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Journal Articles

Clinicopathologic Correlates and Natural History of Atypical Chronic Myeloid Leukemia

Guillermo Montalban Bravo, MD, Rashmi Kanagal-Shamanna, MD, Koji Sasaki, MD, Lucia Masarova, MD, Kiran Naqvi, MD MPH, Elias Jabbour, MD, Courtney D. DiNardo, MD MSCE, Koichi Takahashi, MD PhD, Marina Konopleva, MD PhD, Naveen Pemmaraju, MD, Nicholas J. Short, MD, Ghayas C. Issa, MD, Tapan M. Kadia, MD, Farhad Ravandi, MBBS, Naval Daver, MD, Gautam Borthakur, MD, Zeev E. Estrov, MD, Joseph D. Khoury, MD, Sanam Loghavi, MD, Sherry A. Pierce, BSN, BA, Carlos E. Bueso-Ramos, MD PhD, Keyur Patel, MD PhD, Srdan Verstovsek, MD PhD, Hagop M. Kantarjian, MD, Prithviraj Bose, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 54–56.
https://doi.org/10.1182/blood-2020-137176
Published: 2020
Journal Articles

The Comparison of Frontline Lower-Dose Dasatinib 50 Mg/Day to Standard-Dose Dasatinib 100 Mg/Day in Newly Diagnosed Chronic Myeloid Leukemia: A Propensity Score Analysis

Koji Sasaki, MD, Elias Jabbour, MD, Kiran Naqvi, MD MPH, Jeffrey Skinner, MHA, Kristin Anderson, Sara E Dellasala, BS, Musa Yilmaz, MD, Alessandra Ferrajoli, MD, Prithviraj Bose, MD, Philip A. Thompson, MB, MS, Yesid Alvarado, MD, Nitin Jain, MD, Guillermo Garcia-Manero, MD, Koichi Takahashi, MD PhD, Jan A. Burger, MD PhD, Gautam Borthakur, MD, Naveen Pemmaraju, MD, Rita Khouri, Shilpa Paul, PharmD, Sherry A. Pierce, BSN, BA, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–5.
https://doi.org/10.1182/blood-2020-140003
Published: 2020
Journal Articles

Comparison of Hyper-CVAD Plus Ofatumumab to Hyper-CVAD Plus Rituximab in Patients with Newly Diagnosed Philadelphia Chromosome-Negative CD20-Positive B-Cell Acute Lymphoblastic Leukemia: A Propensity Score Analysis

Kiyomi Morita, MDPhD, Koji Sasaki, MD, Guillaume Richard-Carpentier, MD, Marina Konopleva, MD PhD, Xuelin Huang, PhD, Nicholas J. Short, MD, Nitin Jain, MD, Farhad Ravandi, MBBS, Bouthaina S. Dabaja, MD, Naval Daver, MD, Tapan M. Kadia, MD, Yesid Alvarado, MD, Courtney D. DiNardo, MD MSCE, Ghayas C. Issa, MD, Naveen Pemmaraju, MD, Guillermo Garcia-Manero, MD, Srdan Verstovsek, MD PhD, Sa A Wang, MD, Joseph D. Khoury, MD, Jeffrey L. Jorgensen, MD PhD, Richard E. Champlin, MD, Issa F. Khouri, MD, Partow Kebriaei, MD, Heather M. Schroeder, Maria Khouri, Koichi Takahashi, MD PhD, Susan M. O'Brien, MD, Hagop M. Kantarjian, MD, Elias Jabbour, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-142121
Published: 2020
Journal Articles

Prognostic Value of Measurable Residual Disease after Venetoclax and Decitabine in Acute Myeloid Leukemia

Abhishek Maiti, MBBS, Courtney D. DiNardo, MD MSCE, Sa A Wang, MD, Jeffrey L. Jorgensen, MD PhD, Tapan M. Kadia, MD, Naval Daver, MD, Nicholas J. Short, MD, Musa Yilmaz, MD, Naveen Pemmaraju, MD, Gautam Borthakur, MD, Prithviraj Bose, MD, Ghayas C. Issa, MD, Alessandra Ferrajoli, MD, Elias Jabbour, MD, Nitin Jain, MD, Guillermo Garcia-Manero, MD, Maro Ohanian, DO, Koichi Takahashi, MD PhD, Guillermo Montalban-Bravo, MD, Lucia Masarova, MD, Jan A. Burger, MD PhD, Philip A. Thompson, MB, MS, Srdan Verstovsek, MD PhD, Koji Sasaki, MD, Michael Andreeff, MD PhD, Caitlin R. Rausch, PharmD, Kathryn Montalbano, Sherry A. Pierce, BSN, BA, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD, Farhad Ravandi, MBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–25.
https://doi.org/10.1182/blood-2020-138773
Published: 2020
Journal Articles

Phase II Study of CPX-351 Plus Venetoclax in Patients with Acute Myeloid Leukemia (AML)

Tapan M. Kadia, MD, Gautam Borthakur, MD, Koichi Takahashi, MD PhD, Courtney D. DiNardo, MD MSCE, Naval Daver, MD, Naveen Pemmaraju, MD, Elias Jabbour, MD, Nitin Jain, MD, Nicholas J. Short, MD, Wei Qiao, PhD, Lade Adewale, Caitlin R. Rausch, PharmD, Sherry A. Pierce, BSN, BA, Yesid Alvarado, MD, Amin M. Alousi, MD, Uday R. Popat, MD, Issa F. Khouri, MD, Guillermo Garcia-Manero, MD, Marina Konopleva, MD PhD, Jorge E. Cortes, MD, Farhad Ravandi, MBBS, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–22.
https://doi.org/10.1182/blood-2020-142074
Published: 2020
Journal Articles

Outcomes with Sequential FLT3-Inhibitor (FLT3i) Based Therapies in Patients (pts) with FLT3 -Mutated Acute Myeloid Leukemia (AML) Exposed to Prior FLT3i Based Therapies

Musa Yilmaz, MD, Mansour Alfayez, Tapan M. Kadia, MD, Courtney D. DiNardo, MD MSCE, Gautam Borthakur, MD, Sanam Loghavi, MD, Marina Konopleva, MD PhD, Rashmi Kanagal-Shamanna, MD, Keyur Patel, MD PhD, Elias Jabbour, MD, Guillermo Garcia-Manero, MD, Naveen Pemmaraju, MD, Sherry A. Pierce, BSN, BA, Ghayas C. Issa, MD, Nicholas J. Short, MD, Guillermo Montalban Bravo, MD, Koichi Takahashi, MD PhD, Rita Assi, MD, Ahmad S Alotaibi, Michael Andreeff, MD PhD, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, Farhad Ravandi, MBBS, Naval Daver, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–24.
https://doi.org/10.1182/blood-2020-139476
Published: 2020
Journal Articles

Overcoming NOTCH1-Driven Chemoresistance in T-Cell Acute Lymphoblastic Leukemia Via Metabolic Intervention with Oxphos Inhibitor

Natalia Baran, PhDMD, Alessia Lodi, PhD, Yogesh Dhungana, PhD, Shannon RENEE Sweeney, PhD, Pandey Renu, PhD, Shelley Herbrich, PhD, Fieke W Hoff, BSc, Anna Skwarska, PhD, Mecit Kaplan, MS, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, MSc, Marc Warmoes, PhD, Shanti Rojas-Sutterlin, PhD, Andre Haman, PhD, Diogo Troggian Veiga, PhD, Ken Furudate, DDM, PhD, Helen Ma, MS, Karine Harutyunyan, PhD, Wentao Yang, Mihai Gagea, MDPhD, Di Du, PhD, May Daher, Luciana Melo Garcia, MD, Sujan Piya, PhD, Vivian Ruvolo, MS, Sriram Shanmugavelandy, Ningping Feng, PhD, Jason P Gay, MS, Ondrej Havranek, MDPhD, Jared Henderson, MS, Katarzyna Tomczak, PhD, Marcin Kaminski, PhD, Daniel Herranz, PharmD, Adolfo Ferrando, MD, PhD, Elias Jabbour, MD, Maria E Di Francesco, PhD, David T. Teachey, MD, Terzah M. Horton, MD PhD, Katayoun Rezvani, MD PhD, Jun J. Yang, PhD, Steven M. Kornblau, MD, Eric Davis, MD, Koichi Takahashi, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Philip Lorenzi, PhD, Jiyang Yu, PhD, Stefano Tiziani, PhD, Trang Hoang, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–20.
https://doi.org/10.1182/blood-2020-136801
Published: 2020
Journal Articles

Response Patterns and MRD By Flow Cytometry and NGS in Patients with Mutant-IDH Acute Myeloid Leukemia Treated with Venetoclax in Combination with Hypomethylating Agents

Danielle Hammond, MD, Sanam Loghavi, MD, Marina Konopleva, MD PhD, Tapan M. Kadia, MD, Naval Daver, MD, Maro Ohanian, DO, Ghayas C. Issa, MD, Yesid Alvarado, MD, Guillermo Montalban-Bravo, MD, Guillermo Garcia-Manero, MD, Gautam Borthakur, MD, Farhad Ravandi, MBBS, Koichi Takahashi, MD PhD, Hagop M. Kantarjian, MD, Courtney D. DiNardo, MD MSCE
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-141380
Published: 2020
Journal Articles

Outcomes of TP53 -Mutant Acute Myeloid Leukemia with Venetoclax and Decitabine

Kunhwa Kim, MDMPH, Abhishek Maiti, MBBS, Tapan M. Kadia, MD, Farhad Ravandi, MBBS, Naval Daver, MD, Naveen Pemmaraju, MD, Gautam Borthakur, MD, Prithviraj Bose, MD, Ghayas C. Issa, MD, Nicholas J. Short, MD, Musa Yilmaz, MD, Yesid Alvarado, MD, Alessandra Ferrajoli, MD, Elias Jabbour, MD, Nitin Jain, MD, Maro Ohanian, DO, Koichi Takahashi, MD PhD, Philip A. Thompson, MB, MS, Caitlin R. Rausch, PharmD, Kathryn Montalbano, Sherry A. Pierce, BSN, BA, Keyur P. Patel, MBBS, PhD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Courtney D. DiNardo, MD MSCE, Marina Konopleva, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–36.
https://doi.org/10.1182/blood-2020-140182
Published: 2020
Journal Articles

Single-Cell Characterization of Acute Myeloid Leukemia (AML) and Its Microenvironment Identifies Signatures of Resistance to PD-1 Blockade Based Therapy

Hussein A Abbas, MDPhD, Dapeng Hao, Katarzyna Tomczak, PhD, Praveen Barrodia, Jin S. Im, Patrick K Reville, MD, Zoe Alaniz, Wei Wang, MD PhD, Ruiping Wang, PhD, Feng Wang, PhD, Koichi Takahashi, MD PhD, Jing Ning, PhD, Maomao Ding, Jairo A. Matthews, Latasha Little, BS, Jianhua Zhang, PhD, Sreyashi Basu, PhD, Courtney D. DiNardo, MD MSCE, Tapan M. Kadia, MD, Farhad Ravandi, MBBS, Gautam Borthakur, MD, Marina Konopleva, MD PhD, Guillermo Garcia-Manero, MD, Michael R Green, PhD, Gheath Alatrash, Padmanee Sharma, James P Allison, PhD, Steven M. Kornblau, MD, Kunal Rai, Linghua Wang, PhD, P Andrew Futreal, PhD, Naval Daver, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–31.
https://doi.org/10.1182/blood-2020-137335
Published: 2020
Journal Articles

Phase II Study of Venetoclax Added to Cladribine + Low Dose AraC (LDAC) Alternating with 5-Azacytidine Demonstrates High Rates of Minimal Residual Disease (MRD) Negative Complete Remissions (CR) and Excellent Tolerability in Older Patients with Newly Diagnosed Acute Myeloid Leukemia (AML)

Tapan M. Kadia, MD, Gautam Borthakur, MD, Naveen Pemmaraju, MD, Naval Daver, MD, Courtney D. DiNardo, MD MSCE, Koji Sasaki, MD, Ghayas C. Issa, MD, Maro Ohanian, DO, Guillermo Montalban Bravo, MD, Nicholas J. Short, MD, Nitin Jain, MD, Alessandra Ferrajoli, MD, Kapil N. Bhalla, MD, Elias Jabbour, MD, Rashmi Kanagal-Shamanna, MD, Koichi Takahashi, MD PhD, Rashmi Malla, RN, BSN, Kelly Marek, Mark Brandt, BS, Uday R. Popat, MD, Michael Andreeff, MD PhD, Jorge E. Cortes, MD, Guillermo Garcia-Manero, MD, Marina Konopleva, MD PhD, Farhad Ravandi, MBBS, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–19.
https://doi.org/10.1182/blood-2020-142092
Published: 2020
Journal Articles

Prognostic and Therapeutic Implications of Mutant TP53 Variant Allelic Frequency in Adults with Newly Diagnosed TP53 -Mutated Acute Myeloid Leukemia

Nicholas J. Short, MD, Guillermo Montalban-Bravo, MD, Hyunsoo Hwang, Jing Ning, PhD, Miguel Franquiz, Rashmi Kanagal-Shamanna, MD, Keyur Patel, MD PhD, Courtney D. Dinardo, MDMSc, Farhad Ravandi, MBBS, Guillermo Garcia-Manero, MD, Koichi Takahashi, MD PhD, Marina Konopleva, MD PhD, Naval Daver, MD, Elias Jabbour, MD, Musa Yilmaz, MD, Ghayas C. Issa, MD, Michael Andreeff, MD PhD, Tapan M. Kadia, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-134312
Published: 2020
Journal Articles

Interim Analysis of the Phase 1b/2 Study of the BCL-2 Inhibitor Venetoclax in Combination with Standard Intensive AML Induction/Consolidation Therapy with FLAG-IDA in Patients with Newly Diagnosed or Relapsed/Refractory AML

Curtis Lachowiez, MD, Marina Konopleva, MD PhD, Tapan M. Kadia, MD, Naval Daver, MD, Sanam Loghavi, MD, Sa A Wang, MD, Maria Adeoti, R.N., Sherry A. Pierce, BSN, BA, Koichi Takahashi, MD PhD, Nicholas J. Short, MD, Koji Sasaki, MD, Gautam Borthakur, MD, Ghayas C. Issa, MD, William G. Wierda, MD PhD, Naveen Pemmaraju, MD, Guillermo Montalban Bravo, MD, Alessandra Ferrajoli, MD, Nitin Jain, MD, Lucia Masarova, MD, Musa Yilmaz, MD, Elias Jabbour, MD, Guillermo Garcia-Manero, MD, Steven M. Kornblau, MD, Farhad Ravandi, MBBS, Hagop M. Kantarjian, MD, Courtney D. Dinardo, MDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–20.
https://doi.org/10.1182/blood-2020-134300
Published: 2020
Journal Articles

Prognostic Significance of Genetic Alterations in Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated with Hyper-CVAD Plus Dasatinib or Hyper-CVAD Plus Ponatinib

Yuya Sasaki, MDPhD, Hagop M. Kantarjian, MD, Nicholas J. Short, MD, Nitin Jain, MD, Koji Sasaki, MD, Farhad Ravandi, MBBS, Marina Konopleva, MD PhD, Guillermo Garcia-Manero, MD, Latasha Little, BS, Curtis Gumbs, Li Zhao, PhD, P Andrew Futreal, PhD, Feng Wang, PhD, Ken Furudate, DDM, PhD, Rebecca Garris, MSc, Koichi Takahashi, MD PhD, Elias Jabbour, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-136676
Published: 2020
Journal Articles

Outcomes of Chronic Myelomonocytic Leukemia (CMML) after Hypomethylating Agent (HMA) Failure

Veronia Guerra, Jorge M. Ramos Perez, MD, Danielle Hammond, MD, Kelly S. Chien, MD, Rashmi Kanagal-Shamanna, MD, Kiran Naqvi, MD MPH, Koji Sasaki, MD, Shilpa Paul, PharmD, Tapan M. Kadia, MD, Courtney D. DiNardo, MD MSCE, Marina Konopleva, MD PhD, Naval Daver, MD, Farhad Ravandi, MBBS, Naveen Pemmaraju, MD, Nicholas J. Short, MD, Ghayas C. Issa, MD, Koichi Takahashi, MD PhD, Zeev E. Estrov, MD, Sherry A. Pierce, BSN, BA, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD, Guillermo Montalban Bravo, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-139901
Published: 2020
Journal Articles

Immunologic Predictors for Clinical Responses in Patients with Myelodysplastic Syndromes Treated with Immune Checkpoint Blockade

Sung-Eun Lee, MD PhD, Feng Wang, PhD, Abel Trujillo-Ocampo, PhDMS, Wilfredo Ruiz Vazquez, Hyun-Woo Cho, Koichi Takahashi, MD PhD, Gheath Alatrash, Jeffrey J. Molldrem, Richard E. Champlin, MD, Naval Daver, MD, Hagop M. Kantarjian, MD, P. Andrew Futreal, Guillermo Garcia-Manero, MD, Jin S. Im
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-136963
Published: 2020
Journal Articles

Long-Term Follow up of a Phase II Study of Guadecitabine (SGI-110) in Patients with Higher-Risk Myelodysplastic Syndrome (MDS)

Kiyomi Morita, MDPhD, Guillermo Montalban Bravo, MD, Koji Sasaki, MD, Kristy R. Bodden, Feng Wang, PhD, Prithviraj Bose, MD, Yesid Alvarado, MD, Naval Daver, MD, Gautam Borthakur, MD, Farhad Ravandi, MBBS, Koichi Takahashi, MD PhD, Elias Jabbour, MD, Courtney D. DiNardo, MD MSCE, Naveen Pemmaraju, MD, Tapan M. Kadia, MD, Maro Ohanian, DO, Sherry A. Pierce, BSN, BA, Mohammad Azab, MD MSc, MBA, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-140614
Published: 2020
Journal Articles

Clinical Outcomes and Influence of Mutation Clonal Dominance in Oligomonocytic and Classical Chronic Myelomonocytic Leukemia

Guillermo Montalban Bravo, MD, Rashmi Kanagal-Shamanna, MD, Veronia Guerra, Jorge M. Ramos Perez, MD, Danielle Hammond, MD, Shilpa Paul, PharmD, Kiran Naqvi, MD MPH, Koji Sasaki, MD, Elias Jabbour, MD, Courtney D. DiNardo, MD MSCE, Koichi Takahashi, MD PhD, Marina Konopleva, MD PhD, Naveen Pemmaraju, MD, Tapan M. Kadia, MD, Farhad Ravandi, MBBS, Naval Daver, MD, Gautam Borthakur, MD, Zeev E. Estrov, MD, Joseph D. Khoury, MD, Sanam Loghavi, MD, Sherry A. Pierce, BSN, BA, Carlos E. Bueso-Ramos, MD PhD, Keyur Patel, MD PhD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–29.
https://doi.org/10.1182/blood-2020-137212
Published: 2020
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment for Patients with Chronic Lymphocytic Leukemia (CLL): Focus on MRD Results

Nitin Jain, MD, Michael J. Keating, MBBS, Philip A. Thompson, MB, MS, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Gautam Borthakur, MD, Koichi Takahashi, MD PhD, Zeev E. Estrov, MD, Koji Sasaki, MD, Nathan H Fowler, MD, Tapan M. Kadia, MD, Marina Konopleva, MD PhD, Yesid Alvarado, MD, Musa Yilmaz, MD, Courtney D. DiNardo, MD MSCE, Prithviraj Bose, MD, Maro Ohanian, DO, Naveen Pemmaraju, MD, Elias Jabbour, MD, Rashmi Kanagal-Shamanna, MD, Keyur Patel, MD PhD, Wei Wang, MD PhD, Jeffrey L. Jorgensen, MD PhD, Sa A Wang, MD, Naveen Garg, MD, Xuemei Wang, MS, Chongjuan Wei, PhD, Nichole Cruz, RN, Ana Ayala, RN, William Plunkett, PhD, Hagop M. Kantarjian, MD, Varsha Gandhi, PhD, William G. Wierda, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-142014
Published: 2020
Journal Articles

Azacitidine (AZA) with Nivolumab (Nivo), and AZA with Nivo + Ipilimumab (Ipi) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia: Clinical and Immune Biomarkers of Response

Naval Daver, MD, Sreyashi Basu, PhD, Guillermo Garcia-Manero, MD, Hussein A Abbas, MDPhD, Marina Konopleva, MD PhD, Tapan M. Kadia, MD, Courtney D. DiNardo, MD MSCE, Gautam Borthakur, MD, Ahmad S. Alotaibi, MD, Naveen Pemmaraju, MD, Elias Jabbour, MD, Sherry A. Pierce, BSN, BA, Mark Brandt, BS, Koichi Takahashi, MD PhD, Jing Ning, Steven M. Kornblau, MD, Koji Sasaki, MD, Musa Yilmaz, MD, Ghayas C. Issa, MD, Nicholas J. Short, MD, Jairo A. Matthews, Wilmer Flores, Michael Andreeff, MD PhD, Jorge E. Cortes, MD, Farhad Ravandi, MBBS, James P Allison, PhD, Hagop M. Kantarjian, MD, Padmanee Sharma
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–45.
https://doi.org/10.1182/blood-2020-142824
Published: 2020