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Robert MacLeod, PhD
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Journal Articles

Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma

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Antonio Sacco, RN, Cinzia Federico, PhD, Katia Todoerti, PhD, Bachisio Ziccheddu, PhD, Arianna Giacomini, PhD, Cosetta Ravelli, PhD, Federica Maccarinelli, PhD, Giada Bianchi, MD, Angelo Belotti, Rossella Ribolla, MD, Vanessa Favasuli, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brandon Willis, PhD, Hongoo Cai, PhD, Joana Hauser, RN, Claire Rooney, PhD, Helen Ambrose, PhD, Anna Staniszewska, PhD, Lyndsey Hanson, PhD, Giuseppe Rossi, Roberto Ronca, PhD, Antonino Neri, MD, Stefania Mitola, PhD, Niccolò Bolli, MD PhD, Marco Presta, PhD, Michele Moschetta, MD PhD, Sarah Ross, PhD, Aldo M. Roccaro, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3104.
https://doi.org/10.1182/blood-2019-124391
Published: 2019
Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

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Maria E Balasis, Alexis Vedder, BS, Lei Sun, Ariel Quintana, PhD, Abhishek Dhawan, Hannah Newman, BS, Jane Merlevede, Kathy McGraw, PhD, Traci Kruer, PhD, Nana Ben-Crentsil, Jeffrey S Painter, BS, Nathalie Droin, PhD, Thomas Cluzeau, MD PhD, Christopher Letson, BS, Sheng Wei, MD, Rami S. Komrokji, MD, Hailing Zhang, MD, A. Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD PhD, Pearlie K. Epling-Burnette, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1692.
https://doi.org/10.1182/blood-2019-128573
Published: 2019
Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

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Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 364.
https://doi.org/10.1182/blood.V130.Suppl_1.364.364
Published: 2017
Journal Articles

Therapeutic Targeting of Interferon Regulatory Factor 4 with Next Generation Antisense Oligonucleotides Produces Robust In Vivo Antitumor Activity in Preclinical Models of Multiple Myeloma

Free
Tianyuan Zhou, PhD, Joanna Schmidt, Youngsoo Kim, PhD, A. Robert MacLeod, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3078.
https://doi.org/10.1182/blood.V130.Suppl_1.3078.3078
Published: 2017
Journal Articles

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Free
Mark B Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, MS, Liang Nong, MD, Ismael Rosado-Lopez, Tuan Nguyen, Jennifer E. Ring, William Matsui, MD, Robert MacLeod, PhD, David T. Weaver, PhD, Jonathan A. Pachter, PhD, Lori A. Hazlehurst, PhD, John M. Koomen, PhD, Kenneth H. Shain, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3008.
https://doi.org/10.1182/blood.V126.23.3008.3008
Published: 2015
Journal Articles

Molecular Characterization of SRSF2 Mutation Identifies a Clinically Relevant Lncrna (MALAT1) in Chronic Myelomonocytic Leukemia (CMML)

Free
Maria E. Balasis, Jane Merelvede, Sateesh Kunigal, Xiaoyi Ren, Yan Ma, Qing Zhang, PhD, Jeff Painter, Nathalie M. Droin, PhD, Joseph Johnson, Sean Yoder, M.S, Rami S. Komrokji, MD, Ling Zhang, MD, Sheng Wei, MD, Torsten Haferlach, Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD Prof, P.K. Epling-Burnette, PhD, Eric Padron, MD
Journal: Blood
Blood (2015) 126 (23): 1641.
https://doi.org/10.1182/blood.V126.23.1641.1641
Published: 2015
Journal Articles

Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death

Free
Kenneth H. Shain, MD PhD, Mark B Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, Liang Nong, MD, Ismael Rosado-Lopez, BS, Jennifer E. Ring, Robert MacLeod, PhD, Lori Hazlehurst, PhD, Conor Lynch, PhD, Jonathan A. Pachter, PhD, William Matsui, MD, John Koomen, PhD, Tuan Nguyen
Journal: Blood
Blood (2014) 124 (21): 2081.
https://doi.org/10.1182/blood.V124.21.2081.2081
Published: 2014
Journal Articles

PYK2 Mediates Microenvironment-Specific Myeloma Survival

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Mark Meads, PhD, Bin Fang, PhD, Linda Mathews, Jennifer Gemmer, Liang Nong, M.D., Lori A Hazlehurst, Ph.D, Robert MacLeod, PhD, John Koomen, Ph.D., Kenneth Shain, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4443.
https://doi.org/10.1182/blood.V122.21.4443.4443
Published: 2013
Journal Articles

Combination of FXI Antisense Oligonucleotide and Plavix® Treatment Results in Enhanced Antithrombotic Activity without Increased Risk of Bleeding in Mouse Models of Thrombosis.

Free
Dacao Gao, Jeff Crosby, PhD, Robert MacLeod, PhD, Gourab Bhattacharjee, PhD, Ester C Lowenberg, MD, Marcel Levi, MD, PhD, Prof., Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4173.
https://doi.org/10.1182/blood.V114.22.4173.4173
Published: 2009
Journal Articles

Systematic Evaluation of Coagulation Factors as Targets for Anti-Thrombotic Therapy Using Antisense Technology.

Free
Jeff Crosby, PhD, Dacao Gao, Chenguang Zhao, Gourab Bhattacharjee, PhD, Chris May, Hong Zhang, MD, Robert MacLeod, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4181.
https://doi.org/10.1182/blood.V114.22.4181.4181
Published: 2009
Journal Articles

Pharmacological Characterization and Structure Activity Relationship of FXI Antisense Oligonucleotides in Cynomolgus Monkeys.

Free
Robert MacLeod, PhD, Jeff Crosby, PhD, Chenguang Zhao, Dacao Gao, Chris May, Hong Zhang, MD, Ester C Lowenberg, MD, Marcel Levi, Prof. MD, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 2101.
https://doi.org/10.1182/blood.V114.22.2101.2101
Published: 2009