trobridge, PhD, Martin Wohlfahrt, Sylvia Chien, Xin Zhao, MD, Brian C Beard, PhD, Hans-Peter Kiem, MD, Pamela S. Becker, MD, PhD

Blood (2008) 112 (11): 2357.

https://doi.org/10.1182/blood.V112.11.2357.2357

Published: 2008

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Paroxysmal Nocturnal Hemoglobinuria Clones Are Infrequent in Hepatitis-Associated Aplastic Anemia at the Time of Diagnosis

Single-Cell RNA Sequencing of Healthy Human Marrow Hematopoietic Cells

Crispr/Cas9-Mediated ASXL1 knockout in U937 Human Leukemic Cells Perturbs Myeloid Differentiation

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Persistent Elevation of Plasma Thrombopoietin Levels in Severe Aplastic Anemia, Even with Hematologic Recovery

Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status

Proof-Of-Concept Study For Precision Medicine With Chromosome Genomic Array Testing (CGAT) For Drug Sensitivity Screening In Acute Myeloid Leukemia

A Novel Small Molecule E-Selectin Inhibitor GMI-1271 Blocks Adhesion of AML Blasts to E-Selectin and Mobilizes Blood Cells in Nodscid IL2Rgc −/− Mice Engrafted with Human AML

Novel Dual E-Selectin-CXCR4 Inhibitors Mobilize Human Acute Myeloid Leukemia (AML) Cells in the NODscid IL2Rγc−/− Xenograft and Confer Susceptibility to Cytarabine

Characterization of Mesenchymal Stromal Cells (MSCs) Derived From Acute Myeloid Leukemia (AML) Bone Marrow

The CXCR4 Inhibitor Plerixafor Effectively Mobilizes Primary AML in NODscid IL2Rγc −/− Xenografts and Markedly Reduces but Does Not Eradicate Leukemia in Combination with Cytarabine +/− Clofarabine Chemotherapy

Towards Defining An Optimal Conditioning Regimen for Stem Cell Gene Therapy In Fanconi Anemia.

Clinical and Functional Relevance of Interactions Between the Bone Marrow Stormal Microenvironment and Primary Human Acute Myeloid Leukemia (AML) Cells

Adhesion Receptor Expression by Acute Myeloid Leukemia (AML) Bone Marrow Derived or Circulating Blasts and AML Stem Cells: The Key to Overcoming Chemoresistance.

Oral Small Molecule Inhibitor of VLA-4 Overcomes Adhesion Mediated Chemotherapy Resistance of Acute Myeloid Leukemia (AML) Blasts in Vitro, without Impairment of Normal Blood Cell Recovery When Combined with Chemotherapy in Vivo

Correction of Fanconi Anemia Group A in Primary Human and Murine Hematopoietic Progenitors with a Clinical Lentiviral Vector

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