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Journal Articles

NUTM1 Is a Rare but Recurrent Fusion Gene Partner in B Cell Precursor Acute Lymphoblastic Leukemia Associated with Increased Expression of Genes on Cytoband 10p12.31

Femke M. Hormann, MSc, Alex Q. Hoogkamer, BSc, H. Berna Beverloo, PhD, Aurélie Boeree, BSc, Ronald W. Stam, PhD, Gabriele Escherich, Rob Pieters, MD PhD MSc, Monique L. Den Boer, PhD, Judith M. Boer, PhD

Blood (2018) 132 (Supplement 1): 2823.

https://doi.org/10.1182/blood-2018-99-112480

Published: 2018

Journal Articles

A Treatment Protocol with Imatinib and Intensive Chemotherapy for Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia Patients: A Single-Arm, Intergroup Study (EsPhALL 2010-2014)

Andrea Biondi, MD, Virginie Gandemer, MDPhD, Myriam Campbell, MD, Anders Castor, MD PhD, Rob Pieters, MD PhD, Paola De Lorenzo, PhD, Veronica Leoni, MD, Jan Stary, Gabriele Escherich, MD, Chi Kong Li, MD, Giovanni Cazzaniga, PhD, Helene Cave, PharmD, PhD, Silja Roettgers, PhD, Valentino Conter, MD, Vaskar Saha, MD PhD, Martin Schrappe, MD PhD, Maria Grazia Valsecchi, PhD

Blood (2017) 130 (Supplement 1): 97.

https://doi.org/10.1182/blood.V130.Suppl_1.97.97

Published: 2017

Journal Articles

Irinotecan Induces Complete Remission in MLL -Rearranged Acute Lymphoblastic Leukemia Xenografts

Patricia Garrido Castro, PhD, Mark Kerstjens, MSc, Sandra S Pinhanços, MSc, Pauline Schneider, BSc, Priscilla Wander, MSc, Rob Pieters, MD PhD, Ronald Stam, PhD

Blood (2017) 130 (Supplement 1): 3877.

https://doi.org/10.1182/blood.V130.Suppl_1.3877.3877

Published: 2017

Journal Articles

High PDGFRA Expression Does Not Serve As Effective Therapeutic Target in ERG -Deleted B-Cell Precursor Acute Lymphoblastic Leukemia

Isabel S. Jerchel, MSc, Judith M. Boer, PhD, Alex Q. Hoogkamer, BSc, H. Berna Beverloo, PhD, Rob Pieters, MD PhD, Monique L. den Boer, PhD

Blood (2017) 130 (Supplement 1): 1274.

https://doi.org/10.1182/blood.V130.Suppl_1.1274.1274

Published: 2017

Journal Articles

Breaking IL7R Signaling-Induced Glucocorticoid Resistance By Small Molecule Inhibitors in T-Cell Acute Lymphoblastic Leukemia

Jordy Van Der Zwet, MD, Jules Meijerink, PhD, Jessica Buijs-Gladdines, Yunlei Li, PhD, Rob Pieters, MD PhD

Blood (2017) 130 (Supplement 1): 2534.

https://doi.org/10.1182/blood.V130.Suppl_1.2534.2534

Published: 2017

Journal Articles

a Decrease in Vitamin D Levels Is Associated with Methotrexate-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia

Natanja Oosterom, MD, Niek Dirks, MSc, Sandra Heil, Robert de Jonge, Wim Tissing, MD, Rob Pieters, MD PhD, Marry M van den Heuvel-Eibrink, Prof.Dr., Annemieke Heijboer, Saskia Pluijm

Blood (2017) 130 (Supplement 1): 2573.

https://doi.org/10.1182/blood.V130.Suppl_1.2573.2573

Published: 2017

Journal Articles

The Predictive Value of Vitamin D Serum Concentration for Osteopenia and Fractures in Children with Hematological Malignancies

Jenneke E. Van Atteveld, BSc, Iris E. Verhagen, BSc, Rob Pieters, MD PhD, M.M. Van Den Van Den Heuvel-Eibrink, Saskia M.F. Pluijm, PhD

Blood (2017) 130 (Supplement 1): 5003.

https://doi.org/10.1182/blood.V130.Suppl_1.5003.5003

Published: 2017

Journal Articles

JAK2 Aberrations in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

Elisabeth M.P. Steeghs, MSc, Isabel S. Jerchel, MSc, Willemieke de Goffau-Nobel, MSc, Alex Q. Hoogkamer, BSc, Judith M. Boer, PhD, Aurélie Boeree, BSc, Cesca van de Ven, PhD, Marco J. Koudijs, PhD, Nicolle J.M. Besselink, BSc, Hester A. de Groot-Kruseman, PhD, C. Michel Zwaan, MD PhD, Martin A. Horstmann, MD, Rob Pieters, MD PhD, Monique L. Den Boer, PhD

Blood (2016) 128 (22): 583.

https://doi.org/10.1182/blood.V128.22.583.583

Published: 2016

Journal Articles

RAS Pathway Mutations As Predictive Biomarker for Treatment Adaptation in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Isabel S. Jerchel, MSc, Alex Q. Hoogkamer, BSc, Ingrid M. Ariës, PhD, Elisabeth M.P. Steeghs, MSc, Judith M. Boer, PhD, Nicolle J.M. Besselink, BSc, Aurélie Boeree, BSc, Cesca van de Ven, PhD, Hester A. de Groot-Kruseman, PhD, Valerie De Haas, MD PhD, Martin A. Horstmann, MD, Gabriele Escherich, MD, Ronald W. Stam, PhD, C. Michel Zwaan, MD PhD, Edwin Cuppen, PhD, Marco J. Koudijs, PhD, Rob Pieters, MD PhD, Monique L. Den Boer, MSc, PhD

Blood (2016) 128 (22): 4087.

https://doi.org/10.1182/blood.V128.22.4087.4087

Published: 2016

Journal Articles

Clinical Relevance of Tyrosine Kinase Fusion Genes in Pediatric BCR-ABL1 -like Acute Lymphoblastic Leukemia

Judith M. Boer, PhD, Aurélie Boeree, BSc, João R.M. Marchante, MSc, Berna Beverloo, PhD, Gabriele Escherich, MD, Hester A. de Groot-Kruseman, PhD, Rob Pieters, MD PhD, Monique L. Den Boer, PhD

Blood (2015) 126 (23): 3735.

https://doi.org/10.1182/blood.V126.23.3735.3735

Published: 2015

Journal Articles

T-Cell Acute Lymphoblastic Leukemia Patients with Mutations in IL7Ra or Downstream RAS-MEK or PI3K-AKT Can be Collectively Targeted By Combination of RAS and AKT Inhibitors

Kirsten Canté-Barrett, PhD, Jill AP Spijkers-Hagelstein, Jessica GCAM Buijs-Gladdines, Wilco K Smits, Rogier C Buijsman, PhD, Guido JR Zaman, PhD, Rob Pieters, MD PhD, Jules PP Meijerink, PhD

Blood (2015) 126 (23): 445.

https://doi.org/10.1182/blood.V126.23.445.445

Published: 2015

Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia Cells Create a Self-Reinforcing Niche Independent of the CXCR4/CXCL12 Axis

Bob de Rooij, MSc, Roel Polak, MD, Rob Pieters, MD PhD, Monique L. Den Boer, PhD

Blood (2015) 126 (23): 1297.

https://doi.org/10.1182/blood.V126.23.1297.1297

Published: 2015

Journal Articles

CNOT1 Microrna Single Nucleotide Polymorphism (SNP) Determines the Occurrence of Methotrexate Related Mucositis in Pediatric Acute Lymphoblastic Leukemia

Natanja Oosterom, Ángela Guttiérez-Camino, Marissa Den Hoed, Elixabet López-López, Saskia MF Pluijm, Rob Pieters, MD PhD, Robert de Jonge, Wim JE Tissing, MD PhD, África García-Orad, Sandra G Heil, Marry M van den Heuvel-Eibrink

Blood (2015) 126 (23): 1237.

https://doi.org/10.1182/blood.V126.23.1237.1237

Published: 2015

Journal Articles

Identification of Candidate Oncogenes and Chromosomal Breakpoint Sequencing By Targeted Locus Amplification in T-Cell Acute Lymphoblastic Leukemia

Eric M Vroegindeweij, PhD, Tim Lammens, PhD, Erik Splinter, PhD, Anne Uyttebroeck, Kirsten Canté-Barrett, PhD, Jessica GCAM Buijs-Gladdines, Wilco K Smits, Peter Vandenberghe, MD PhD, Max J van Min, PhD, Rob Pieters, MD PhD, Pieter Van Vlierberghe, PhD, Jules PP Meijerink, PhD

Blood (2015) 126 (23): 1409.

https://doi.org/10.1182/blood.V126.23.1409.1409

Published: 2015

Journal Articles

Population Pharmacokinetics of Erwinia Asparaginase in Pediatric ALL Patients

Sebastiaan D.T. Sassen, PharmD, Ron A.A. Mathôt, PharmD, PhD, Rob Pieters, MD PhD, Valerie de Haas, MD PhD, Gertjan JL Kaspers, MD PhD, Cor van den Bos, MDPhD, Wim JE Tissing, MD PhD, Maroeska D.W.M. te Loo, MD PhD, Marc B Bierings, MDPhD, Wouter J.W. Kollen, MD PhD, Christian M. Zwaan, MD PhD, Inge M. van der Sluis, MD PhD

Blood (2015) 126 (23): 1281.

https://doi.org/10.1182/blood.V126.23.1281.1281

Published: 2015

Journal Articles

Constitutive Activation of FLT3 Is a Positive Prognostic Factor in Infants with MLL-Rearranged Acute Lymphoblastic Leukemia

Henning Fedders, PhD, Denis Martin Schewe, MD, Martin Zimmermann, PhD, Ameera Alsadeq, PhD, Anja Moericke, MD, Udo zur Stadt, PhD, Martin A. Horstmann, MD, Rob Pieters, MD PhD, Martin Schrappe, MD PhD, Gunnar Cario, MD, Martin Stanulla, MD

Blood (2015) 126 (23): 1417.

https://doi.org/10.1182/blood.V126.23.1417.1417

Published: 2015

Journal Articles

Constitutive Expression of MEF2C, LYL1, or LMO2 in CD34 + HSCs Blocks the in Vitro Differentiation before the T-Cell Commitment Point and Could be Oncogenic in Early T-Cell Progenitor ALL

Kirsten Canté-Barrett, PhD, Rui D Mendes, Wilco K Smits, Rob Pieters, MD PhD, Jules PP Meijerink, PhD

Blood (2015) 126 (23): 2423.

https://doi.org/10.1182/blood.V126.23.2423.2423

Published: 2015

Journal Articles

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Jiangyan Yu, MSc, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Rob Pieters, MD PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD PhD, Roland P. Kuiper, PhD

Blood (2015) 126 (23): 247.

https://doi.org/10.1182/blood.V126.23.247.247

Published: 2015

Journal Articles

Prognostic Relevance of Recurrent Genetic Aberrations in Pediatric Acute Megakaryoblastic Leukemia

Jasmijn de Rooij, MD, Riccardo Masetti, MD, Marry M. van den Heuvel-Eibrink, MD PhD, Jean-Michel Cayuela, Jan Trka, Dirk Reinhardt, MD, Edwin Sonneveld, PhD, Todd A. Alonzo, PhD, Maarten Fornerod, Martin Zimmermann, Martina Pigazzi, PhD, Rob Pieters, MD PhD, Soheil Meshinchi, MD PhD, C. Michel Zwaan, Franco Locatelli

Blood (2015) 126 (23): 2598.

https://doi.org/10.1182/blood.V126.23.2598.2598

Published: 2015

Journal Articles

A Phase 1/2, Open-Label, Dose-Escalation Study of Midostaurin in Pediatric Patients (Pts) with Relapsed or Refractory (R/R) Acute Leukemia: Final Results of Study ITCC-024 (CPKC412A2114)

C. Michel Zwaan, MD PhD, Stefan Söderhäll, MD PhD, Benoit Brethon, MD, Matteo Luciani, MD, Carmelo Rizzari, MD, David Sternberg, MD PhD, Emmanuelle Besse, Catherine Dutreix, MD, Franca Fagioli, MD, Phoenix Ho, MD, Carlo Dufour, MD, Rob Pieters, MD PhD

Blood (2015) 126 (23): 2564.

https://doi.org/10.1182/blood.V126.23.2564.2564

Published: 2015

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NUTM1 Is a Rare but Recurrent Fusion Gene Partner in B Cell Precursor Acute Lymphoblastic Leukemia Associated with Increased Expression of Genes on Cytoband 10p12.31

A Treatment Protocol with Imatinib and Intensive Chemotherapy for Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia Patients: A Single-Arm, Intergroup Study (EsPhALL 2010-2014)

Irinotecan Induces Complete Remission in MLL -Rearranged Acute Lymphoblastic Leukemia Xenografts

High PDGFRA Expression Does Not Serve As Effective Therapeutic Target in ERG -Deleted B-Cell Precursor Acute Lymphoblastic Leukemia

Breaking IL7R Signaling-Induced Glucocorticoid Resistance By Small Molecule Inhibitors in T-Cell Acute Lymphoblastic Leukemia

a Decrease in Vitamin D Levels Is Associated with Methotrexate-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia

The Predictive Value of Vitamin D Serum Concentration for Osteopenia and Fractures in Children with Hematological Malignancies

JAK2 Aberrations in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

RAS Pathway Mutations As Predictive Biomarker for Treatment Adaptation in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Clinical Relevance of Tyrosine Kinase Fusion Genes in Pediatric BCR-ABL1 -like Acute Lymphoblastic Leukemia

T-Cell Acute Lymphoblastic Leukemia Patients with Mutations in IL7Ra or Downstream RAS-MEK or PI3K-AKT Can be Collectively Targeted By Combination of RAS and AKT Inhibitors

B-Cell Precursor Acute Lymphoblastic Leukemia Cells Create a Self-Reinforcing Niche Independent of the CXCR4/CXCL12 Axis

CNOT1 Microrna Single Nucleotide Polymorphism (SNP) Determines the Occurrence of Methotrexate Related Mucositis in Pediatric Acute Lymphoblastic Leukemia

Identification of Candidate Oncogenes and Chromosomal Breakpoint Sequencing By Targeted Locus Amplification in T-Cell Acute Lymphoblastic Leukemia

Population Pharmacokinetics of Erwinia Asparaginase in Pediatric ALL Patients

Constitutive Activation of FLT3 Is a Positive Prognostic Factor in Infants with MLL-Rearranged Acute Lymphoblastic Leukemia

Constitutive Expression of MEF2C, LYL1, or LMO2 in CD34 + HSCs Blocks the in Vitro Differentiation before the T-Cell Commitment Point and Could be Oncogenic in Early T-Cell Progenitor ALL

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Prognostic Relevance of Recurrent Genetic Aberrations in Pediatric Acute Megakaryoblastic Leukemia

A Phase 1/2, Open-Label, Dose-Escalation Study of Midostaurin in Pediatric Patients (Pts) with Relapsed or Refractory (R/R) Acute Leukemia: Final Results of Study ITCC-024 (CPKC412A2114)

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