Clonal contributions to various hematopoietic cell types. (A) The number of highly active HSPC clones for each patient at last follow-up (unique ISs with at least 6 cells in 1 of the 5 cell types). (B) Contribution of highly active clones to total hematopoiesis output. The proportion of the total cell count (from all cell types) in the whole IS dataset accounted for by highly active clones is shown. (C-D) Lineage bias analysis for different combinations of cell lineage abundance and in each patient, represented as a bias histogram. For each IS, the ratio of abundance is calculated for the 2 cell types and then classified as balanced (Bal.) through a >10-fold difference. (C) Lineage bias for granulocytes vs monocytes (G vs M). (D) Lineage bias for granulocytes vs T cells (G vs T).