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Journal Articles

Eltanexor (KPT-8602), a Second-Generation Selective Inhibitor of Nuclear Export (SINE) Compound, in Patients with Refractory Multiple Myeloma

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Robert Frank Cornell, MD, Adriana C. Rossi, MDMSc, Rachid Baz, MD, Craig C Hofmeister, MDMPH, Chaim Shustik, MD, Joshua R Richter, MD, Christine I Chen, MD FRCP(C), Dan T. Vogl, MD, Erkan Baloglu, William Senapedis, PhD, Joel Ellis, PhD, Tony Williams, MD, Sharon Shacham, PhD MBA, Michael G. Kauffman, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3134.
https://doi.org/10.1182/blood.V130.Suppl_1.3134.3134
Published: 2017
Journal Articles

A Phase 1/2 Study of the Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, KPT-8602, in Patients with Relapsed Refractory Multiple Myeloma

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R. Frank Cornell, MD MS, Adriana C Rossi, MD, MSc, Rachid Baz, MD, Craig C Hofmeister, Chaim Shustik, MD, Joshua R. Richter, MD, Christine Chen, MD, Dan T. Vogl, MD, Sharon Shacham, PhD MBA, Erkan Baloglu, PhD MBA, William Senapedis, PhD, Joel Ellis, PhD, Sharon Friedlander, PhD, Cassandra Choe-Juliak, MD, Christopher L Cubitt, PhD, Joel G Turner, PhD, Daniel Sullivan, MD MS, Michael Kauffman, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4509.
https://doi.org/10.1182/blood.V128.22.4509.4509
Published: 2016
Journal Articles

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

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Julia Etchin, PhD, Alla Berezovskaya, Amy Saur Conway, Weihsu Claire Chen, PhD, Erkan Baloglu, PhD, Yosef Landesman, PhD, William Senapedis, PhD, Joel Ellis, PhD, Dilara McCauley, PhD, Richard M. Stone, MD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Michael Kauffman, Sharon Shacham, Jean C.Y. Wang, MDPhD, A. Thomas Look, MD
Journal: Blood
Blood (2015) 126 (23): 326.
https://doi.org/10.1182/blood.V126.23.326.326
Published: 2015
Journal Articles

Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination with Fludarabine and Cytarabine in Pediatric Patients with Relapsed or Refractory AML

Free
Jeffrey E Rubnitz, MD PhD, Ronda Kaufman, PhD, Raul C. Ribeiro, MD, Boris Klebanov, MA, MS, Joel Ellis, PhD, Yosef Landesman, PhD, Hagop Youssoufian, MD, Tami Rashal, MD, Sharon Shacham
Journal: Blood
Blood (2015) 126 (23): 1345.
https://doi.org/10.1182/blood.V126.23.1345.1345
Published: 2015
Journal Articles

Development of a Pharmacodynamic Assay for XPO1 Occupancy Using Fluorescence Cross Correlation Spectroscopy (FCCS)

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Marsha L. Crochiere, PhD, Stefan Hannus, PhD, Kerrin Hansen, Frank Becker, PhD, Joel Ellis, PhD, Margaret S. Lee, PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2015) 126 (23): 2487.
https://doi.org/10.1182/blood.V126.23.2487.2487
Published: 2015
Journal Articles

Novel Selective Orally Bioavailable Small Molecule PAK4 Allosteric Modulators (PAMs) Display Anti-Tumor Activity in Vitro and in Vivo in Hematological Malignancies

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William Senapedis, PhD, Ryan George, PhD, Dilara McCauley, PhD, Joel Ellis, PhD, Marsha Crochiere, PhD, Michael Savona, MD, Sharon Shacham, PhD MBA, Yosef Landesman, PhD, Erkan Baloglu, PhD
Journal: Blood
Blood (2014) 124 (21): 2208.
https://doi.org/10.1182/blood.V124.21.2208.2208
Published: 2014