Effect of varying concentrations of convulxin on platelet shape change and aggregation.

Aspirin-treated human platelets were washed and resuspended in Hepes-buffered Tyrode solution. Platelet response was measured in the presence of extracellular fibrinogen (1 mg/mL) and was performed in a cuvette maintained at 37°C with stirring. The ordinate represents the observed changes in light absorbance (optical density) due to light scattering by the platelets. These tracings are representative of results observed on 3 separate occasions from 3 different donors.