Fig. 3.
Clonal evolution identified by FRA3/JH PCR at various stages of disease in patient 48. Lane 1, DNA size marker; lane 2, four clones identified at presentation; lane 3, two major clones together with 2 minor subclones identified at week 2; lane 4, two clones identified at relapse; lane 5, a smear of PCR products in control sample from normal bone marrow.