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Hiroyuki Takahashi, MD, PhD
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Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

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Masanori Yoshida, MD, Kazuhiko Nakabayashi, PhD, Aiko Sato-Otsubo, PhD, Shinichi Tsujimoto, MD PhD, Kaoru Yoshida, MD, Ryota Shirai, MD, Tomoo Osumi, MD, Yuki Yuza, MD PhD, Masatoshi Takagi, MD PhD, Hiroyuki Takahashi, MD PhD, Katsuyoshi Koh, MD, Akitoshi Kinoshita, MD PhD, Moeko Hino, MD, Toshihiko Imamura, MD PhD, Yozo Nakazawa, MD PhD, Okuya Mayuko, MD PhD, Harumi Kakuda, MD PhD, Masashi Sanada, MD, Kimikazu Matsumoto, MD, PhD, Daisuke Tomizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Akira Ohara, MD PhD, Atsushi Manabe, MD PhD, Kenichiro Hata, MD PhD, Jun J. Yang, PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2751.
https://doi.org/10.1182/blood-2019-125713
Published: 2019
Journal Articles

Post-Induction Minimal Residual Disease Measured By Flow Cytometry and Deep Sequencing of Mutant GATA1 Are Both Significant Prognostic Factors for Children with Myeloid Leukemia and Down Syndrome: A Nationwide Prospective Study of the Japanese Pediatric Leukemia/Lymphoma Study Group

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Takashi Taga, MD PhD, Shiro Tanaka, PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD, Hidefumi Hiramatsu, MD PhD, Takako Miyamura, MD PhD, Yoshiko Hashii, MD PhD, Daisuke Hasegawa, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Katsuyoshi Koh, MD, Daiichiro Hasegawa, MD PhD, Asahito Hama, MD PhD, Akiko M Saito, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3848.
https://doi.org/10.1182/blood-2019-123302
Published: 2019
Journal Articles

Efficacy and Safety of Autologous Stem Cell Transplantation in Elderly Patients with Multiple Myeloma in the Era of Novel Agents

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Shohei Mizuno, MD PhD, Koji Kawamura, MD PhD, Ichiro Hanamura, MD PhD, Kazutaka Sunami, MD PhD, Takehiko Mori, MD PhD, Fumihiko Nakamura, Shinsuke Iida, MD PhD, Hideyuki Nakazawa, PhD MD, Masanori Makita, Shinichi Kako, MD, Masashi Sawa, MD PhD, Yasunori Ueda, MD PhD, Hiroyuki Takahashi, MD PhD, Yoshinobu Kanda, MD PhD, Tatsuo Ichinohe, MD PhD, Yoshiko Atsuta, MD PhD, Hiroyuki Takamatsu, MD PhD, Akiyoshi Takami, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3437.
https://doi.org/10.1182/blood-2018-99-109905
Published: 2018
Journal Articles

Value of Computed Tomography-Defined Sarcopenia: A Prognostic Predictor of Non-Relapse Mortality Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome

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Taiki Ando, MD, Shin Fujisawa, MD PhD, Takayuki Sakuma, MD, Haruka Teshigawara, MD, Ayako Matsumura, MD, Taisei Suzuki, MD, Hiroshi Teranaka, MD, Akiko Negoro, MD, Eriko Ogusa, MD, Jun Aoki, MD PhD, Kazuho Miyashita, MD PhD, Yoshimi Ishii, MD PhD, Hiroyuki Takahashi, MD PhD, Yuki Nakajima, MD PhD, Takuya Miyazaki, MD PhD, Maki Hagihara, MD PhD, Kenji Matsumoto, MD PhD, Etsuko Yamazaki, MD PhD, Hideaki Nakajima, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4562.
https://doi.org/10.1182/blood.V130.Suppl_1.4562.4562
Published: 2017
Journal Articles

Clinical Impact of Sarcopenia and Skeletal Muscle Mass Change during Chemotherapy on Outcomes of Diffuse Large B-Cell Lymphoma

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Hiroshi Teranaka, MD, Shin Fujisawa, MD PhD, Takayuki Sakuma, MD, Haruka Teshigawara, MD, Ayako Matsumura, MD, Taiki Ando, MD, Taisei Suzuki, MD, Akiko Negoro, MD, Eriko Ogusa, MD, Jun Aoki, MD PhD, Kazuho Miyashita, MD PhD, Yoshimi Ishii, MD PhD, Hiroyuki Takahashi, MD PhD, Yuki Nakajima, MD PhD, Takuya Miyazaki, MD PhD, Maki Hagihara, MD PhD, Kenji Matsumoto, MD PhD, Etsuko Yamazaki, MD PhD, Hideaki Nakajima, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5221.
https://doi.org/10.1182/blood.V130.Suppl_1.5221.5221
Published: 2017
Journal Articles

The Association Between L-Asparaginase Hypersensitivity and Genetic Variants in Japanese Childhood ALL Patients

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Yoichi Tanaka, PhD, Kevin Y Urayama, PhD MPH, Takahisa Kawaguchi, PhD, Makiko Mori, MD, Daisuke Hasegawa, MD PhD, Sae Ishimaru, MD, Yuichi Taneyama, MD PhD, Kazuki Terada, MD, Masakatsu Yanagimachi, MD PhD, Setsuo Ota, MD, Hiroyuki Takahashi, MD PhD, Takeshi Inukai, MD,PhD, Daisuke Toyama, MD, Dai Keino, MD PhD, Koichi Moriwaki, MD, Masatoshi Takagi, MD PhD, Junya Fujimura, MD, Yujin Sekinaka, MD, Kozue Nakamura, MD, Yuya Sato, MD, Keitaro Matsuo, MDPhD, Akira Ohara, MD PhD, Katsuyoshi Koh, MD, Fumihiko Matsuda, MD PhD, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5141.
https://doi.org/10.1182/blood.V128.22.5141.5141
Published: 2016
Journal Articles

High Event-Free Survival Rate with Minimum-Dose-Anthracycline Treatment in Childhood Acute Promyelocytic Leukemia: A Nationwide Prospective Study By the Japanese Pediatric Leukemia / Lymphoma Study Group (JPLSG)

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Hiroyuki Takahashi, MD PhD, Tomoyuki Watanabe, PhD, Akitoshi Kinoshita, MD PhD, Yuki Yuza, MD PhD, Hiroshi Moritake, MD PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD PhD, Hideki Nakayama, MD PhD, Akira Shimada, MD PhD, Kazuko Kudo, MDPhD, Tomohiko Taki, MD PhD, Miharu Yabe, MD PhD, Hiromichi Matsushita, MD PhD, Yuka Yamashita, PhD, Kazutoshi Koike, MD, Atsushi Ogawa, MD, Yoshiyuki Kosaka, MD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Akiko M. Saito, MD PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD PhD, Hayato Miyachi, MD PhD, Akio Tawa, MD PhD, Souichi Adachi, MDPhD
Journal: Blood
Blood (2014) 124 (21): 956.
https://doi.org/10.1182/blood.V124.21.956.956
Published: 2014
Journal Articles

Risk-Oriented Therapy for Myeloid Leukemia of Down Syndrome: A Nationwide Prospective Study By the Japanese Pediatric Leukemia / Lymphoma Study Group (JPLSG)

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Takashi Taga, MD PhD, Tomoyuki Watanabe, Kazuko Kudo, MDPhD, Daisuke Tomizawa, MD PhD, Kiminori Terui, MD PhD, Hiroshi Moritake, MD PhD, Akitoshi Kinoshita, MD PhD, Shotaro Iwamoto, MD PhD, Hideki Nakayama, MD PhD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Hiroaki Goto, MD, PhD, Katsuyoshi Koh, MD, Akiko M. Saito, MD PhD, Keizo Horibe, MD PhD, Tatsutoshi Nakahata, MD PhD, Akio Tawa, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3668.
https://doi.org/10.1182/blood.V124.21.3668.3668
Published: 2014
Journal Articles

Recombinant Thrombomodulin Safely Controls Disseminated Intravascular Coagulopathy in Acute Promyelocytic Leukemia – Results from the Japanese Pediatric Leukemia/Lymphoma Study Group AML-P05 Study

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Yuki Yuza, MD PhD, Hiroyuki Takahashi, MD PhD, Hiroshi Moritake, MD PhD, Kiminori Terui, MD PhD, Daiichiro Hasegawa, MD, Kazutoshi Koike, MD, Atsushi Ogawa, MD, Masami Inoue, MD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Souichi Adachi, MDPhD
Journal: Blood
Blood (2014) 124 (21): 5097.
https://doi.org/10.1182/blood.V124.21.5097.5097
Published: 2014
Journal Articles

Prognostic Impact of Gender in Diffuse Large B Cell Lymphoma Patients Treated with R-CHOP Therapy

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Hiroyuki Takahashi, MD PhD, Naoto Tomita, MD PhD, Yasufumi Ishiyama, MD, Satoshi Koyama, MD, Kazuho Miyashita, MD, Yuki Nakajima, MD, Yukako Hattori, MD, Kenji Motohashi, MD, Hirotaka Takasaki, MD, Rika Kawasaki, MD, Maki Hagihara, MDPhD, Chizuko Hashimoto, MD, Sachiya Takemura, MD, Katsumichi Fujimaki, MD PhD, Jun Taguchi, MD PhD, Rika Sakai, MD PhD, Hiroyuki Fujita, MD PhD, Shin Fujisawa, MD, Hiroshi Harano, MD PhD, Yoshiaki Ishigatsubo, MD PhD
Journal: Blood
Blood (2014) 124 (21): 5391.
https://doi.org/10.1182/blood.V124.21.5391.5391
Published: 2014
Journal Articles

Effect of High Body Mass Index on the Prognosis of Diffuse Large B-Cell Lymphoma

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Yukako Hattori, MD, Naoto Tomita, MD PhD, Taisei Suzuki, MD, Yasufumi Ishiyama, MD, Kumiko Kishimoto, MD, Satoshi Koyama, MD, Hiroyuki Takahashi, MD PhD, Kazuho Miyashita, MD, Yuki Nakajima, MD, Kenji Motohashi, MD, Hirotaka Takasaki, MD, Rika Kawasaki, MD, Chizuko Hashimoto, MD, Katsumichi Fujimaki, MD PhD, Rika Sakai, MD PhD, Shin Fujisawa, MD, Shigeki Motomura, MD PhD, Yoshiaki Ishigatsubo, MD PhD
Journal: Blood
Blood (2014) 124 (21): 5368.
https://doi.org/10.1182/blood.V124.21.5368.5368
Published: 2014
Journal Articles

Outcome of Adolescent and Young Adults with Acute Myeloid Leukemia Treated with Pediatric Protocols: A Report from the 3 Japanese Cooperative Studies

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Daisuke Tomizawa, MD PhD, Tomoyuki Watanabe, PhD, Ryoji Hanada, MD, Keizo Horibe, MD PhD, Yasuo Horikoshi, MD, Shotaro Iwamoto, MD PhD, Akitoshi Kinoshita, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD PhD, Akira Shimada, MD PhD, Takashi Taga, MD PhD, Hiroyuki Takahashi, MD PhD, Akio Tawa, MD PhD, Kiminori Terui, MD PhD, Hiroki Hori, MD, Yoshifumi Kawano, MD PhD, Atsushi Kikuta, MD PhD, Atsushi Manabe, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 374.
https://doi.org/10.1182/blood.V124.21.374.374
Published: 2014
Journal Articles

Significance Of Minimal Residual Disease Detected By Multi-Color Flow Cytometry In Childhood Acute Myeloid Leukemia With The Intermideate-Risk Cytogenetics and Negative FMS-Like Tyrosine Kinase 3 Internal Tandem Duplication: A Report Of The Tokyo Children's Cancer Study Group

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Dai Keino, MD, Akitoshi Kinoshita, MD, PhD, Daisuke Tomizawa, MD, PhD, Hiroyuki Takahashi, MD, PhD, Kohmei Ida, MD, Hidemitsu Kurosawa, MD, Kazutoshi Koike, MD, Setsuo Ota, MD, Noriyuki Iwasaki, MD, Junya Fujimura, MD, Yuki Yuza, MD, Chikako Kiyotani, MD, Shohei Yamamoto, MD, PhD, Tomoo Osumi, MD, Takahiro Ueda, MD, PhD, Shinji Mochizuki, MD, PhD, Keiichi Isoyama, MD, Ryoji Hanada, MD, Akio Tawa, MD, PhD, Akira Kikuchi, MD, PhD, Atsushi Manabe, MD, PhD, Akira Ohara, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1416.
https://doi.org/10.1182/blood.V122.21.1416.1416
Published: 2013
Journal Articles

Serum Beta-2 Microglobulin Level As a Useful Prognostic Marker Of Hodgkin Lymphoma

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Yuki Nakajima, MD, Naoto Tomita, MD, Reina Watanabe, MD, Yasufumi Ishiyama, MD, Eri Yamamoto, MD, Daisuke Ishibashi, MD, Megumi Itabashi, MD, Satoshi Koyama, MD, Hiroyuki Takahashi, MD, PhD, Ayumi Numata, MD, Hirotaka Takasaki, M.D., Rika Kawasaki, Hideyuki Kuwabara, MD, Masatsugu Tanaka, MD, Chizuko Hashimoto, MD, Katsumichi Fujimaki, MD, Rika Sakai, MD, Shigeki Motomura, MD, Yoshiaki Ishigatsubo, MD
Journal: Blood
Blood (2013) 122 (21): 4239.
https://doi.org/10.1182/blood.V122.21.4239.4239
Published: 2013
Journal Articles

Poor Prognosis With Different Induction Rate Was Observed In Children With Acute Myeloid Leukemia and FLT3 -ITD According To The ITD/WT Allelic Ratio: A Result From The Japanese Pediatric Leukemia/Lymphoma Study Group

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Akira Shimada, MD., PhD, Yuka Yamashita, MS, Daisuke Tomizawa, MD, PhD, Akio Tawa, MD, PhD, Tomoyuki Watanabe, PhD, Toshiya Yokozawa, MD, PhD, Kazuko Kudo, MD, PhD, Takashi Taga, MD, PhD, Shotaro Iwamoto, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, PhD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD., PhD, Katsuyoshi Koh, MD, Hiroaki Goto, MD., PhD, Yoshiyuki Kosaka, MD, PhD, Akiko Moriya Saito, MD, PhD, Junichiro Fujimoto, MD, PhD, Keizo Horibe, MD, PhD, Kentaro Oki, MD, PhD, Yasuhide Hayashi, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3891.
https://doi.org/10.1182/blood.V122.21.3891.3891
Published: 2013
Journal Articles

Attempts to Optimize Post-Induction Treatment in Childhood Acute Myeloid Leukemia without Core Binding Factors: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

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Daiichiro Hasegawa, MD, PhD, Akio Tawa, MD, PhD, Daisuke Tomizawa, Tomoyuki Watanabe, PhD, Akiko Saito, MD, PhD, Kazuko Kudo, Takashi Taga, MD, Shotaro Iwamoto, MD, PhD, Akira Shimada, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD, Katsuyoshi Koh, MD, PhD, Hisato Kigasawa, MD, Yoshiyuki Kosaka, MD, PhD, Hayato Miyachi, MD, PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3545.
https://doi.org/10.1182/blood.V120.21.3545.3545
Published: 2012
Journal Articles

Excess Reduction of Anthracyclines Results in Inferior Event-Free Survival in Core Binding Factor Acute Myeloid Leukemia in Children; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

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Daisuke Tomizawa, Akio Tawa, MD, PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD, Kazuko Kudo, Takashi Taga, MD, Shotaro Iwamoto, MD, PhD, Akira Shimada, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD, Katsuyoshi Koh, MD, PhD, Hisato Kigasawa, MD, Yoshiyuki Kosaka, MD, PhD, Hayato Miyachi, MD, PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 409.
https://doi.org/10.1182/blood.V120.21.409.409
Published: 2012
Journal Articles

Prospective Nationwide Observational Study of Hepatitis B Virus (HBV) DNA Monitoring and Preemptive Antiviral Therapy for HBV Reactivation in Patients with B-Cell Non-Hodgkin Lymphoma Following Rituximab Containing Chemotherapy: Results of Interim Analysis.

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Shigeru Kusumoto, MD, PhD, Yasuhito Tanaka, MD, PhD, Ritsuro Suzuki, M.D., Takashi Watanabe, MD, PhD, Masanobu Nakata, MD, Hirotaka Takasaki, MD, Noriyasu Fukushima, MD, PhD, Takuya Fukushima, MD, PhD, Yukiyoshi Moriuchi, MD, Kuniaki Itoh, MD, PhD, Kisato Nosaka, MD, PhD, Ilseung Choi, MD, Masashi Sawa, MD, PhD, Rumiko Okamoto, MD, Hideki Tsujimura, MD, PhD, Toshiki Uchida, MD, PhD, Sachiko Suzuki, MD, PhD, Masataka Okamoto, MD, PhD, Tsutomu Takahashi, MD, PhD, Isamu Sugiura, MD, PhD, Yasushi Onishi, MD, PhD, Mika Kohri, MD, PhD, Shinichiro Yoshida, MD, PhD, Rika Sakai, MD, Minoru Kojima, MD, PhD, Hiroyuki Takahashi, MD, PhD, Akihiro Tomita, MD, PhD, Dai Maruyama, MD, PhD, Yoshiko Atsuta, MD, PhD, Eiji Tanaka, MD, PhD, Takayo Suzuki, MD, PhD, Tomohiro Kinoshita, M.D., Ph.D., Michinori Ogura, MD, PhD, Masashi Mizokami, MD, PhD, Ryuzo Ueda, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2641.
https://doi.org/10.1182/blood.V120.21.2641.2641
Published: 2012
Journal Articles

Serum Ferritin Level As a Prognostic Factor for Patients with Extranodal NK/T-Cell Lymphoma, Nasal Type.

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Etsuko Yamazaki, MD, Naoto Tomita, MD, Satoshi Koyama, MD, Kumiko Kishimoto, MD, Eriko Ogusa, MD, Yoshimi Ishii, MD, Hiroyuki Takahashi, MD, PhD, Kazuho Miyashita, MD, Shiro Matsuura, MD, Takayoshi Tachibana, MD, Hirotaka Takasaki, MD, Sachiya Takemura, MD, Katsumichi Fujimaki, MD, Rika Sakai, MD, Shin Fujisawa, MD, Yoshiaki Ishigatsubo, MD
Journal: Blood
Blood (2012) 120 (21): 2644.
https://doi.org/10.1182/blood.V120.21.2644.2644
Published: 2012
Journal Articles

Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG).

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Daisuke Tomizawa, Akio Tawa, MD, PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD, Kazuko Kudo, Takashi Taga, MD, Shotaro Iwamoto, MD, PhD, Akira Shimada, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD, Katsuyoshi Koh, MD, PhD, Hisato Kigasawa, MD, Yoshiyuki Kosaka, MD, PhD, Hayato Miyachi, MD, PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2615.
https://doi.org/10.1182/blood.V120.21.2615.2615
Published: 2012