Lipoprotein distribution. Blood was drawn from (A) ApoE^–/–LDLR^–/–LRP^– (•) and ApoE^–/–LDLR^–/– (○) mice and from (B) huAPOCI transgenic (▵) and nontransgenic control (▴) mice. Lipoproteins were size fractionated by FPLC. Individual fractions were analyzed for cholesterol.