Fig. 5.
![Fig. 5. CRP elevates Ca++ in XID megakaryocytes. / Single megakaryocytes from control and XID mice were microinjected with Fura-2, pretreated or not for 15 minutes with wortmannin (wort) (100 nM), and stimulated by CRP (4 μg/mL). Intracellular Ca++was determined as described in “Materials and methods.” The increase in [Ca++]i in response to CRP is shown as histogram showing the mean ± SE. Results are from 8 to 10 cells from a minimum of 4 different mice. *corresponds to results significantly different from basal.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/3/10.1182_blood.v97.3.678/6/h80310652005.jpeg?Expires=1751003088&Signature=I-mMKOmXhQ5mluHVcRVpjSG9p~l6UNc2IKIhFiU5IS7FCmWc8xsUvHxvvblTCyqOUq4Qo65GvxnaAdK5YJz~hfzPDkCbmGq6E04l0KwUhSPPFJkEB64E0zfb5YbN4Pnp3W6dTEbl051UV2jAkvY7XAIvmVXYtg-GPgwDQoiocRtSTzs5uslbpU6uTV-h7tRLjeBwfHmNsJP0vGk3CBSWaegkRjaTJ539zilg8ttwiS8kDNjJwhe75TDhOyulp7LCbVbKlQwhlop~SMqFW8PRAS8SkHUL5uDhSCjJSpsGDmHNW60~y6~txpNaFIS56yWwyRk~A~Itzm9EywA~x~uv1A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CRP elevates Ca++ in XID megakaryocytes.
Single megakaryocytes from control and XID mice were microinjected with Fura-2, pretreated or not for 15 minutes with wortmannin (wort) (100 nM), and stimulated by CRP (4 μg/mL). Intracellular Ca++was determined as described in “Materials and methods.” The increase in [Ca++]i in response to CRP is shown as histogram showing the mean ± SE. Results are from 8 to 10 cells from a minimum of 4 different mice. *corresponds to results significantly different from basal.
