Figure 1.
Interindividual variability of busulfan exposure. Each symbol denotes the cAUC (mg/L × h) in relation to the administered total cumulative dose (mg/kg bw) of busulfan in patients aged <1 year (squares), >1 year and <4 years (circles), and >4 years (triangles) of age. Filled symbols denote patients developing SOS. The target submyeloablative cAUC (45-65 mg/L × h) is depicted in gray.

Interindividual variability of busulfan exposure. Each symbol denotes the cAUC (mg/L × h) in relation to the administered total cumulative dose (mg/kg bw) of busulfan in patients aged <1 year (squares), >1 year and <4 years (circles), and >4 years (triangles) of age. Filled symbols denote patients developing SOS. The target submyeloablative cAUC (45-65 mg/L × h) is depicted in gray.

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