Differentiation and growth of K562 cells.

The relationship between differentiation and growth of K562 cells and treatment with HA (A), radicicol (B), KF25706 (C), and KF58333 (D). K562 cells were cultured with increasing concentrations of HA, radicicol, KF25706, and KF58333 for 72 hours and analyzed for differentiation and cell growth as described in “Materials and methods.” Percent of GPA-positive cells and relative percent of growth compared with untreated cells are plotted.