Figure 2.
Primary KIR3DL1+NK cells are educated by HLA-A*24 and HLA-A*32, but not HLA-A*23 and HLA-A*25. PBMCs from healthy individuals with HLA-A*24, HLA-A*32, HLA-A*23, or HLA-A*25 and lacking HLA-B Bw4+ alleles were cultured with K562 cells for 5 hours and evaluated for degranulation and cytokine response. CD107a expression (A) and intracellular IFN-γ (B) were evaluated on single positive KIR3DL1 NK cells (KIR3DL1sp). Donor NK cells were stratified according to KIR3DL1high (H) or KIR3DL1low (L) expression. The mean and standard deviation are shown with *P < .05 using unpaired Mann-Whitney U test.

Primary KIR3DL1+NK cells are educated by HLA-A*24 and HLA-A*32, but not HLA-A*23 and HLA-A*25. PBMCs from healthy individuals with HLA-A*24, HLA-A*32, HLA-A*23, or HLA-A*25 and lacking HLA-B Bw4+ alleles were cultured with K562 cells for 5 hours and evaluated for degranulation and cytokine response. CD107a expression (A) and intracellular IFN-γ (B) were evaluated on single positive KIR3DL1 NK cells (KIR3DL1sp). Donor NK cells were stratified according to KIR3DL1high (H) or KIR3DL1low (L) expression. The mean and standard deviation are shown with *P < .05 using unpaired Mann-Whitney U test.

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