Kaplan-Meier curve for OS from the time of diagnosis in 592 patients based on BU staging system. Thresholds used: BNP higher than 81 pg/mL and TnI higher than 0.1 ng/mL with staging system as follows: no thresholds reached, stage I; 1 threshold reached, stage II; 2 thresholds reached, stage III; BNP higher than 700 pg/mL and stage III, stage IIIb. Number at risk for each stage at each point is shown below the x-axis. Stage I did not reach median survival through 12 years of follow-up. Stage II median survival was 9.4 years. Stage III median survival was 4.3 years. Stage IIIb median survival was 1.0 year.