Dose-dependent effects of KF58333 on induction of apoptosis.

K562 cells were cultured with increasing concentration of KF58333 for 48 hours and analyzed as described in “Materials and methods.” The number of annexin V–positive/PI-negative cells is indicated in the lower right quadrant. Quad, quadrant; UL, upper left; UR, upper right; LL, lower left; LR, lower right.