Representative histologic appearance of glomeruli in mice injected with L8D or 6-19J cells and glomerular IgG deposits in mice injected with purified L8D or 6-19J IgG3 mAb.

Mice injected with L8D cells (A) developed severe glomerular lesions characterized by the massive deposition of PAS-positive materials along the glomerular capillary walls, corresponding to the “wire-loop” lesions, with some proliferative and exudative changes, whereas no significant glomerular changes were seen in 6-19J–injected mice (B) (PAS; magnification, 200×). Note substantial glomerular deposits of IgG 24 hours after intraperitoneal injection of 10 mg L8D mAb (C), which markedly contrast with the lack of deposits in mice injected with the same dose of 6-19J mAb (D) (magnification, 200 ×).