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Journal Articles

Large DNA Methylation Canyons Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Mira Jeong, PhD, Xiangfan Huang, Xiaotian Zhang, PhDBS, Jianzhong Su, Muhammad S Shamim, Ivan D Bochkov, Jaime M. Reyes, BS, Haiyoung Jung, Emily Beth Heikamp, MD PhD MSc, Aviva P Aiden, Wei Li, Erez Lieberman Aiden, Margaret A. Goodell, PhD

Blood (2018) 132 (Supplement 1): 534.

https://doi.org/10.1182/blood-2018-99-119485

Published: 2018

Journal Articles

Antibiotics Treatment Ameliorates TET2 Loss of Function Associated Hematological Malignancies

Hongxiang Zeng, PhD, Hailan He, MS, Jia Li, PhD, Wei Han, MS, Anna Guzman, Deqiang Sun, PhD, Katherine Y. King, MD PhD, Margaret A. Goodell, PhD, Yun Huang, PhD

Blood (2018) 132 (Supplement 1): 2610.

https://doi.org/10.1182/blood-2018-99-116424

Published: 2018

Journal Articles

Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells

Yong Lei, PhD, Margaret A. Goodell, PhD

Blood (2018) 132 (Supplement 1): 2571.

https://doi.org/10.1182/blood-2018-99-116841

Published: 2018

Journal Articles

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Etienne De Braekeleer, PhD MSc, Joanne Hsu, BS, Celine Hervieu, MSc, Konstantinos Tzelepis, PhD, Stefano Indraccolo, MD, Alan J. Warren, PhD FRCP, FRCPath, Irmela Jeremias, MD PhD, David Fernandez Antoran, PhD, Phil H Jones, PhD, Margaret A. Goodell, PhD, George S. Vassiliou

Blood (2018) 132 (Supplement 1): 2615.

https://doi.org/10.1182/blood-2018-99-118827

Published: 2018

Journal Articles

Nearly a Third of Clonal Hematopoiesis-Associated DNMT3A Mutations Reduce Protein Stability and May be Associated with Poorer Prognosis

Yung-Hsin Huang, Ayala Tovy, PhD, Venkatasubramaniam Sundaramurthy, Jianzhong Su, Joanne Hsu, BS, Lian He, Anna Guzman, Yubin Zhou, Alexander Meissner, PhD, Wei Li, Margaret A. Goodell, PhD

Blood (2018) 132 (Supplement 1): 1315.

https://doi.org/10.1182/blood-2018-99-115275

Published: 2018

Journal Articles

Precise Modeling of IKZF1 Alterations in Human B-Cell Acute Lymphoblastic Leukemia Cell Lines Reveals Distinct Chemosensitivity, Homing, and Engraftment Properties

Jason H. Rogers, MS, Rohit Gupta, BS, Jaime M. Reyes, BS, Lorenzo Brunetti, MD PhD, Michael C. Gundry, BS, Tidie Song, Cade Johnson, Carlo D. D. Cristobal, BS, Margaret A. Goodell, PhD, Rachel E. Rau, MD

Blood (2018) 132 (Supplement 1): 549.

https://doi.org/10.1182/blood-2018-99-113056

Published: 2018

Journal Articles

Crispr Engineering in CD34+ Progenitors Reveals Cis-Acting Regulatory Regions Mediating 3D Interactions and Stem Cell Fate Decisions

Mira Jeong, PhD, Yong Lei, PhD, Ivan Bochkov, Muhammad S Shamim, B.S., Anna G Guzman, Su-Chen Huang, M.S., Olga Dudchenko, PhD, Ido Machol, Michael C Gundry, BS, Huthayfa Mujahed, MS.c, Soren Lehmann, Erez S Lieberman, PhD, Margaret A Goodell, PhD

Blood (2016) 128 (22): 1466.

https://doi.org/10.1182/blood.V128.22.1466.1466

Published: 2016

Journal Articles

DNA Epigenome Editing Using Crispr-Cas Suntag-Directed DNMT3A

Yung-Hsin Huang, BS, Su Jianzhong, PhD, Yong Lei, PhD, Michael C Gundry, BS, Xiaotian Zhang, BS, Mira Jeong, PhD, Wei Li, PhD, Margaret A Goodell, PhD

Blood (2016) 128 (22): 2707.

https://doi.org/10.1182/blood.V128.22.2707.2707

Published: 2016

Journal Articles

CRLF2 Overexpression Demonstrates Enhanced Leukemogenicity in Down Syndrome Hematopoietic Cells

Jacob J. Junco, PhD BS, Shan Liang, BS, Vishal Gokani, B.S., Vincent Ulysses Gant, PhD BS, Jaime Munoz, B.S., Allison Mayle, PhD, Chun Shik Park, PhD, H. Daniel Lacorazza, PhD, Margaret A Goodell, PhD, Karen R. Rabin, MD PhD

Blood (2016) 128 (22): 2708.

https://doi.org/10.1182/blood.V128.22.2708.2708

Published: 2016

Journal Articles

Regulation of Hematopoietic Stem Cells by Interferons and by DNA Methylation: Implications for Bone Marrow Failure

Margaret A. Goodell, PhD

Blood (2014) 124 (21): SCI-20.

https://doi.org/10.1182/blood.V124.21.SCI-20.SCI-20

Published: 2014

Journal Articles

DOT1L As a Therapeutic Target for the Treatment of DNMT3A -Mutant Acute Myeloid Leukemia

Rachel E. Rau, MD, Min Luo, PhD, Benjamin Rodriguez, PhDBA, Mira Jeong, PhD, Allison Rosen, M.S., Lishing Deng, Yongcheng Song, PhD, Margaret A Goodell, PhD

Blood (2014) 124 (21): 614.

https://doi.org/10.1182/blood.V124.21.614.614

Published: 2014

Journal Articles

Dnmt3a and Tet2 interact to Repress differentiation lineage-specific transcriptional factors in Hematopoietic Stem Cells By the Regulation of Epigenome

Xiaotian Zhang, BS, Mira Jeong, PhD, Jianzhong Su, Myung Gon Ko, PhD, Yun Huang, PhD, Hyun Jung Park, Anjana Rao, PhD, Wei Li, PhD, Margaret A. Goodell, PhD

Blood (2014) 124 (21): 242.

https://doi.org/10.1182/blood.V124.21.242.242

Published: 2014

Journal Articles

Mixed Phenotype Acute Leukemia (MPAL) Has a High Frequency of Mutations in Epigenetic Regulatory Genes: Results from Whole Exome Sequencing

Olive S. Eckstein, MD, Linghua Wang, MD PhD, Jyotinder N. Punia, MD, Steven M. Kornblau, MD, Michael Andreef, MD PhD, David A. Wheeler, PhD, Margaret A. Goodell, PhD

Blood (2014) 124 (21): 3560.

https://doi.org/10.1182/blood.V124.21.3560.3560

Published: 2014

Journal Articles

Long Non-Coding RNAs Control Hematopoietic Stem Cells (HSC) Function

Min Luo, Ph.D., Mira Jeong, Ph.D., Deqiang Sun, Ph.D., Hyun-Jung Park, PhD, Liubin Yang, Hui Wang, Ph.D., Rui Chen, Ph.D., Gretchen Darlington, Ph.D., Wei Li, Ph.D., Margaret A. Goodell, PhD

Blood (2013) 122 (21): 48.

https://doi.org/10.1182/blood.V122.21.48.48

Published: 2013

Journal Articles

Combined Effect Of Dnmt3a Loss-Of-Function and Idh2 neomorphic mutation Promotes Hematopoietic Malignancy

Xiaotian Zhang, B.S, Ting Zhou, M.D., Putluri Nagireddy, PhD, George Michailidis, PhD, Mira Jeong, Ph.D., Arun Sreekumar, PhD, Vivienne I. Rebel, MD, PhD, Margaret A. Goodell, PhD

Blood (2013) 122 (21): 884.

https://doi.org/10.1182/blood.V122.21.884.884

Published: 2013

Journal Articles

Dnmt3b Has Few Specific Functions In Adult Hematopoietic Stem Cells But Shows Abnormal Activity In The Absence Of Dnmt3a

Grant A Challen, PhD, Allison Mayle, Deqiang Sun, Mira Jeong, Ph.D., Min Luo, Ph.D., Wei Li, Ph.D., Margaret A. Goodell, PhD

Blood (2013) 122 (21): 734.

https://doi.org/10.1182/blood.V122.21.734.734

Published: 2013

Journal Articles

Dnmt3a-Deletion Accelerates FLT3-ITD Malignancies In Mice By Hypomethylation Of Enhancer Sites and Activating Stem Cell Programs; Implications For Therapy

Liubin Yang, Benjamin Rodriguez, Min Luo, Ph.D., Mira Jeong, Ph.D., David Ruau, Choladda V. Curry, MD, Xiaotian Zhang, B.S, Grant A Challen, PhD, Rachel E. Rau, MD, Berthold Gottgens, Ph.D., Wei Li, Ph.D., Margaret A. Goodell, PhD

Blood (2013) 122 (21): 595.

https://doi.org/10.1182/blood.V122.21.595.595

Published: 2013

Journal Articles

Dnmt3a Deletion Predisposes Hematopoietic Stem Cells To Malignant Transformation

Allison Mayle, Liubin Yang, Grant A Challen, PhD, Ting Zhou, M.D., Vivienne I. Rebel, MD, PhD, Margaret A. Goodell, PhD

Blood (2013) 122 (21): 4198.

https://doi.org/10.1182/blood.V122.21.4198.4198

Published: 2013

Journal Articles

Hemopoietic Stem Cells In Polycythemia Vera and Essential Thrombocythemia Have Increased TNF-Alpha That Decreases After Pegylated Interferon-a Therapy, But Not Hydroxyurea, and Correlates With Suppression Of PV and ET Clones

Sabina Swierczek, PhD, Mohamed E Salama, MD, Katherine King, MD, PhD, Andrew Wilson, PhD, Sheryl Tripp, MD, Sherrie L. Perkins, MD, PhD, Margaret A. Goodell, PhD, Josef T. Prchal, MD

Blood (2013) 122 (21): 2827.

https://doi.org/10.1182/blood.V122.21.2827.2827

Published: 2013

Journal Articles

Large Conserved Domains Of Low DNA Methylation Maintained By 5-Hydroxymethycytosine and Dnmt3a

Blood (2013) 122 (21): 2406.

https://doi.org/10.1182/blood.V122.21.2406.2406

Published: 2013

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Large DNA Methylation Canyons Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Antibiotics Treatment Ameliorates TET2 Loss of Function Associated Hematological Malignancies

Polycomb Group Proteins Recruit TET1 to Remove Aberrant DNA Methylation in Murine Embryonic Stem Cells

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Nearly a Third of Clonal Hematopoiesis-Associated DNMT3A Mutations Reduce Protein Stability and May be Associated with Poorer Prognosis

Precise Modeling of IKZF1 Alterations in Human B-Cell Acute Lymphoblastic Leukemia Cell Lines Reveals Distinct Chemosensitivity, Homing, and Engraftment Properties

Crispr Engineering in CD34+ Progenitors Reveals Cis-Acting Regulatory Regions Mediating 3D Interactions and Stem Cell Fate Decisions

DNA Epigenome Editing Using Crispr-Cas Suntag-Directed DNMT3A

CRLF2 Overexpression Demonstrates Enhanced Leukemogenicity in Down Syndrome Hematopoietic Cells

Regulation of Hematopoietic Stem Cells by Interferons and by DNA Methylation: Implications for Bone Marrow Failure

DOT1L As a Therapeutic Target for the Treatment of DNMT3A -Mutant Acute Myeloid Leukemia

Dnmt3a and Tet2 interact to Repress differentiation lineage-specific transcriptional factors in Hematopoietic Stem Cells By the Regulation of Epigenome

Mixed Phenotype Acute Leukemia (MPAL) Has a High Frequency of Mutations in Epigenetic Regulatory Genes: Results from Whole Exome Sequencing

Long Non-Coding RNAs Control Hematopoietic Stem Cells (HSC) Function

Combined Effect Of Dnmt3a Loss-Of-Function and Idh2 neomorphic mutation Promotes Hematopoietic Malignancy

Dnmt3b Has Few Specific Functions In Adult Hematopoietic Stem Cells But Shows Abnormal Activity In The Absence Of Dnmt3a

Dnmt3a-Deletion Accelerates FLT3-ITD Malignancies In Mice By Hypomethylation Of Enhancer Sites and Activating Stem Cell Programs; Implications For Therapy

Dnmt3a Deletion Predisposes Hematopoietic Stem Cells To Malignant Transformation

Hemopoietic Stem Cells In Polycythemia Vera and Essential Thrombocythemia Have Increased TNF-Alpha That Decreases After Pegylated Interferon-a Therapy, But Not Hydroxyurea, and Correlates With Suppression Of PV and ET Clones

Large Conserved Domains Of Low DNA Methylation Maintained By 5-Hydroxymethycytosine and Dnmt3a

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