Figure 7.
Figure 7. Adenovirus-mediated IκBΔN expression abrogates NF-κB activity and induces massive spontaneous apoptosis in HDLM2 cells. / (A) Whole cell extracts of HDLM2 cells infected with Ad5 control or Ad5-IκBΔN were analyzed by EMSA using an H2K binding site probe; (B) growth rates of uninfected or infected HDLM2 cells, as indicated, were determined in 5 independent experiments; and (C) apoptotic cells were determined by annexin V staining in uninfected or infected cells. / Abbreviations: N, novel NF-κB target genes. / Reprinted with permission from Hinz M, Lemke P, Anagnostopoulos I, et al. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin’s disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med. 2002;196:605–617. by copyright permission of The Rockefeller University Press.

Adenovirus-mediated IκBΔN expression abrogates NF-κB activity and induces massive spontaneous apoptosis in HDLM2 cells.

(A) Whole cell extracts of HDLM2 cells infected with Ad5 control or Ad5-IκBΔN were analyzed by EMSA using an H2K binding site probe; (B) growth rates of uninfected or infected HDLM2 cells, as indicated, were determined in 5 independent experiments; and (C) apoptotic cells were determined by annexin V staining in uninfected or infected cells.

Abbreviations: N, novel NF-κB target genes

Reprinted with permission from

Hinz M, Lemke P, Anagnostopoulos I, et al. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin’s disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med. 2002;196:605–617.
by copyright permission of The Rockefeller University Press.

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