D’Andrea Figure 1 (in D’Andrea et al). Schematic representation of the Fanconi anemia (FA) pathway. / DNA damage-inducible or S phase–specific monoubiquitination of FANCD2 requires the FA protein complex (A,C,G,E,F complex). Loss of any one of these five FA protein subunits results in instability and degradation of the other subunits. Monoubiquitination targets D2 to DNA repair foci containing BRCA1, BRCA2, and RAD51. The BRCA2 protein may function upstream in this pathway by promoting D2 monoubiquitination and/or downstream in the pathway by promoting homologous recombination repair. The interaction of BRCA2/FANCD1 with the RAD51 protein strongly supports a role of this pathway in the regulation of DNA repair activity. Disruption of this pathway leads to chromosome breakage, pancytopenia, and cancer predisposition.

D’Andrea Figure 1 (in D’Andrea et al). Schematic representation of the Fanconi anemia (FA) pathway.

DNA damage-inducible or S phase–specific monoubiquitination of FANCD2 requires the FA protein complex (A,C,G,E,F complex). Loss of any one of these five FA protein subunits results in instability and degradation of the other subunits. Monoubiquitination targets D2 to DNA repair foci containing BRCA1, BRCA2, and RAD51. The BRCA2 protein may function upstream in this pathway by promoting D2 monoubiquitination and/or downstream in the pathway by promoting homologous recombination repair. The interaction of BRCA2/FANCD1 with the RAD51 protein strongly supports a role of this pathway in the regulation of DNA repair activity. Disruption of this pathway leads to chromosome breakage, pancytopenia, and cancer predisposition.

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