Guidelines for the management of PNH.

This algorithm⁴⁰  is based on the consideration that patients with this condition vary considerably (a) in terms of clinical severity, and (b) in terms of the contributions of the PNH clone and of bone marrow failure (BMF) respectively to determining the overall clinical picture. Some patients have been cured by bone marrow transplantation (BMT); at the other end of the spectrum, some of the patients who for a long time have been `living with PNH'—by choice or otherwise—have eventually experienced spontaneous recovery.⁴