Fig. 6.
Fig. 6. fVIII-Specific IgG1 is increased after blocking CD40-CD40L interaction in nontolerant mice. / Two mice were injected 3 times each with fVIII alone (A,B) or treated with anti-CD40L plus fVIII (C,D). Ten days after each treatment, blood was drawn, and anti-fVIII IgG1 (black bar) and anti-fVIII IgG2a (white bar) titers were determined by ELISA. Mice were challenged with fVIII alone (0.2 μg) 3 times after treatment, and plasma samples were tested for anti-fVIII IgG1 and IgG2a. Results are expressed by end-point titration.

fVIII-Specific IgG1 is increased after blocking CD40-CD40L interaction in nontolerant mice.

Two mice were injected 3 times each with fVIII alone (A,B) or treated with anti-CD40L plus fVIII (C,D). Ten days after each treatment, blood was drawn, and anti-fVIII IgG1 (black bar) and anti-fVIII IgG2a (white bar) titers were determined by ELISA. Mice were challenged with fVIII alone (0.2 μg) 3 times after treatment, and plasma samples were tested for anti-fVIII IgG1 and IgG2a. Results are expressed by end-point titration.

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