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Journal Articles

HSP90 Stabilizes B-Cell Receptor Kinases in a Multi-Client Interactome: PU-H71 Induces CLL Apoptosis in a Cytoprotective Microenvironment

Free
Yue Lynn Wang, MD PhD, Pin Lu, PhD, Jimmy Lee, MD, Chao Jie Zhen, BS, Gabriela Chiosis, PhD, Ailin Guo, Ph DMD
Journal: Blood
Blood (2016) 128 (22): 5105.
https://doi.org/10.1182/blood.V128.22.5105.5105
Published: 2016
Journal Articles

Dual SYK/JAK Inhibition Overcomes Ibrutinib Resistance in Chronic Lymphocytic Leukemia

Free
Yue Lynn Wang, MD PhD, Pin Lu, PhD, Greg P Coffey, PhD, Anjali Pandey, PhD, Ailin Guo, PhD MD
Journal: Blood
Blood (2016) 128 (22): 5377.
https://doi.org/10.1182/blood.V128.22.5377.5377
Published: 2016
Journal Articles

Clonal Evolution Pattern of Leukemia Progression and Richter Transformation in Ibrutinib-Relapsed CLL Patients

Free
Sabah Kadri, PhD, Jimmy Lee, MD, Carrie Fitzpatrick, PhD DABMG, Natalie Galanina, MD, Madina Sukhanova, PhD, Girish Venkataraman, MD MBBS, Shruti Sharma, PhD, Bradley Long, Megan Theissen, Mei Ming, PhD, Yuri Kobzev, Kang Wenjun, Ailin Guo, PhD MD, Weige V Wang, MD, Nifang Niu, PhD, Howie Lawrence Weiner, Michael J. Thirman, MD, Sonali M. Smith, MD, Jeremy P. Segal, MD PhD, Pin Lu, PhD, Y. Lynn Wang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3961.
https://doi.org/10.1182/blood.V128.22.3961.3961
Published: 2016
Journal Articles

An HSP90 Inhibitor, PU-H71, Antagonizes Stroma-Induced Pro-Survival Effects in CLL through Its Inhibition of Multi-Component B-Cell Receptor Signaling Pathway

Free
Ailin Guo, PhDMD, Pin Lu, PhD, Chaojie Zhen, PhD, Gabriela Chiosis, PhD, Yue Lynn Wang, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5289.
https://doi.org/10.1182/blood.V126.23.5289.5289
Published: 2015
Journal Articles

Higher BTK-Dependent Cell Proliferation in Unmutated Chronic Lymphocytic Leukemia Confers Increased Sensitivity to Ibrutinib

Free
Ailin Guo, PhDMD, Pin Lu, PhD, Natalie Galanina, MD, Chadi Nabhan, MD, Sonali M. Smith, MD, Morton Coleman, MD, Yue Lynn Wang, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5296.
https://doi.org/10.1182/blood.V126.23.5296.5296
Published: 2015
Journal Articles

SYK and STAT3 Are Active in Diffuse Large B-Cell Lymphoma: Activity of Cerdulatinib, a Dual SYK/JAK Inhibitor

Free
Y. Lynn Wang, MD PhD, Jiao Ma, PhD, Wei Xing, PhD, Pin Lu, MD PhD, Karen Dresser, Ailin Guo, PhDMD, Anjali Pandey, PhD, Pamela B. Conley, PhD, Hongbo Yu, MD PhD, Greg Coffey, PhD
Journal: Blood
Blood (2014) 124 (21): 926.
https://doi.org/10.1182/blood.V124.21.926.926
Published: 2014
Journal Articles

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL

Free
Richard R. Furman, MD, Shuhua Cheng, PhD, Pin Lu, MD, PhD, Menu Setty, Alexandar Perez, Ailin Guo, MD, PhD, Joelle Racchumi, BS, Jiao Ma, PhD, Morton Coleman, MD, Kabaleeswaran Venkataraman, PhD, Guozhou Xu, PhD, Wei Chen, PhD, Hao Wu, PhD, Betty Y. Chang, PhD, Christina Leslie, PhD, Y. Lynn Wang, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4914.
https://doi.org/10.1182/blood.V122.21.4914.4914
Published: 2013
Journal Articles

Dual SYK/JAK Inhibition Has a Broader Anti-Tumor Activity In Both ABC and GCB Types Of Diffuse Large B Cell Lymphoma

Free
Jiao Ma, PhD, Greg Coffey, PhD, Pin Lu, MD, PhD, Shuhua Cheng, PhD, Ailin Guo, MD, PhD, Anjali Pandey, PhD, Y. Lynn Wang, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1833.
https://doi.org/10.1182/blood.V122.21.1833.1833
Published: 2013
Journal Articles

BTK Inhibition Targets in Vivo CLL Proliferation Through Its Effects On B-Cell Receptor Signaling Activity.

Free
Y. Lynn Wang, MD, PhD, Shuhua Cheng, PhD, Jiao Ma, PhD, Ailin Guo, MD, PhD, Pin Lu, MD, PhD, John P. Leonard, MD, Morton Coleman, MD, Momo Liu, BS, Joseph J. Buggy, PhD, Richard R. Furman, MD
Journal: Blood
Blood (2012) 120 (21): 2903.
https://doi.org/10.1182/blood.V120.21.2903.2903
Published: 2012