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Ismael Samudio, PhD
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Journal Articles

Mapping Microenvironment-Mediated Signaling Dependency of Targeted Inhibitors: A Mechanism-Based Approach of Selecting Effective Therapy Targeting Drug Resistant AML

Zhihong Zeng, MD, Wenbin Liu, PhD, Twee Tsao, MS, Yihua Qiu, MD, Ismael Samudio, PhD, Keith Baggerly, PhD, Steven M. Kornblau, MD, Hagop M Kantarjian, MD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1398.
https://doi.org/10.1182/blood.V126.23.1398.1398
Published: 2015
Journal Articles

Bone Marrow Adipocyte-Derived Free Fatty Acids Induce Gene Signature Linking Transcription with Metabolic Changes That Contribute to Survival of Acute Monocytic Leukemia Cells

Yoko Tabe, MD PhD, Masako Harada, PhD, Yuka Miyamae, Kaoru Mogushi, Saiko Kazuno, Tsutomu Fujimura, Hiromichi Matsushita, MD PhD, Takashi Ueno, Takehiko Yokomizo, MD PhD, Takashi Miida, MD PhD, Ismael Samudio, PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1013.
https://doi.org/10.1182/blood.V124.21.1013.1013
Published: 2014
Journal Articles

Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias

Polina Matre, PhD, Ismael Samudio, PhD, Rodrigo Jacamo, PhD, Ying Wang, Jing Wang, R Eric Davis, Xiaohua Su, Sonja Schindela, Rachel Newman, Jianhua Hu, Torsten Haferlach, MD, Michael Andreeff, MD, PhD, Elsa R. Flores, Aaron Schimmer, PhD, MD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 606.
https://doi.org/10.1182/blood.V122.21.606.606
Published: 2013
Journal Articles

Suppression of Mir-93 May Regulate Anti-Oxidant Metabolism in Mesenchymal Stromal Cells Derived From Acute Myeloid Leukemia Patients.

Peter P. Ruvolo, PhD, Rodrigo Jacamo, PhD, Teresa McQueen, BS, Rongqing Pan, BS, Ismael Samudio, PhD, Marina Konopleva, MD, PhD, Steven M. Kornblau, MD, Ramiro Garzon, MD, Carlo M. Croce, MD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2354.
https://doi.org/10.1182/blood.V120.21.2354.2354
Published: 2012
Journal Articles

The Hypoxic Microenvironment in Acute Myelogenous Leukemia: Critical Role of CXCR4 in the Induction of HIF-1α.

Michael Andreeff, MD, PhD, Martin Dietrich, BS, Paul Corn, MD, PhD, Sergej Konoplev, MD, PhD, Marina Konopleva, MD, PhD, Ismael Samudio, PhD
Journal: Blood
Blood (2007) 110 (11): 1819.
https://doi.org/10.1182/blood.V110.11.1819.1819
Published: 2007
Journal Articles

Synergistic Induction of Apoptosis by Simultaneous Disruption of the Bcl-2 and mTOR/Akt Pathways in Acute Myeloid Leukemia.

Zhihong Zeng, MD, Ismael Samudio, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 1588.
https://doi.org/10.1182/blood.V110.11.1588.1588
Published: 2007
Journal Articles

Novel Small Molecule MDM2 Inhibitor MI-63 Induces p53-Dependent Apoptosis in AML Cell Lines.

Ismael Samudio, PhD, Martin Dietrich, M.D., Paul Corn, M.D.; PhD, Dajun Yang, M.D.,Ph.D, Gautam Borthakur, M.D
Journal: Blood
Blood (2006) 108 (11): 2596.
https://doi.org/10.1182/blood.V108.11.2596.2596
Published: 2006
Journal Articles

Relationship between m-TOR-Mediated Upregulation of Glycolysis, Chemoresistance, and Prognosis in Patients with ALL.

Daniela Buglio, PhD, Marina Konopleva, MD, PhD, Teresa McQueen, BS, Ismael Samudio, PhD, Kristine R. Broglio, MS, BS, Vivian Ruvolo, Rooha Contractor, Wenjing Chen, MS, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD, Mary A. Weiser, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 12.
https://doi.org/10.1182/blood.V106.11.12.12
Published: 2005
Journal Articles

A Novel Mechanism of Action of Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct Permeabilization of the Inner Mitochondrial Membrane To Inhibit Electron Transport and Induce Apoptosis.

Ismael Samudio, PhD, Marina Konopleva, MD, PhD, Helene Pelicano, PhD, Peng Huang, MD, PhD, Olga Frolova, PhD, William Bornmann, PhD, Yun-ming Ying, Randall Evans, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 4462.
https://doi.org/10.1182/blood.V106.11.4462.4462
Published: 2005
Journal Articles

Guggulsterones Induce Apoptosis and Differentiation in AML: Identification of Isomer-Specific Antileukemic Activities of the Pregnanedienedione Structure.

Ismael Samudio, PhD, Marina Konopleva, MD, PhD, Stephen Safe, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 4466.
https://doi.org/10.1182/blood.V106.11.4466.4466
Published: 2005
Journal Articles

Inhibition of Bcl-2 Signaling by Small Molecule BH3 Inhibitor GX15-070 as a Novel Therapeutic Strategy in AML.

Rooha Contractor, Marina Konopleva, MD, PhD, Ismael Samudio, PhD, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 3372.
https://doi.org/10.1182/blood.V106.11.3372.3372
Published: 2005
Journal Articles

Mechanisms of Apoptosis Induction by BH3 Inhibitor ABT-737 in AML.

Michael Andreeff, MD, PhD, Rooha Contractor, Peter P. Ruvolo, PhD, Xingming Deng, MD, PhD, Ismael Samudio, PhD, Yue-Xi Shi, Teresa McQueen, BS, Rui-Yu Wang, MD, PhD, Wendy Schober, Xiaoyang Ling, PhD, Frank C. Marini, PhD, David Harris, Zeev Estrov, MD, James McCubrey, PhD, W. Stratford May, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 244.
https://doi.org/10.1182/blood.V106.11.244.244
Published: 2005
Journal Articles

Mechanisms and Activity of PPARγ-Active Triterpenoids CDDO and CDDO-Me in Leukemias.

Marina Konopleva, MD, PhD, Ismael Samudio, PhD, Twee Tsao, Steven M. Kornblau, MD, Yue-Xi Shi, Teresa McQueen, BS, Rooha Contractor, Michael B. Sporn, MD, Colin J. Meyer, MD, Warren Huff, Stephen H. Safe, PhD, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 2460.
https://doi.org/10.1182/blood.V106.11.2460.2460
Published: 2005