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Journal Articles

Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?

Tohru Fujiwara, MD PhD, Chie Suzuki, Tetsuro Ochi, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 2232.

https://doi.org/10.1182/blood-2019-123918

Published: 2019

Journal Articles

Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells

Chie Suzuki, Tohru Fujiwara, MD PhD, Hiroki Shima, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 3523.

https://doi.org/10.1182/blood-2019-122618

Published: 2019

Journal Articles

Molecular Characterization and Novel Therapeutic Strategy for X-Linked Sideroblastic Anemia Associated with ALAS2 Missense Variants

Koya Ono, MD, Tohru Fujiwara, MD PhD, Kei Saito, MD PhD, Chie Suzuki, Noriyuki Takahashi, Koichi Onodera, MD PhD, Satoshi Ichikawa, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 3530.

https://doi.org/10.1182/blood-2019-124810

Published: 2019

Journal Articles

Generation and Molecular Characterization of Human Ring Sideroblasts

Kei Saito, Tohru Fujiwara, MD PhD, Shunsuke Hatta, Chie Suzuki, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD

Blood (2018) 132 (Supplement 1): 3613.

https://doi.org/10.1182/blood-2018-99-111066

Published: 2018

Journal Articles

Role of GATA2 in the Maintenance of the Bone Marrow Microenvironment

Shin Hasegawa, Tohru Fujiwara, MD PhD, Yoko Okitsu, MD PhD, Hiroki Kato, MD, PhD, Yuki Sato, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Kenichi Ishizawa, Ritsuko Shimizu, MD PhD, Masayuki Yamamoto, MD PhD, Hideo Harigae, MD

Blood (2017) 130 (Supplement 1): 3781.

https://doi.org/10.1182/blood.V130.Suppl_1.3781.3781

Published: 2017

Journal Articles

Establishment and Characterization of in Vitro Model of X-Linked Sideroblastic Anemia

Kei Saito, Tohru Fujiwara, MD PhD, Shunsuke Hatta, MD PhD, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD

Blood (2017) 130 (Supplement 1): 171.

https://doi.org/10.1182/blood.V130.Suppl_1.171.171

Published: 2017

Journal Articles

Transcription Factor Bach1 and Bach2 Operate Erythro-Myeloid Competitive Differentiation By Responding to Environmental Changes

Hiroki Kato, MD, Ari Itoh-Nakadai, PhD, Mitsuyo Matsumoto, PhD, Risa Ebina-Shibuya, MD PhD, Yuki Sato, MD, Masahiro Kobayashi, MD PhD, Akihiko Muto, PhD, Tohru Fujiwara, MD PhD, Hideo Harigae, MD PhD, Kazuhiko Igarashi, MD PhD

Blood (2016) 128 (22): 2649.

https://doi.org/10.1182/blood.V128.22.2649.2649

Published: 2016

Journal Articles

Generation of Induced Pluripotent Stem Cell-Derived Erythroblasts from a Patient with X-Linked Sideroblastic Anemia

Shunsuke Hatta, MD, PhD, Tohru Fujiwara, MD, PhD, Takako Yamamoto, Mayumi Kamata, MD, Yoshiko Tamai, Yukio Nakamura, MD, PhD, Shin Kawamata, Hideo Harigae, MD PhD

Blood (2016) 128 (22): 76.

https://doi.org/10.1182/blood.V128.22.76.76

Published: 2016

Journal Articles

Transcription Factor Bach1 and Bach2 Control Common Myeloid Progenitor Cell Differentiation Under Infectious Stimuli

Hiroki Kato, MD, Ari Itoh-Nakadai, PhD, Risa Ebina-Shibuya, MD, Masahiro Kobayashi, MD PhD, Mitsuyo Matsumoto, PhD, Akihiko Muto, PhD, Tohru Fujiwara, MD PhD, Hideo Harigae, MD PhD, Kazuhiko Igarashi, MD PhD

Blood (2015) 126 (23): 1164.

https://doi.org/10.1182/blood.V126.23.1164.1164

Published: 2015

Journal Articles

Impaired Lysophosphatidic Acid Receptor 3 Signaling in Mesenchymal Stromal Cells Promotes Multiple Myeloma Progression through Cellular Senescence and Transdifferentiation into Tumor-Associated Fibroblasts

Masahiko Kanehira, DVM, PhD, Tohru Fujiwara, MD PhD, Shinji Nakajima, MD PhD, Yoko Okitsu, MD PhD, Yasushi Ohnishi, MD PhD, Noriko Fukuhara, MD PhD, Ryo Ichinohasama, MD PhD, Hideo Harigae, MD PhD

Blood (2015) 126 (23): 1764.

https://doi.org/10.1182/blood.V126.23.1764.1764

Published: 2015

Journal Articles

GATA-2 Regulates Dendritic Cell Differentiation

Koichi Onodera, MD, PhD, Tohru Fujiwara, MD, PhD, Yasushi Onishi, MD, PhD, Ari Itoh-Nakadai, PhD, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Kenichi Ishizawa, MD, PhD, Ritsuko Shimizu, MD, PhD, Masayuki Yamamoto, MD, PhD, Hideo Harigae, MD, PhD

Blood (2015) 126 (23): 2382.

https://doi.org/10.1182/blood.V126.23.2382.2382

Published: 2015

Journal Articles

Exploring the Potential Usefulness of 5-Aminolevulinic Acid for X-Linked Sideroblastic Anemia

Tohru Fujiwara, MD PhD, Ryoyu Niikuni, Koji Okamoto, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Kenichi Ishizawa, MD PhD, Ryo Ichinohasama, MD PhD, Yukio Nakamura, MD, PhD, Tohru Tanaka, PhD, Hideo Harigae, MD PhD

Blood (2014) 124 (21): 215.

https://doi.org/10.1182/blood.V124.21.215.215

Published: 2014

Journal Articles

Impact of TET2 Deficiency on Iron Metabolism in Erythroblasts: A Potential Link to Ring Sideroblast Formation

Kyoko Inokura, MD, Tohru Fujiwara, MD PhD, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Kenichi Ishizawa, MD PhD, Kazuya Shimoda, MD PhD, Hideo Harigae, MD PhD

Blood (2014) 124 (21): 750.

https://doi.org/10.1182/blood.V124.21.750.750

Published: 2014

Journal Articles

Cellular Labile Iron Activates NLRP3 Inflammasome

Kyohei Nakamura, MDPhD, Tohru Fujiwara, MD PhD, Tomonori Ishii, MDPhD, Hideo Harigae, MD PhD, Kouetsu Ogasawara, PhD

Blood (2014) 124 (21): 2723.

https://doi.org/10.1182/blood.V124.21.2723.2723

Published: 2014

Journal Articles

Exploring The Mechanisms To Reveal The Contribution Of LMO2 To The Transcriptional Regulation In Human Erythroblasts

AI Inoue, MD, Tohru Fujiwara, MD, PhD, Yoko Okitsu, MD, PhD, Noriko Fukuhara, MD, PhD, Yasushi Onishi, MD, PhD, Kenichi Ishizawa, MD, Hideo Harigae, MD, PhD

Blood (2013) 122 (21): 2178.

https://doi.org/10.1182/blood.V122.21.2178.2178

Published: 2013

Journal Articles

A Low-Molecular-Weight Compound K7174 Represses Hepcidin: Possible Therapeutic Strategy Against Anemia Of Chronic Disease

Tohru Fujiwara, MD, PhD, Takashi Ikeda, Yuki Nagasaka, Yoko Okitsu, MD, PhD, Noriko Fukuhara, MD, PhD, Yasushi Onishi, MD, PhD, Kenichi Ishizawa, MD, Ryo Ichinohasama, MD, PhD, Naohisa Tomosugi, MD, PhD, Hideo Harigae, MD, PhD

Blood (2013) 122 (21): 3436.

https://doi.org/10.1182/blood.V122.21.3436.3436

Published: 2013

Journal Articles

Identification of the Novel Erythroid-Specific Enhancer in the First Intron of Human ALAS2 Gene; Tthe Mutation Disrupting GATA Transcription Factor-Binding Site in the Enhancer Causes X-Linked Sideroblastic Anemia

Kazumichi Furuyama, MD, PhD, Kiriko Kaneko, Ph.D., Tohru Fujiwara, MD, PhD, Hideo Harigae, MD, PhD, Shigeki Shibahara, M.D., Ph.D.

Blood (2012) 120 (21): 3185.

https://doi.org/10.1182/blood.V120.21.3185.3185

Published: 2012

Journal Articles

Elucidation of the Role of LMO2 (LIM-only protein 2) in Erythroid Cells

AI Inoue, MD, Tohru Fujiwara, MD, PhD, Yoko Okitsu, MD, PhD, Noriko Fukuhara, MD, PhD, Yasushi Onishi, MD, PhD, Kenichi Ishizawa, MD, PhD, Hideo Harigae, MD, PhD

Blood (2012) 120 (21): 3443.

https://doi.org/10.1182/blood.V120.21.3443.3443

Published: 2012

Journal Articles

Regulation of Erythropoiesis by Histone Methyltransferase EZH2 Inhibitor 3-Deazaneplanocin A (DZNep)

Tohru Fujiwara, MD, PhD, Haruka Saitoh, Yoko Okitsu, MD, PhD, Noriko Fukuhara, MD, PhD, Yasushi Onishi, MD, PhD, Kenichi Ishizawa, MD, PhD, Ryo Ichinohasama, MD, PhD, Hideo Harigae, MD, PhD

Blood (2012) 120 (21): 982.

https://doi.org/10.1182/blood.V120.21.982.982

Published: 2012

Journal Articles

Induction of Thymic Stromal Lymphopoietin in Mesenchymal Stem Cells by Interaction with Myeloma Cells

Shinji Nakajima, MD, PhD, Hiroto Ohguchi, MD, PhD, Yasushi Onishi, MD, PhD, Mayumi Kamata, MD, Tohru Fujiwara, MD, PhD, Yoko Okitsu, MD, PhD, Noriko Fukuhara, MD, PhD, Kenichi Ishizawa, MD, PhD, Hideo Harigae, MD, PhD

Blood (2012) 120 (21): 1825.

https://doi.org/10.1182/blood.V120.21.1825.1825

Published: 2012

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Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?

Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells

Molecular Characterization and Novel Therapeutic Strategy for X-Linked Sideroblastic Anemia Associated with ALAS2 Missense Variants

Generation and Molecular Characterization of Human Ring Sideroblasts

Role of GATA2 in the Maintenance of the Bone Marrow Microenvironment

Establishment and Characterization of in Vitro Model of X-Linked Sideroblastic Anemia

Transcription Factor Bach1 and Bach2 Operate Erythro-Myeloid Competitive Differentiation By Responding to Environmental Changes

Generation of Induced Pluripotent Stem Cell-Derived Erythroblasts from a Patient with X-Linked Sideroblastic Anemia

Transcription Factor Bach1 and Bach2 Control Common Myeloid Progenitor Cell Differentiation Under Infectious Stimuli

Impaired Lysophosphatidic Acid Receptor 3 Signaling in Mesenchymal Stromal Cells Promotes Multiple Myeloma Progression through Cellular Senescence and Transdifferentiation into Tumor-Associated Fibroblasts

GATA-2 Regulates Dendritic Cell Differentiation

Exploring the Potential Usefulness of 5-Aminolevulinic Acid for X-Linked Sideroblastic Anemia

Impact of TET2 Deficiency on Iron Metabolism in Erythroblasts: A Potential Link to Ring Sideroblast Formation

Cellular Labile Iron Activates NLRP3 Inflammasome

Exploring The Mechanisms To Reveal The Contribution Of LMO2 To The Transcriptional Regulation In Human Erythroblasts

A Low-Molecular-Weight Compound K7174 Represses Hepcidin: Possible Therapeutic Strategy Against Anemia Of Chronic Disease

Identification of the Novel Erythroid-Specific Enhancer in the First Intron of Human ALAS2 Gene; Tthe Mutation Disrupting GATA Transcription Factor-Binding Site in the Enhancer Causes X-Linked Sideroblastic Anemia

Elucidation of the Role of LMO2 (LIM-only protein 2) in Erythroid Cells

Regulation of Erythropoiesis by Histone Methyltransferase EZH2 Inhibitor 3-Deazaneplanocin A (DZNep)

Induction of Thymic Stromal Lymphopoietin in Mesenchymal Stem Cells by Interaction with Myeloma Cells

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American Society of Hematology

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