Fig. 3.
Fig. 3. Ig/TCR gene rearrangement stability in 5 precursor-B–ALL patients subjected to comparative heteroduplex PCR analysis at diagnosis and at presumably secondary AML. / All Ig/TCR gene rearrangements identified at diagnosis in patients 3797, 4522, 5407, and 5985 were lost, which is in line with secondary AML. In contrast, several IGH and IGK gene rearrangements in patient 3991 were preserved, suggesting a phenotypic shift from ALL to AML. Black squares represent monoclonal rearrangements; gray squares, biclonal/oligoclonal rearrangements; white squares, oligoclonal/polyclonal rearrangements. All squares above the line represent stable MRD-PCR targets, while all squares below the line represent Ig/TCR gene rearrangements lost owing to clonal evolution. VH indicates VH-JH gene rearrangements; DH, DH-JH gene rearrangements;Vκ, Vκ-Jκ gene rearrangements; Vγ, Vγ-Jγ gene rearrangements; Jδ, rearrangements to Jδ1-Dδ3 region detected by Southern blot analysis.

Ig/TCR gene rearrangement stability in 5 precursor-B–ALL patients subjected to comparative heteroduplex PCR analysis at diagnosis and at presumably secondary AML.

All Ig/TCR gene rearrangements identified at diagnosis in patients 3797, 4522, 5407, and 5985 were lost, which is in line with secondary AML. In contrast, several IGH and IGK gene rearrangements in patient 3991 were preserved, suggesting a phenotypic shift from ALL to AML. Black squares represent monoclonal rearrangements; gray squares, biclonal/oligoclonal rearrangements; white squares, oligoclonal/polyclonal rearrangements. All squares above the line represent stable MRD-PCR targets, while all squares below the line represent Ig/TCR gene rearrangements lost owing to clonal evolution. VH indicates VH-JH gene rearrangements; DH, DH-JH gene rearrangements;Vκ, Vκ-Jκ gene rearrangements; Vγ, Vγ-Jγ gene rearrangements; Jδ, rearrangements to Jδ1-Dδ3 region detected by Southern blot analysis.

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