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Journal Articles

The Pan-PIM Kinase Inhibitor LGH447 Shows Activity In PIM2-Dependent Multiple Myeloma and In AML Models

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Pablo D Garcia, PhD, John L Langowski, Ph.D., Jocelyn Holash, Ph.D., Matthew Burger, Ph.D., Richard Zang, Ph.D., Tatiana Zavorotinskaya, PhD, Christie Fanton, PhD, Abdel Saci, Ph.D., Joseph Growney, Ph.D., K. Gary Vanasse, M.D.
Journal: Blood
Blood (2013) 122 (21): 1666.
https://doi.org/10.1182/blood.V122.21.1666.1666
Published: 2013
Journal Articles

The Combination Of JAK Inhibitor, Ruxolitinib, and PIM Inhibitor, LGH447, In Preclinical Models Of Myeloproliferative Neoplasia

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Abdel Saci, Ph.D., Maria Pinzon-Ortiz, Dannie Wang, Xianhui Rong, Joseph Growney, Ph.D., Margaret Squier, MD, PhD, Thomas Radimerski, PhD, K. Gary Vanasse, Giordano Caponigro, Pablo D Garcia, PhD, Z. Alexander Cao
Journal: Blood
Blood (2013) 122 (21): 4100.
https://doi.org/10.1182/blood.V122.21.4100.4100
Published: 2013
Journal Articles

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

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Jing Lu, Tatiana Zavorotinskaya, Yumin Dai, Xiao-Hong Niu, Joseph Castillo, Janet Sim, Jianjun Yu, Yingyun Wang, John L. Langowski, Jocelyn Holash, Kevin Shannon, Pablo D. Garcia
Journal: Blood
Blood (2013) 122 (9): 1610–1620.
https://doi.org/10.1182/blood-2013-01-481457
Published: 2013
Includes: Supplemental data