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Journal Articles

A Practical, One Clinic Visit, Population Pharmacokinetic (PK) Protocol for Generation of PK Profiles in Subjects with Severe Hemophilia a

Victor S. Blanchette, FRCP, Laura Tiseo, BSc, CCRP, David Lillicrap, MD, Shannon Jackson, MD FRCPC, Massimo Morfini, MD, Vanessa Bouskill, MN, Manuel Carcao, Margaret L. Rand, PhD, Derek Stephens, MSc, Liane Khoo, MD, Ester Zapotocka, MD, Vladimir Komrska, MD, Jan Blatny, MD PhD

Blood (2018) 132 (Supplement 1): 2480.

https://doi.org/10.1182/blood-2018-99-111024

Published: 2018

Journal Articles

The Highly Prevalent Deletions in F8 Intron 13 Found in French Mild Haemophilia a Patients Result of Both Founder Effect and Recurrent De Novo Events

Yohann Jourdy, PhD PharmD, Mathilde Fretigny, PharmD, Fanny Lassalle, PharmD, David Lillicrap, MD, Claude Negrier, Patrice Bouvagnet, MD, Christine Vinciguerra, PharmD

Blood (2018) 132 (Supplement 1): 2489.

https://doi.org/10.1182/blood-2018-99-111791

Published: 2018

Journal Articles

Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease

Karl Desch, MD, Ayse Bilge Ozel, PhD, Matthew Halvorsen, PhD, Alison L. Michels, Laura L Swystun, BSc, PhD, Lauren Mokry, PhD, Brent Richards, Marine Germain, David A. Tregouet, PhD, Pieter H. Reitsma, PhD, Clive Kearon, MB, Jun Z Li, PhD, David B. Goldstein, PhD, David Lillicrap, MD FRCPC, David Ginsburg, MD

Blood (2017) 130 (Supplement 1): 457.

https://doi.org/10.1182/blood.V130.Suppl_1.457.457

Published: 2017

Journal Articles

Immune Tolerance Induction in Hemophilia A Patients Using Wilate® —a Canadian 10 Year Study (PREVAIL)

Paul Moorehead, MD, Mark J. Belletrutti, MD MSc, David Lillicrap, MD FRCPC, Robert J Klaassen, MD FRCPC, Manuel Carcao, MDMSc, Georges E. Rivard, MD FRCPC

Blood (2017) 130 (Supplement 1): 3679.

https://doi.org/10.1182/blood.V130.Suppl_1.3679.3679

Published: 2017

Journal Articles

Does Age Affect Desmopressin Responsiveness in Patients with Von Willebrand Disease?

Nicola Goldberg, MD, Rosane Nisenbaum, PhD, Hong Song, David Lillicrap, MD FRCPC, Jerome M. Teitel, MD FRCPC, Paula D. James, MD, Michelle Sholzberg, MDM, MSc, FRCPC

Blood (2017) 130 (Supplement 1): 3681.

https://doi.org/10.1182/blood.V130.Suppl_1.3681.3681

Published: 2017

Journal Articles

A Novel Von Willebrand Factor Fragment Acts As a Chaperone to Prolong the Half-Life of Recombinant Human FVIII (Simoctocog Alfa) in Hemophilia a Dogs and FVIII/VWF Double Knockout Mice

Barbara A Solecka-Witulska, PhD, David Lillicrap, MD FRCPC, Christine Hough, PhD, Christoph Kannicht, PhD

Blood (2017) 130 (Supplement 1): 178.

https://doi.org/10.1182/blood.V130.Suppl_1.178.178

Published: 2017

Journal Articles

A Factor VIII Fusion with an Inactivated FIX Generates a Biologically Active Molecule with Delayed Clearance in a FVIII/VWF Knockout Mouse Model

Oladipo Jude Akinwale, MSc,BSc, Ian Wilkinson, PhD, Christine Hough, PhD, David Lillicrap, MD FRCPC, Michael Makris, MD, Richard Ross, MD FRCP

Blood (2017) 130 (Supplement 1): 2344.

https://doi.org/10.1182/blood.V130.Suppl_1.2344.2344

Published: 2017

Journal Articles

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

Philip M Zakas, PhD, Caelan Radford, Christine Brown, Courtney Dwyer, RLAT, Christopher B Doering, PhD, Eric A Gaucher, PhD, David Lillicrap, MD FRCPC

Blood (2017) 130 (Supplement 1): 240.

https://doi.org/10.1182/blood.V130.Suppl_1.240.240

Published: 2017

Journal Articles

Differential Glycosylation Between Recombinant Factor VIII Produced in Baby Hamster Kidney and Chinese Hamster Ovary Cells Confers Differences in Immunogenicity in a Humanized Hemophilia Α Mouse Model

Jesse Lai, BSc, Laura L Swystun, PhD, Dominique Cartier, Cunjie Zhang, MSc, Kate Nesbitt, James Dennis, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2016) 128 (22): 326.

https://doi.org/10.1182/blood.V128.22.326.326

Published: 2016

Journal Articles

Development of an Optimized rAAV2/6 Human Factor 8 cDNA Vector Cassette for Hemophilia a Gene Therapy

Blood (2016) 128 (22): 1173.

https://doi.org/10.1182/blood.V128.22.1173.1173

Published: 2016

Journal Articles

VWF-FVIII Interactions Influence Hemostatic Thrombus Stability in Murine Models of Hemophilia Α and Type 2N VWD

Laura L Swystun, PhD, Courtney Dwyer, Kate Nesbitt, Kassandra Hebert, David Lillicrap, MD

Blood (2016) 128 (22): 1403.

https://doi.org/10.1182/blood.V128.22.1403.1403

Published: 2016

Journal Articles

Histones Induce Endothelial Von Willebrand Factor Release and Subsequent Platelet Capture in In Vitro and In Vivo Models

Alison Michels, BSc, Laura L Swystun, PhD, Silvia Albánez, MSc, Jeffrey Mewburn, Kate Sponagle, David Lillicrap, MD

Blood (2014) 124 (21): 2768.

https://doi.org/10.1182/blood.V124.21.2768.2768

Published: 2014

Journal Articles

Immunization Against Influenza but Not MMR Modulates the Anti-Factor VIII Immune Response in Hemophilia Α Mice

Jesse Lai, BSc, Paul C. Moorehead, MDMS, MSc, Kate Sponagle, Katharina Nora Steinitz, PhD, Birgit M Reipert, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2014) 124 (21): 1501.

https://doi.org/10.1182/blood.V124.21.1501.1501

Published: 2014

Journal Articles

Administration of Dexamethasone during Initial Exposure to Factor VIII Induces Durable and Antigen-Specific Tolerance to Factor VIII in Hemophilia Α Mice with a Humanized Major Histocompatibility Complex II Transgene

Paul C. Moorehead, MDMS, MSc, Maria T. Georgescu, BScH, Alice S. van Velzen, MD, Kate Sponagle, Barbara Vidal, MSc, Birgit M. Reipert, PhD, Katharina Nora Steinitz, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2014) 124 (21): 1489.

https://doi.org/10.1182/blood.V124.21.1489.1489

Published: 2014

Journal Articles

Clearance and Genetic Variability of Von Willebrand Factor Are Major Determinants of the Pharmacokinetic Behavior of Factor VIII Concentrates in the Treatment of Pediatric Hemophilia A

Kenichi Ogiwara, MD PhD, Laura L Swystun, PhD, Ilinca Georgescu, Christine Brown, Angie Tuttle, Shawn Tinlin, Jayne Leggo, Silvia Albánez, MSc, Manuel Carcao, MD MSc, Victor S. Blanchette, MD FRCPC, Christoph Male, MD MSC, Katharina Thom, David Lillicrap, MD

Blood (2014) 124 (21): 473.

https://doi.org/10.1182/blood.V124.21.473.473

Published: 2014

Journal Articles

Age-Related Increases in Plasma Factor VIII and Von Willebrand Factor in a C57BL/6 Mouse Model Are Associated with Increased Factor VIII and Von Willebrand Factor Gene Expression and Reduced Expression of the Clearance Receptor, Stabilin-2

Silvia Albánez, MSc, Alison Michels, BSc, Kate Sponagle, David Lillicrap, MD

Blood (2014) 124 (21): 4228.

https://doi.org/10.1182/blood.V124.21.4228.4228

Published: 2014

Journal Articles

Characterization of Type 2N Von Willebrand Disease Mutations Using Ιn Vitro and Ιn Vivo Mouse Models

Laura L Swystun, PhD, Ilinca Georgescu, Meghan Deforest, Mia Golder, PhD, Kate Sponagle, Christine Brown, Colleen Notley, David Lillicrap, MD

Blood (2014) 124 (21): 471.

https://doi.org/10.1182/blood.V124.21.471.471

Published: 2014

Journal Articles

Administration of Dexamethasone during Initial Exposure to Factor VIII Prevents the Development of Anti-Factor VIII Antibodies and Increases the Proportion of Thymic but Not Splenic Regulatory T Cells in the Exon 16 Knockout C57Bl6 Hemophilia Α Mouse Model

Maria T. Georgescu, BScH, Paul C. Moorehead, MDMS, MSc, Kate Sponagle, Birgit M. Reipert, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2014) 124 (21): 237.

https://doi.org/10.1182/blood.V124.21.237.237

Published: 2014

Journal Articles

The Endothelial Lectin Receptor CLEC4M Internalizes Factor VIII and Von Willebrand Factor Via a Clathrin-Coated Pit-Dependent Mechanism

Laura L. Swystun, PhD, Colleen Notley, Ilinca Georgescu, Paula D. James, MD, David Lillicrap, MD

Blood (2013) 122 (21): 1091.

https://doi.org/10.1182/blood.V122.21.1091.1091

Published: 2013

Journal Articles

Genetic Variability of the CLEC4M Endothelial Lectin Receptor Modulates Binding and Internalization of Von Willebrand Factor and Contributes to Variance in Plasma VWF Levels

Laura L. Swystun, PhD, Natalia Rydz, MD, Colleen Notley, Jonathan J. Riches, Andrew D Paterson, MD, Robert R. Montgomery, MD, Paula D. James, MD, David Lillicrap, MD

Blood (2012) 120 (21): 16.

https://doi.org/10.1182/blood.V120.21.16.16

Published: 2012

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A Practical, One Clinic Visit, Population Pharmacokinetic (PK) Protocol for Generation of PK Profiles in Subjects with Severe Hemophilia a

The Highly Prevalent Deletions in F8 Intron 13 Found in French Mild Haemophilia a Patients Result of Both Founder Effect and Recurrent De Novo Events

Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease

Immune Tolerance Induction in Hemophilia A Patients Using Wilate® —a Canadian 10 Year Study (PREVAIL)

Does Age Affect Desmopressin Responsiveness in Patients with Von Willebrand Disease?

A Novel Von Willebrand Factor Fragment Acts As a Chaperone to Prolong the Half-Life of Recombinant Human FVIII (Simoctocog Alfa) in Hemophilia a Dogs and FVIII/VWF Double Knockout Mice

A Factor VIII Fusion with an Inactivated FIX Generates a Biologically Active Molecule with Delayed Clearance in a FVIII/VWF Knockout Mouse Model

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

Differential Glycosylation Between Recombinant Factor VIII Produced in Baby Hamster Kidney and Chinese Hamster Ovary Cells Confers Differences in Immunogenicity in a Humanized Hemophilia Α Mouse Model

Development of an Optimized rAAV2/6 Human Factor 8 cDNA Vector Cassette for Hemophilia a Gene Therapy

VWF-FVIII Interactions Influence Hemostatic Thrombus Stability in Murine Models of Hemophilia Α and Type 2N VWD

Histones Induce Endothelial Von Willebrand Factor Release and Subsequent Platelet Capture in In Vitro and In Vivo Models

Immunization Against Influenza but Not MMR Modulates the Anti-Factor VIII Immune Response in Hemophilia Α Mice

Administration of Dexamethasone during Initial Exposure to Factor VIII Induces Durable and Antigen-Specific Tolerance to Factor VIII in Hemophilia Α Mice with a Humanized Major Histocompatibility Complex II Transgene

Clearance and Genetic Variability of Von Willebrand Factor Are Major Determinants of the Pharmacokinetic Behavior of Factor VIII Concentrates in the Treatment of Pediatric Hemophilia A

Age-Related Increases in Plasma Factor VIII and Von Willebrand Factor in a C57BL/6 Mouse Model Are Associated with Increased Factor VIII and Von Willebrand Factor Gene Expression and Reduced Expression of the Clearance Receptor, Stabilin-2

Characterization of Type 2N Von Willebrand Disease Mutations Using Ιn Vitro and Ιn Vivo Mouse Models

Administration of Dexamethasone during Initial Exposure to Factor VIII Prevents the Development of Anti-Factor VIII Antibodies and Increases the Proportion of Thymic but Not Splenic Regulatory T Cells in the Exon 16 Knockout C57Bl6 Hemophilia Α Mouse Model

The Endothelial Lectin Receptor CLEC4M Internalizes Factor VIII and Von Willebrand Factor Via a Clathrin-Coated Pit-Dependent Mechanism

Genetic Variability of the CLEC4M Endothelial Lectin Receptor Modulates Binding and Internalization of Von Willebrand Factor and Contributes to Variance in Plasma VWF Levels

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