Figure 6. Multiple destinies of incoming... | American Society of Hematology

Figure 6.

$Figure 6. Multiple destinies of incoming HIV-1 particles in DCs. Virions are bound and internalized by DCs through various (DC-SIGN–dependent and –independent) pathways. After capture, the life span of HIV-1 is rather short, and most of the incoming virions will be degraded in an acidic compartment (probably lysosomes). This may lead to MHC-II antigen presentation. Some viral particles escape lysosomal degradation. A fraction will be transmitted to permissive CD4+ lymphocytes, probably by recycling to the cell surface, whereas another part will gain access to the cytoplasm. Cytosolic viral material may be the source of low levels of productive infection of DCs. The proteasome will also degrade cytosolic viral proteins, leading to MHC-I antigen presentation.$

Multiple destinies of incoming HIV-1 particles in DCs. Virions are bound and internalized by DCs through various (DC-SIGN–dependent and –independent) pathways. After capture, the life span of HIV-1 is rather short, and most of the incoming virions will be degraded in an acidic compartment (probably lysosomes). This may lead to MHC-II antigen presentation. Some viral particles escape lysosomal degradation. A fraction will be transmitted to permissive CD4⁺ lymphocytes, probably by recycling to the cell surface, whereas another part will gain access to the cytoplasm. Cytosolic viral material may be the source of low levels of productive infection of DCs. The proteasome will also degrade cytosolic viral proteins, leading to MHC-I antigen presentation.

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