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Journal Articles

Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia

Diu T.T. Nguyen, DPhil, Camila Prieto, PhD, Zhaoqi Liu, PhD, Justin Wheat, Alexendar Perez, Saroj Gourkanti, BA, Timothy Chou, BS, Ersilia Barin, Arthur Chow, BS, James Taggart, BA, Katerina Hoskova, Meera Dhodapkar, Alexandra Schurer, BS, Trevor Stephen Barlowe, BA, Ly Vu, PhD, Christina Leslie, PhD, Ulrich G. Steidl, MDPhD, Raul Rabadan, PhD, Michael G. Kharas, PhD

Blood (2020) 136 (Supplement 1): 15.

https://doi.org/10.1182/blood-2020-142229

Published: 2020

Journal Articles

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 428.

https://doi.org/10.1182/blood-2018-99-118745

Published: 2018

Journal Articles

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

Josephine Wesely, PhD MSc, BSc, Andriana G. Kotini, PhD, Maria Georgomanoli, PhD, Hanzhi Luo, PhD, Han Yuan, Franco Izzo, PhD, Dan A. Landau, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD, Eirini P. Papapetrou, MD PhD

Blood (2018) 132 (Supplement 1): 772.

https://doi.org/10.1182/blood-2018-99-111506

Published: 2018

Journal Articles

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

Sun-Mi Park, PhD, Hyunwoo Cho, PhD, Angela Thornton, PhD, Trevor Stephen Barlowe, BA, Timothy Chou, BS, Sagar Chhangawala, PhD, Lauren Fairchild, PhD, Arthur Chow, BA, James Taggart, BA, Alexander Schurer, BA, Antoine Gruet, Matthew Witkin, Jun Hyun Kim, Ethan Shevach, Andrei Krivstov, Scott A. Armstrong, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 3881.

https://doi.org/10.1182/blood-2018-99-115034

Published: 2018

Journal Articles

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Camila Prieto, BA, Diu Nguyen, PhD, Ly P Vu, PhD, Alexendar Perez, PhD, Saroj Gourkanti, BA, Alexandra Schurer, BS, Timothy Chou, BS, Arthur Chow, BA, James Taggart, BA, Trevor Stephen Barlowe, BA, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 883.

https://doi.org/10.1182/blood-2018-99-112543

Published: 2018

Journal Articles

The RNA Binding Protein MSI2 Has Increased RNA Binding Activity in Leukemic Stem Cells Compared to Normal Hematopoietic Stem Cells

Diu Nguyen, PhD, Yuheng Lu, PhD, Zi-ning Choo, Christopher Chin, Camila Prieto, BA, Saroj Gourkanti, BA, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 884.

https://doi.org/10.1182/blood-2018-99-118949

Published: 2018

Journal Articles

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

Lauren Forbes, BS, MS, Krasnopolsky Isaac, BA, Gerard Minuesa Dinares, PhD, Michael G. Kharas, PhD, Alex Kentsis, MD PhD

Blood (2018) 132 (Supplement 1): 1352.

https://doi.org/10.1182/blood-2018-99-118807

Published: 2018

Journal Articles

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

Yuanming Cheng, PhD, Hanzhi Luo, PhD, Franco Izzo, PhD, Brian F Pickering, PhD, Ly P Vu, PhD, Alexandra Schurer, BS, Saroj Gourkanti, BA, Samie R. Jaffrey, MD PhD, Dan A. Landau, MD PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 327.

https://doi.org/10.1182/blood-2018-99-117191

Published: 2018

Journal Articles

m 6 a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia

Ly P Vu, PhD, Brian F Pickering, PhD, Yuanming Cheng, PhD, Zaccara Sara, PhD, Diu Nguyen, PhD, Gerard Minuesa, PhD, Timothy Chou, BS, Arthur Chow, BS, Matthew MacKay, Christopher Famulare, MS, Minal Patel, BA, Francine Garret-Bakelman, MD PhD, Ari Melnick, MD, Martin Carroll, MD, Christopher Mason, PhD, Samie R. Jaffrey, MD PhD, Michael G. Kharas, PhD

Blood (2017) 130 (Supplement 1): 791.

https://doi.org/10.1182/blood.V130.Suppl_1.791.791

Published: 2017

Journal Articles

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Kavitha Ramaswamy, MD, Lauren Forbes, Fiona C Brown, PhD, Richard Koche, PhD, Tatyana Gindin, MDPhD, Gerard Minuesa, PhD, Michael G. Kharas, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD, Eric Still, Elisa de Stanchina, PhD, Randi Isenhart, Guangwu Guo, Birgit Knoechel, MDPhD, Alex Kentsis, MD PhD

Blood (2016) 128 (22): 3945.

https://doi.org/10.1182/blood.V128.22.3945.3945

Published: 2016

Journal Articles

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Blood (2016) 128 (22): 739.

https://doi.org/10.1182/blood.V128.22.739.739

Published: 2016

Journal Articles

MSI2 Is Required for Maintaining the Activated Myelodysplastic Syndrome Stem Cell

Tzu-Chieh Ho, PhD, James Taggart, BS, Elianna Amin, PhD, Haiming Xu, PhD, Trevor Barlowe, BA, Alexander R Perez, BS, Patrick Tivnan, BS, Rachel Okabe, BS, Christopher Lengner, PhD, Amit Verma, MD, Gail J Roboz, MD, Monica L. Guzman, PhD, Christina S Leslie, PhD, Stephen D. Nimer, MD, Michael G. Kharas, PhD

Blood (2015) 126 (23): 714.

https://doi.org/10.1182/blood.V126.23.714.714

Published: 2015

Journal Articles

IKZF2, a Novel Target of MSI2 RNA-Binding Protein Plays an Oncogenic Role in Myeloid Leukemia

Sun Mi Park, PhD, Angela Thornton, PhD, Ly P. Vu, PhD, Sagar Chhangawala, Gerard Minuesa, PhD, Trevor Barlowe, BA, James Taggart, BS, Patrick Tivnan, BS, Theodore Kim, Ethan Shevach, MD, Christina S Leslie, PhD, Michael G. Kharas, PhD

Blood (2015) 126 (23): 440.

https://doi.org/10.1182/blood.V126.23.440.440

Published: 2015

Journal Articles

Integrative Analysis of the Mutational Landscape of Mouse and Human AML Identifies Functionally Relevant Leukemia Disease Alleles

Megan A. Hatlen, PhD, Kanika Arora, MS, Vladimir Vacic, PhD, Ewa A. Grabowska, BS, Willey Liao, BS, Bridget Riley-Gillis, PhD, Dayna M. Oschwald, BS, Lan Wang, PhD, Jacob E. Joergens, Alan H. Shih, MD PhD, Franck Rapaport, PhD, Shengqing Gu, PhD, Francesca Voza, BS, Takashi Asai, MD PhD, Benjamin Neel, MD PhD, Michael G. Kharas, PhD, Mithat Gonen, PhD, Ross L. Levine, MD, Stephen D. Nimer, MD

Blood (2015) 126 (23): 1247.

https://doi.org/10.1182/blood.V126.23.1247.1247

Published: 2015

Journal Articles

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program

Sun Mi Park, PhD, Mithat Gönen, PhD, Ly P. Vu, PhD, Gerard Minuesa, PhD, Patrick Tivnan, Trevor Barlowe, James Taggart, Yuheng Lu, Raquel P Deering, PhD, Nir Hacohen, PhD, Maria Figueroa, MD, Elisabeth M. Paietta, PhD, Martin S. Tallman, MD, Ari M. Melnick, MD, Ross L. Levine, MD, Christina Leslie, PhD, Christopher J Lengner, PhD, Michael G Kharas, PhD

Blood (2014) 124 (21): 836.

https://doi.org/10.1182/blood.V124.21.836.836

Published: 2014

Journal Articles

Msi2 Directly Regulates The TGF-β Signaling Pathway and Myeloid Lineage Bias In Hematopoietic Stem Cells

Sun-Mi Park, Ph.D, Raquel P Deering, Yuheng Lu, Tivnan Patrick, Varun Shenoy, Steve Lianoglou, Ph.D, Fatima Al-Shahrour, Christina Leslie, Benjamin L. Ebert, MD, PhD, Christopher Lengner, George Q Daley, Michael G Kharas, PhD

Blood (2013) 122 (21): 468.

https://doi.org/10.1182/blood.V122.21.468.468

Published: 2013

Journal Articles

Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate.

Sun Mi Park, Ph.D, Raquel Deering, Yuheng Lu, Patrick Tivnan, Varun Shenoy, Steve Lianoglou, Ph.D, Fatima Al-Shahrour, PhD, Christina Leslie, PhD, Benjamin L. Ebert, MD, PhD, Christopher Lengner, Ph.D, George Q. Daley, MD, PhD, Michael G Kharas, PhD

Blood (2012) 120 (21): 2324.

https://doi.org/10.1182/blood.V120.21.2324.2324

Published: 2012

Journal Articles

Casein Kinase 1 Alpha Maintains Normal and Leukemic Stem Cells by Regulating p53 Activity

Marcus Järås, PhD, Peter G. Miller, PhD, Lisa Chu, Rebekka K. Schneider, MD, Rishi V Puram, Fatima Al-Shahrour, PhD, Emma Fink, Kimberly A. Hartwell, PhD, Marie McConkey, Glenn Cowley, PhD, Ann Mullally, MD, Michael G Kharas, PhD, Benjamin L. Ebert

Blood (2012) 120 (21): 209.

https://doi.org/10.1182/blood.V120.21.209.209

Published: 2012

Journal Articles

Msi2 Maintains Normal Hematopoietic Stem Cell Self-Renewal

Michael G Kharas, PhD, Christopher Lengner, Ph.D, Fatima Al-Shahrour, PhD, Benjamin L. Ebert, MD, D.Phil, George Q. Daley, MD, PhD

Blood (2011) 118 (21): 222.

https://doi.org/10.1182/blood.V118.21.222.222

Published: 2011

Journal Articles

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

Blood (2011) 118 (21): 758.

https://doi.org/10.1182/blood.V118.21.758.758

Published: 2011

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Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

The RNA Binding Protein MSI2 Has Increased RNA Binding Activity in Leukemic Stem Cells Compared to Normal Hematopoietic Stem Cells

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

m 6 a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

MSI2 Is Required for Maintaining the Activated Myelodysplastic Syndrome Stem Cell

IKZF2, a Novel Target of MSI2 RNA-Binding Protein Plays an Oncogenic Role in Myeloid Leukemia

Integrative Analysis of the Mutational Landscape of Mouse and Human AML Identifies Functionally Relevant Leukemia Disease Alleles

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program

Msi2 Directly Regulates The TGF-β Signaling Pathway and Myeloid Lineage Bias In Hematopoietic Stem Cells

Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate.

Casein Kinase 1 Alpha Maintains Normal and Leukemic Stem Cells by Regulating p53 Activity

Msi2 Maintains Normal Hematopoietic Stem Cell Self-Renewal

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

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American Society of Hematology

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