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Journal Articles

CD34+ Positive Myelodysplastic Cells with Ring Sideroblasts or SF3B1 Mutation Produce High Erythroferrone and GDF15

Hiroto Horiguchi, MDPhD, Masayoshi Kobune, MD PhD, Kento Ono, MD, Saori Shimoyama, MD, Chisa Fujita, MD, Akari Goto, MDPhD, Hiroshi Ikeda, MDPhD, Satoshi Iyama, MD PhD

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-134861

Published: 2020

Journal Articles

Extravesicular Mir-7977 Released from Leukemic Cells Inhibites the PCBP1-Mediated mRNA Stabilization and Hippo-YAP Signaling Pathway in Bone Marrow Mesenchymal Stromal Cells

Masahiro Yoshida, MD PhD, Satoshi Iyama, MD PhD, Hiroto Horiguchi, MD PhD, Akari Goto, MD PhD, Shohei Kikuchi, MD PhD, Kazuyuki Murase, MD PhD, Kohichi Takada, MD PhD, Koji Miyanishi, MD PhD, Hiroshi Ikeda, MD PhD, Masahiro Maeda, MD PhD, Junji Kato, MD PhD, Masayoshi Kobune, MD PhD

Blood (2018) 132 (Supplement 1): 1519.

https://doi.org/10.1182/blood-2018-99-111124

Published: 2018

Journal Articles

Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.

Blood (2016) 128 (22): 2863.

https://doi.org/10.1182/blood.V128.22.2863.2863

Published: 2016

Journal Articles

CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin

Blood (2016) 128 (22): 2455.

https://doi.org/10.1182/blood.V128.22.2455.2455

Published: 2016

Journal Articles

Next Generation Sequencing of CD138+ Myeloma Cells Could Predict Response Rate and Appropriate Therapy at Diagnosis

Hiroshi Ikeda, MD PhD, Yasushi Sasaki, MDPhD, Soushi Ibata, MD PhD, Masahiro Yoshida, MD, Ayumi Tatekoshi, Satoshi Iyama, MD PhD, Kazuyuki Murase, MD PhD, Kohichi Takada, MD PhD, Shohei Kikuchi, MD PhD, Tsutomu Sato, MD PhD, Masayoshi Kobune, MD PhD, Junji Kato, MD PhD

Blood (2016) 128 (22): 5609.

https://doi.org/10.1182/blood.V128.22.5609.5609

Published: 2016

Journal Articles

Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

Hiroto Horiguchi, MD, Masayoshi Kobune, MD PhD, Shohei Kikuchi, MD PhD, Wataru Jomen, MD, Kazuyuki Murase, MD PhD, Soushi Ibata, MD, Satoshi Iyama, MD PhD, Tsutomu Sato, MD PhD, Yusuke Kamihara, MD, Koji Miyanishi, MD PhD, Yasushi Sato, MD PhD, Tsuyoshi Hayashi, MD PhD, Rishu Takimoto, MD PhD, Junji Kato, MD PhD

Blood (2014) 124 (21): 4627.

https://doi.org/10.1182/blood.V124.21.4627.4627

Published: 2014

Journal Articles

Iron Chelation Therapy Could Rapidly Reduce Oxidative DNA Damage In CD34+ Hematopoietic Cells Before Decrease Of Serum Ferritin Level

Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Hiroto Horiguchi, MD, Yusuke Kamihara, MD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2013) 122 (21): 959.

https://doi.org/10.1182/blood.V122.21.959.959

Published: 2013

Journal Articles

Myelodysplastic Syndrome-Derived Stromal Cells Support Leukemia-Initiating Cells and Contradirectly Eliminate Normal CD34+ Clonogenic Cells

Hiroto Horiguchi, MD, Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Yusuke Kamihara, MD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2013) 122 (21): 1219.

https://doi.org/10.1182/blood.V122.21.1219.1219

Published: 2013

Journal Articles

Analysis Of Hematological Improvement With Iron Chelation Therapy Using Deferasirox In Subject Ts With Therapy-Refractory Severe Aplastic Anemia

Wataru Jomen, MD, Hiroyuki Kuroda, MD, Masahiro Yoshida, MD, Michiko Yamada, MD, Tomoyuki Abe, MD, Tamaki Sakurai, MD, Shigeyuki Fujii, MD, Masahiro Maeda, MD, Miri Fujita, MD, Teppei Matsuno, MD, Masanori Sato, MD, Masayoshi Kobune, MD, PhD, Junji Kato, MD, PhD

Blood (2013) 122 (21): 4878.

https://doi.org/10.1182/blood.V122.21.4878.4878

Published: 2013

Journal Articles

Stromal Cells Expressing Hedgehog-Interacting Protein Are One of the Main Regulators of the Hedgehog Signaling System in Myeloid Neoplasms

Masayoshi Kobune, MD, PhD, Hiroto Horiguchi, MD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Yusuke Kamihara, MD, Yutaka Kawano, MD, PhD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2012) 120 (21): 3840.

https://doi.org/10.1182/blood.V120.21.3840.3840

Published: 2012

Journal Articles

Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells

Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2010) 116 (21): 3211.

https://doi.org/10.1182/blood.V116.21.3211.3211

Published: 2010

Journal Articles

CD34+ Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Shohei Kikuchi, MD., Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Yutaka Kawano, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2009) 114 (22): 1439.

https://doi.org/10.1182/blood.V114.22.1439.1439

Published: 2009

Journal Articles

Cyclopamine Induced Apoptosis in Primary CD34+ Acute Leukemic Cells.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Rishu Takimoto, MD, PhD, Yutaka Kawano, MD, PhD, Shohei Kikuchi, MD., Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Junji Kato, MD, PhD

Blood (2009) 114 (22): 3768.

https://doi.org/10.1182/blood.V114.22.3768.3768

Published: 2009

Journal Articles

Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+ Leukemic Cells.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Yutaka Kawano, MD, PhD, Shohei Kikuchi, MD, PhD, Koji Miyanishi, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2008) 112 (11): 1611.

https://doi.org/10.1182/blood.V112.11.1611.1611

Published: 2008

Journal Articles

Wnt3 Signaling Augments integrinβ1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner.

Blood (2008) 112 (11): 1698.

https://doi.org/10.1182/blood.V112.11.1698.1698

Published: 2008

Journal Articles

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Wnt Signaling.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Shohei Kikuchi, MD, PhD, Yutaka Kawano, MD, PhD, Kohichi Takada, MD, PhD, Koji Miyanishi, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD

Blood (2008) 112 (11): 2325.

https://doi.org/10.1182/blood.V112.11.2325.2325

Published: 2008

Journal Articles

Adenoviral Vector-Mediated Transfer of the Indian Hedgehog Gene Modulates Lymphomyelopoiesis In Vivo .

Masayoshi Kobune, MD, PhD, Yutaka Kawano, MD, PhD, Katsunori Sasaki, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD, Hirofumi Hamada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2007) 110 (11): 2205.

https://doi.org/10.1182/blood.V110.11.2205.2205

Published: 2007

Journal Articles

Wnt3 / RhoA / ROCK Signaling Pathway Is Involved in VLA6-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma.

Masayoshi Kobune, MD, PhD, Yutaka Kawano, MD, PhD, Rishu Takimoto, MD, PhD, Takuya Matsunaga, MD, PhD, Junji Kato, MD, PhD, Hirofumi Hamada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2007) 110 (11): 2518.

https://doi.org/10.1182/blood.V110.11.2518.2518

Published: 2007

Journal Articles

Treatment of Idiopathic Myelofibrosis Employing siRNA for Heat Shock Protein 47 (siRNA/HSP47) Encapsulated in Liposomes.

Junichi Watanabe, MD, Takuya Matsunaga, MD, PhD, Kazuyuki Murase, MD, PhD, Yasushi Sato, MD, PhD, Taiko Nagaya, Hirotoshi Ishiwatari, MD, Sho Takahashi, MD, PhD, Koichi Takada, MD, PhD, Masayoshi Kobune, MD, PhD, Kazuya Shimoda, MD, PhD, Mine Harada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2007) 110 (11): 4646.

https://doi.org/10.1182/blood.V110.11.4646.4646

Published: 2007

Journal Articles

Ex Vivo Large Scale Generation of Human Platelets from Cord Blood CD34+ Cells.

Takuya Matsunaga, MD, PhD, Ikuta Tanaka, MD, PhD, Masayoshi Kobune, MD, PhD, Yutaka Kawano, MD, PhD, Maki Tanaka, MD, PhD, Takehide Akiyama, MD, Kageaki Kuribayashi, MD, PhD, Takafumi Ninomiya, PhD, Hirofumi Hamada, MD, PhD, Yoshiro Niitsu, MD, PhD

Blood (2005) 106 (11): 1892.

https://doi.org/10.1182/blood.V106.11.1892.1892

Published: 2005

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CD34+ Positive Myelodysplastic Cells with Ring Sideroblasts or SF3B1 Mutation Produce High Erythroferrone and GDF15

Extravesicular Mir-7977 Released from Leukemic Cells Inhibites the PCBP1-Mediated mRNA Stabilization and Hippo-YAP Signaling Pathway in Bone Marrow Mesenchymal Stromal Cells

Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.

CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin

Next Generation Sequencing of CD138+ Myeloma Cells Could Predict Response Rate and Appropriate Therapy at Diagnosis

Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

Iron Chelation Therapy Could Rapidly Reduce Oxidative DNA Damage In CD34+ Hematopoietic Cells Before Decrease Of Serum Ferritin Level

Myelodysplastic Syndrome-Derived Stromal Cells Support Leukemia-Initiating Cells and Contradirectly Eliminate Normal CD34+ Clonogenic Cells

Analysis Of Hematological Improvement With Iron Chelation Therapy Using Deferasirox In Subject Ts With Therapy-Refractory Severe Aplastic Anemia

Stromal Cells Expressing Hedgehog-Interacting Protein Are One of the Main Regulators of the Hedgehog Signaling System in Myeloid Neoplasms

Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells

CD34+ Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Cyclopamine Induced Apoptosis in Primary CD34+ Acute Leukemic Cells.

Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+ Leukemic Cells.

Wnt3 Signaling Augments integrinβ1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner.

Interaction with Human Stromal Cells Enhances CXCR4 Expression and Engraftment of Cord Blood Lin-CD34-Cells Via Wnt Signaling.

Adenoviral Vector-Mediated Transfer of the Indian Hedgehog Gene Modulates Lymphomyelopoiesis In Vivo .

Wnt3 / RhoA / ROCK Signaling Pathway Is Involved in VLA6-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma.

Treatment of Idiopathic Myelofibrosis Employing siRNA for Heat Shock Protein 47 (siRNA/HSP47) Encapsulated in Liposomes.

Ex Vivo Large Scale Generation of Human Platelets from Cord Blood CD34+ Cells.

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