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Journal Articles

Pharmacoproteomics Identifies PLK1 As Vulnerability for Aggressive B-Cell Lymphomas

Blood (2018) 132 (Supplement 1): 2853.

https://doi.org/10.1182/blood-2018-99-118004

Published: 2018

Journal Articles

The Synergistic Effect of Melphalan and XPO1 Inhibition in Pre-Clinical Models of Multiple Myeloma

Yan Cui, MD, Joel G Turner, PhD, Jana L Dawson, BS, Juan A Gomez, BS, Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Erkan Baloglu, PhD, William S. Dalton, PhD MD, Taiga Nishihori, MD, Daniel M Sullivan, MD

Blood (2016) 128 (22): 5662.

https://doi.org/10.1182/blood.V128.22.5662.5662

Published: 2016

Journal Articles

Next Generation XPO1 Inhibitor KPT-8602 for the Treatment of Drug-Resistant Multiple Myeloma

Joel G Turner, PhD, Jana L Dawson, BS, Christopher L Cubitt, PhD, Erkan Baluglo, PhD, Steven Grant, MD, Yun Dai, PhD, Kenneth H Shain, MD PhD, William S. Dalton, PhD MD, Sharon Shacham, William Senapedis, PhD, Daniel M Sullivan, MD

Blood (2015) 126 (23): 1818.

https://doi.org/10.1182/blood.V126.23.1818.1818

Published: 2015

Journal Articles

B Cell Receptor (BCR) Signal Pathways Confer Microenvironment-Mediated Drug Resistance and Are Promising Therapeutic Targets for B Cell Lymphomas

Jiangchuan Tao, Tint Lwin, MD, PhD, Xiaohong Zhao, PhD, Ling Zhang, MD, Lynn Moscinski, MD, Eduardo M. Sotomayor, MD, William S. Dalton, PhD, MD, Jianguo Tao, MD, PhD

Blood (2012) 120 (21): 4918.

https://doi.org/10.1182/blood.V120.21.4918.4918

Published: 2012

Journal Articles

Silencing c-Myc Using Myc Inhibitor JQ1 and EZH2 Inhibitor DZNep Blocks Converging Survival Signals in Aggressive B-Cell Lymphomas

Xiaohong Zhao, PhD, Tint Lwin, MD, PhD, Xinwei Zhang, MD, Andy Huang, Jian Wang, Victor E. Marquez, PhD, Selina Chen-Kiang, PhD, James E Bradner, MD, William S. Dalton, PhD, MD, Eduardo M. Sotomayor, MD, Jianguo Tao, MD, PhD

Blood (2012) 120 (21): 4618.

https://doi.org/10.1182/blood.V120.21.4618.4618

Published: 2012

Journal Articles

Targeting Mir-548m-HDAC6 Axis Circumvents Stroma- Mediated Drug Resistance (CAM-DR) and Clonogenicity in Non-Hodgkin B-Cell Lymphomas

Tint Lwin, MD, PhD, Xiaohong Zhao, PhD, Fengdong Cheng, MD, Xinwei Zhang, MD, Yizhuo Zhang, Andy Huang, Lynn Moscinski, MD, William S. Dalton, PhD, MD, Eduardo M. Sotomayor, MD, Jianguo Tao, MD, PhD

Blood (2012) 120 (21): 5094.

https://doi.org/10.1182/blood.V120.21.5094.5094

Published: 2012

Journal Articles

Outcomes Analysis of Doublets of Novel Agents with Corticosteroids Versus Regimens with 3 or More Agents for Multiple Myeloma (MM): A Retrospective Analysis

Rachid Baz, MD, Amila M Patel, PharmD, Viet Q. Ho, PharmD, BCOP, Kenneth Shain, MD, PhD, Melissa Alsina, MD, Taiga Nishihori, MD, Jose Leonel Ochoa-Bayona, M.D., Daniel Sullivan, MD, Benjamin Djulbegovic, MD, PhD, William S. Dalton, PhD, MD

Blood (2011) 118 (21): 1878.

https://doi.org/10.1182/blood.V118.21.1878.1878

Published: 2011

Journal Articles

Pyk2 Mediates Enhanced STAT3 Phosphorylation Following Collaborative Signaling Between gp130 and beta1 Integrins in Adhered Myeloma and B Cells

Mark B Meads, Ph.D., Liang Nong, M.D., Linda Mathews, William S. Dalton, PhD, MD, Kenneth H. Shain, MD, PhD

Blood (2011) 118 (21): 2895.

https://doi.org/10.1182/blood.V118.21.2895.2895

Published: 2011

Journal Articles

Selected Resistance to Topoisomerase II Inhibitors Correlates with the Over Expression of FANCF In a Fanconi Anemia/BRCA DNA Repair Pathway Independent Manner.

Kenneth H. Shain, MD, PhD, Liang Nong, M.D., Danielle Yarde, Vasco Oliveira, William S. Dalton, PhD, MD

Blood (2010) 116 (21): 3372.

https://doi.org/10.1182/blood.V116.21.3372.3372

Published: 2010

Journal Articles

Characterization of Clonal Pre-B Cell Progenitors of Plasma Cells In Multiple Myeloma

Lia Perez, MD, Kelly Boucher, BA, Nancy Parquet, BS, Melissa Alsina, MD, Rachid Baz, MD, Claudio Anasetti, MD, William S. Dalton, PhD, MD

Blood (2010) 116 (21): 1921.

https://doi.org/10.1182/blood.V116.21.1921.1921

Published: 2010

Journal Articles

Updated Results of the Phase II Study of Pegylated Liposomal Doxorubicin (PLD), Low Dose Dexamethasone (DEX) and Lenalidomide (LEN) In Patients with Newly Diagnosed (ND) Multiple Myeloma (MM)

Rachid Baz, MD, Mohamad A Hussein, MD, Daniel Sullivan, MD, Jose-Leonel Ochoa-Bayona, M.D., Monique A Hartley, MD, Kenneth Shain, MD, PhD, Taiga Nishihori, MD, Jennifer Paleveda, Kara Kosakowski, William S. Dalton, PhD, MD, Melissa Alsina, MD

Blood (2010) 116 (21): 3054.

https://doi.org/10.1182/blood.V116.21.3054.3054

Published: 2010

Journal Articles

Myc Represses miR15a/Mir-16-1 Expression through Recruitment of HDAC3 In Mantle Cell Lymphoma

Xinwei Zhang, MD, Xia Chen, MD, Jianhong Lin, MD, Tint Lwin, MD, PhD, Scott A Ely, MD, Selina Chen-Kiang, MD, William S. Dalton, PhD, MD, Edward Seto, PhD, Kenneth Wright, PhD, Eduardo M. Sotomayor, MD, Jianguo Tao, MD, PhD

Blood (2010) 116 (21): 3121.

https://doi.org/10.1182/blood.V116.21.3121.3121

Published: 2010

Journal Articles

Treatments and Outcomes of Patients with Multiple Myeloma (MM) Older Than 75 Years of Age: A Single Institution Experience

Elizabeth Finley-Oliver, RN, Kenneth Shain, MD, PhD, Taiga Nishihori, MD, Jose-Leonel Ochoa-Bayona, M.D., Melissa Alsina, MD, Daniel Sullivan, MD, William S. Dalton, PhD, MD, Rachid Baz, MD

Blood (2010) 116 (21): 4756.

https://doi.org/10.1182/blood.V116.21.4756.4756

Published: 2010

Journal Articles

Microenvironment-Mediated Regulation of Micrornas In B-Lymphocytes as a Novel Mechanism for Terminal B-Cell Differentiation and Lymphomagenesis.

Jianhong Lin, M.D, Tint Lwin, MD, PhD, Wayne Tam, MD, PhD, Jian-Jun Zhao, Luis Crespo, Yong Sung Choi, Xinwei Zhang, Victoria Tannenbaum, Eduardo M. Sotomayor, MD, Lynn C. Moscinski, MD, William S. Dalton, PhD, MD, Ken Wright, PhD, Jianguo Tao, MD, PhD

Blood (2010) 116 (21): 3853.

https://doi.org/10.1182/blood.V116.21.3853.3853

Published: 2010

Journal Articles

MiR-29 MicroRNAs Regulate IGF-1R Expression and Contribute Mantle Cell Lymphoma Growth and Survival.

Jianhong Lin, MD, Jianjun Zhao, MD, Tint Lwin, MD, PhD, Crespo Luis, BS, Fangxia Guan, MD, Sophie Dessureault, MD, PhD, Lynn C. Moscinski, MD, William S. Dalton, PhD, MD, Eduardo M. Sotomayor, MD, Jin Cheng, Jianguo Tao, MD, PhD

Blood (2009) 114 (22): 1957.

https://doi.org/10.1182/blood.V114.22.1957.1957

Published: 2009

Journal Articles

A Novel Upregulation of Fanconi Anemia/BRCA DNA Repair Pathway Is Observed Upon Co-Culture of Bone Marrow Stroma with Multiple Myeloma Cell Lines: A Potential New Participant(s) in Environment Mediated Drug Resistance.

Kenneth H Shain, MD, PhD, Vasco Oliveira, PhD, Danielle Yarde, Linda Mathews, BS, William S. Dalton, PhD, MD

Blood (2009) 114 (22): 2798.

https://doi.org/10.1182/blood.V114.22.2798.2798

Published: 2009

Journal Articles

Bortezomib Reverts Stroma-Mediated Resistant to APO2L/TRAIL in Multiple Myeloma.

Nancy Parquet, BS, Mark Mead, Ph.D., Claudio Anasetti, MD, William S. Dalton, PhD, MD, Lia Perez, MD

Blood (2009) 114 (22): 2806.

https://doi.org/10.1182/blood.V114.22.2806.2806

Published: 2009

Journal Articles

Follicular Dendritic Cell (FDC)-Induced Microrna-Mediated up-Regulation of PRDM1 and Down-Regulation of BCL6 in Germinal Center B Lymphocytes: A Potential Mechanism for B-Cell Differentiation.

Jianhong Lin, MD, Tint Lwin, MD, PhD, Jianjun Zhao, MD, Jie Zhao, MD, Luis Crespo, BS, Eduardo M. Sotomayor, MD, Lynn C. Moscinski, MD, William S. Dalton, PhD, MD, Ken Wright, PhD, Jianguo Tao, MD, PhD

Blood (2009) 114 (22): 4588.

https://doi.org/10.1182/blood.V114.22.4588.4588

Published: 2009

Journal Articles

Cell Adhesion Induces p27Kip1-Associated Cell-Cycle Arrest through Down-Regulating SCF Skp2 Ubiquitin Ligase Pathway in Mantle Cell and Other Non-Hodgkin’s B-Cell Lymphomas.

Tint Lwin, MD, PhD, Lori A. Hazlehurst, PhD, Lynn C. Moscinski, MD, William S. Dalton, PhD,MD, Jianguo Tao, MD, PhD

Blood (2006) 108 (11): 2048.

https://doi.org/10.1182/blood.V108.11.2048.2048

Published: 2006

Journal Articles

Bone Marrow Stroma (BMS) Prevents Apoptosis of Lymphoma Cells by Upregulation of BMS-Derived B-Cell Activating Factor (BAFF) and Activation of NF-kB.

Tint Lwin, MD, PhD, Lori A. Hazlehurst, PhD, Lynn C. Moscinski, MD, William S. Dalton, PhD, MD, Jianguo Tao, MD, PhD

Blood (2006) 108 (11): 2378.

https://doi.org/10.1182/blood.V108.11.2378.2378

Published: 2006

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Pharmacoproteomics Identifies PLK1 As Vulnerability for Aggressive B-Cell Lymphomas

The Synergistic Effect of Melphalan and XPO1 Inhibition in Pre-Clinical Models of Multiple Myeloma

Next Generation XPO1 Inhibitor KPT-8602 for the Treatment of Drug-Resistant Multiple Myeloma

B Cell Receptor (BCR) Signal Pathways Confer Microenvironment-Mediated Drug Resistance and Are Promising Therapeutic Targets for B Cell Lymphomas

Silencing c-Myc Using Myc Inhibitor JQ1 and EZH2 Inhibitor DZNep Blocks Converging Survival Signals in Aggressive B-Cell Lymphomas

Targeting Mir-548m-HDAC6 Axis Circumvents Stroma- Mediated Drug Resistance (CAM-DR) and Clonogenicity in Non-Hodgkin B-Cell Lymphomas

Outcomes Analysis of Doublets of Novel Agents with Corticosteroids Versus Regimens with 3 or More Agents for Multiple Myeloma (MM): A Retrospective Analysis

Pyk2 Mediates Enhanced STAT3 Phosphorylation Following Collaborative Signaling Between gp130 and beta1 Integrins in Adhered Myeloma and B Cells

Selected Resistance to Topoisomerase II Inhibitors Correlates with the Over Expression of FANCF In a Fanconi Anemia/BRCA DNA Repair Pathway Independent Manner.

Characterization of Clonal Pre-B Cell Progenitors of Plasma Cells In Multiple Myeloma

Updated Results of the Phase II Study of Pegylated Liposomal Doxorubicin (PLD), Low Dose Dexamethasone (DEX) and Lenalidomide (LEN) In Patients with Newly Diagnosed (ND) Multiple Myeloma (MM)

Myc Represses miR15a/Mir-16-1 Expression through Recruitment of HDAC3 In Mantle Cell Lymphoma

Treatments and Outcomes of Patients with Multiple Myeloma (MM) Older Than 75 Years of Age: A Single Institution Experience

Microenvironment-Mediated Regulation of Micrornas In B-Lymphocytes as a Novel Mechanism for Terminal B-Cell Differentiation and Lymphomagenesis.

MiR-29 MicroRNAs Regulate IGF-1R Expression and Contribute Mantle Cell Lymphoma Growth and Survival.

A Novel Upregulation of Fanconi Anemia/BRCA DNA Repair Pathway Is Observed Upon Co-Culture of Bone Marrow Stroma with Multiple Myeloma Cell Lines: A Potential New Participant(s) in Environment Mediated Drug Resistance.

Bortezomib Reverts Stroma-Mediated Resistant to APO2L/TRAIL in Multiple Myeloma.

Follicular Dendritic Cell (FDC)-Induced Microrna-Mediated up-Regulation of PRDM1 and Down-Regulation of BCL6 in Germinal Center B Lymphocytes: A Potential Mechanism for B-Cell Differentiation.

Cell Adhesion Induces p27Kip1-Associated Cell-Cycle Arrest through Down-Regulating SCF Skp2 Ubiquitin Ligase Pathway in Mantle Cell and Other Non-Hodgkin’s B-Cell Lymphomas.

Bone Marrow Stroma (BMS) Prevents Apoptosis of Lymphoma Cells by Upregulation of BMS-Derived B-Cell Activating Factor (BAFF) and Activation of NF-kB.

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